Reference

Purification of bile acids for medical use

Purification of bile acids for medical use. (Tokyo Tanabe Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58113202 A2 6 Jul 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C08B037-00. APPLICATION: JP 81-209605 28 Dec 1981. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Crude chenodeoxycholic acid (I) [474-25-9], ursodeoxycholic acid [128-13-2] and 3a-hydroxy-7-ketocholanic acid [28332-54-9] for medical use are purified by fractionation with org. solvents (sec-Bu alc. [78-92-2], tert-amyl alc. [75-85-4], n-hexyl alc. [111-27-3], 2-ethylhexyl alc. [104-76-7] and n-octyl alc. [111-87-5]). As an example, 300 g I (94% pure) was dissolved in n-hexyl alc. (3 L), treated with 3.12 g NaOH in 6.In this article, certain chemicals are used. Some of their cas registry numbers are 111-87-5 and 75-85-4 2 L H2O and the mixt. was stirred at room temp. for 5 min. The upper layer was treated with 1.56 g NaOH in 6.2 L H2O, the mixt. was stirred for 5 min and the org. phase was sepd., washed with water and treated with 31.2 g NaOH in 6.2 L H2O while stirring. The bottom layer then was sepd., concd. and treated with 0.1N H2SO4 to form a ppt., which was crystd. with EtOAc to give cryst. I with 99.9% purity. A 85% yield was obtained. .

Direct gas chromatographic determination of alcohols and methyl tert-butyl ether in gasolines using infrared detection

Direct gas chromatographic determination of alcohols and methyl tert-butyl ether in gasolines using infrared detection. Cochrane, R. A.; Hillman, D. E. (Mater. Qual. Assur. Dir., Woolwich SE18 6TD, UK). J. Chromatogr., 287(1), 197-201 (English) 1984. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Section cross-reference(s): 80 The presence of alcs. and Me tert-Bu ether (I) [1634-04-4] in gasolines can be rapidly detd. by gas chromatog. sepn. on a mixed Porapak Q-Porapak N column with an IR detector. Suitable monitoring IR wavelengths are 9.25 mm for iso-PrOH [67-63-0] and MeOH [67-56-1], and 8.3 mm for I. 67-56-1 and 1634-04-4 which are cas registry numbers of substances are two of reagents here. Monitoring of mixts. of sec-BuOH [78-92-2] with MeOH or I by a single wavelength is difficult due to overlap. Sample pretreatment was limited to diln. with alc.-free gasoline. .