Detail of "89-01-0"

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CAS Number:
89-01-0
Name:
2,3-Pyrazinedicarboxylicacid
Superlist Name:
2,3-Pyrazinedicarboxylic acid
Molecular Structure:
Formula:
C₆H₄N₂O₄
Molecular Weight:
168.107
Synonyms:
2,3-Dicarboxypyrazine;NSC 1908;
EINECS:
201-875-3
Density:
1.665 g/cm³
Melting Point:
185-188 °C
Boiling Point:
449.1 °C at 760 mmHg
Flash Point:
225.4 °C
Solubility:
soluble in water
Appearance:
white to pale brown crystalline powder
Hazard Symbols:
F, C
Risk Codes:
36/37/38
Safety:
22-24/25-45-36/37/39-26-16 Details

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Reference

The excitotoxicity of heterocyclic dicarboxylic acids in rat hippocampal slices: structure-activity relationships: The excitotoxicity of heterocyclic dicarboxylic acids in rat hippocampal slices: structure-activity relationships. Schurr, Avital; West, C. A.; Rigor, B. M. (Sch. Med., Univ. Louisville, Louisville, KY 40292, USA). Brain Res.There are some reagents with their cas registry numbers 89-00-9 and 89-01-0 are used in this study., 571(1), 145-8 (English) 1992. CODEN: BRREAP. ISSN: 0006-8993. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 14 The structural resemblance of certain heterocyclic dicarboxylates to aspartate and glutamate led investigators to study their potency as agonists and antagonists of the N-methyl-D-aspartate (NMDA) receptor. The sensitivity of hypoxic rat hippocampal slices to NMDA ligands is several fold greater than that of normoxic slices. In the present study, the excitotoxic potency of heterocyclic dicarboxylates was assessed electrophysiol. by measuring their ability to enhance hypoxic and hypoglycemic neuronal damage in the rat hippocampal slice prepn. Four compds. were tested: quinolinate (QUIN), 4,5-imidazole-dicarboxylate (IZDA), 1,2,3-triazole-4,5-dicarboxylate (TZDA), and 2,3-pyrazinedicarboxylate (PZDA). QUIN was the most toxic drug in enhancing both hypoxic and hypoglycemic neuronal damage. IZDA and TZDA were slightly less toxic than QUIN, while PZDA was innocuous. The effect of the 3 active drugs was blocked by the NMDA competitive antagonist DL-2-amino-5-phosphonovalerate. The sequence -N-CH(COOH)-CH(COOH)- appears to be a prerequisite for a heterocyclic dicarboxylate to exert NMDA-type agonistic properties. A 5-membered ring heterocyclic compd. which contains more than one nitrogen atom in its ring retains its NMDA-type toxicity while a 6-membered ring with more than one nitrogen atom (PZDA) does not. .

Pyrazine-2,3-dicarboxyic acid: Pyrazine-2,3-dicarboxyic acid. Hoffman, Boguslaw; Zmojdzin, Andrzej (Chemiczna Spoldzielnia Pracy "Synteza", Pol.Several substances are used for example 89-01-0 and 91-19-0 which are their cas registry numbers.). Pol. PL 81899 31 May 1976, 3 pp. (Polish). (Poland). CODEN: POXXA7. CLASS: IC: C07D241-74. APPLICATION: PL 71-145948 2 Feb 1971. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Pyrazine-2,3-dicarboxylic acid (I) was obtained by oxidn. of quinoxaline (II). Thus, a soln. of 20 g II in 50 ml H2O was treated with 400 ml of a NaClO soln. contg. 14.5% active Cl, 100 ml 20% NaOH, and 200 ml 7.5% KMnO4 at 60.degree. until decolorization occurred to give 66% I. .

Detail of "89-01-0"

2,3-Pyrazinedicarboxylicacid

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Reference