Reference

Oxidative and conjugative metabolism of xenobiotics by isolated rat and hamster acinar cells

Oxidative and conjugative metabolism of xenobiotics by isolated rat and hamster acinar cells. Wiebkin, Philip; Schaeffer, Barbara K.; Longnecker, Daniel S.; Curphey, Thomas J. (Dep. Pathol., Dartmouth Med. Sch., Hanover, NH 03756, USA). Drug Metab. Dispos., 12(4), 427-31 (English) 1984. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Rat and hamster pancreas acinar cells isolated from 5,6-benzoflavone-pretreated animals carried out the cytochrome P 450-dependent O-deethylation of 7-ethoxycoumarin [31005-02-4], 2-,3-, and 4-hydroxylation of biphenyl [92-52-4], and 3-hydroxylation of benzo[a]pyrene [50-32-8] at measurable rates. These rates were lower (16-210-fold in the rat and 290-2670-fold in the hamster) than those in incubations using hepatocytes isolated from 5,6-benzoflavone-pretreated animals. Hydroxylation of biphenyl at the 2-, 3-, and 4-positions proceeded at similar rates in rat acinar cells. The rate of 3-hydroxybiphenyl [580-51-8] formation was barely detectable in hamster acinar cells where the rates of 2-hydroxybiphenyl (I) [90-43-7] and 4-hydroxybiphenyl [92-69-3] formation were slower than in the rat. The deethylation product of 7-ethoxycoumarin, 7-hydroxycoumarin [93-35-6], was conjugated with sulfate and glucuronic acid moieties at appreciable rates by acinar cells isolated from rat and hamster.

Polyolefin polymerization and catalyst

Polyolefin polymerization and catalyst. Hawley, Gil Ross; Masino, Albert Peter (Phillips Petroleum Co. , USA). Eur. Pat. Appl. EP 115833 A1 15 Aug 1984, 17 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C08F010-00; C08F004-64; C08F036-04. APPLICATION: EP 84-100871 27 Jan 1984. PRIORITY: US 83-461801 28 Jan 1983. DOCUMENT TYPE: Patent CA Section: 35 (Chemistry of Synthetic High Polymers) A Mg dihalide is combined with water and used with a benzoate ester, an alkoxy titanium compd., an organoaluminum halide, and a Ti halide in the prepn. of a catalyst for the polymn. of olefins, esp. for stereoregular polymn. of propene. The catalyst has higher activity than catalysts prepd. similarly but without the addn. of water to the Mg halide. Thus, 19.8 g anhyd. MgCl2 (contg. u1% water) in xylene was treated with 1.0 mol water/mol MgCl2, combined with 25.0 g 4-phenylphenol [92-69-3] and 35.8 g Ti(OBu)4 [5593-70-4], heated at 100°, treated with 7.5 mL BzOEt [93-89-0], heated at 100°, mixed at 25° with xylene, treated slowly with 125 mL 25% soln. of ethylaluminum sesquichloride [12075-68-2] in heptane to give a ppt. which was sepd., mixed (20 g) with a soln. comprising TiCl4 360, HSiCl3 270, and SiCl4 90 mL, and heated 1 h at 100°. The ppt. was sepd. and used with Et3Al [97-93-8], ethyl anisate [94-30-4], and Et2AlCl [96-10-6] for the polymn. of propene at 70° in the presence of H. The catalyst gave 22.9 kg polypropene [9003-07-0]/g catalyst/h, compared with 2.33 when water was not added to the MgCl2 used for catalyst prepn. The polymer contained 3.6% xylene-sol. material and 0.7% propene-sol. material.