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1,1,3,3-Tetramethyldisilazane

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Name

1,1,3,3-Tetramethyldisilazane

EINECS 240-072-2
CAS No. 15933-59-2 Density 0.752 g/mL at 25 °C(lit.)
PSA 12.03000 LogP 0.93370
Solubility N/A Melting Point 99-100 °C
Formula C4H15NSi2 Boiling Point 91.1 °C at 760 mmHg
Molecular Weight 133.341 Flash Point 17 °F
Transport Information N/A Appearance Clear colorless to faintly yellow liquid
Safety 16-26-36 Risk Codes 11-36/37/38
Molecular Structure Molecular Structure of 15933-59-2 (1,1,3,3-Tetramethyldisilazane) Hazard Symbols FlammableF; IrritantXi
Synonyms

Disilazane,1,1,3,3-tetramethyl- (6CI,7CI,8CI);1,1,3,3-Tetramethyldisilazane;1,3-Dihydrido-1,1,3,3-tetramethyldisilazane;Bis(dimethylsilyl)amine;LS 7050;NSC 139849;TMDS;Tetramethyldisilazane;

Article Data 11

1,1,3,3-Tetramethyldisilazane Synthetic route

1066-35-9

dimethylmonochlorosilane

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
With ammonia In hexane at -30 - 20℃; for 6h; Inert atmosphere; Schlenk technique;90%
With ammonia In hexane at -30 - 20℃; for 6h; Inert atmosphere; Schlenk technique;90%
With ammonia
With ammonia
With ammonia In pentane at -25 - 20℃; for 6h; Schlenk technique; Inert atmosphere;197 g

tetramethyldisilazane

99892-23-6

N,N',N''-trimethyl-1,4,7,10-tetraazacyclododecane

C15H39MgN5Si2

B

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
In pentane at 25℃; for 0.5h; Inert atmosphere; Schlenk technique; Glovebox;A 86%
B n/a
1066-35-9

dimethylmonochlorosilane

999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

A

75-77-4

chloro-trimethyl-silane

B

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride Heating;A n/a
B 70%

C22H30F12NO3S2Si2Y

67-63-0

isopropyl alcohol

A

C21H23F12O4S2Y

B

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
In dichloromethane-d2 Inert atmosphere;
67-51-6

3,5-dimethyl-1H-pyrazole

1414380-27-0

tris(tetramethyldisilazanido)bis(tetrahydrofuran)cerium

A

Ce(3,5-dimethylpyrazolato)3

B

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
In tetrahydrofuran-d8; benzene-d6 Inert atmosphere;
67-51-6

3,5-dimethyl-1H-pyrazole

tetramethyldisilazane

A

[Ce(Me2pz)4(Me2pzH)]

B

15933-59-2

1,1,3,3-tetramethyldisilazane

Conditions
ConditionsYield
In benzene-d6 at 20℃; Inert atmosphere;
15933-59-2

1,1,3,3-tetramethyldisilazane

108-95-2

phenol

18246-19-0

dimethylphenoxysilane

Conditions
ConditionsYield
100%
With dimethylmonochlorosilane; triethylamine for 1h; temp.: below 40 deg C;57%
With dimethylmonochlorosilane Heating;
at 20 - 160℃; for 2h; Inert atmosphere;
106-48-9

4-chloro-phenol

15933-59-2

1,1,3,3-tetramethyldisilazane

30342-25-7

(4-Chloro-phenoxy)-dimethyl-silane

Conditions
ConditionsYield
100%
at 20 - 160℃; for 2h; Inert atmosphere;
100-02-7

4-nitro-phenol

15933-59-2

1,1,3,3-tetramethyldisilazane

79516-20-4

Dimethyl-(4-nitro-phenoxy)-silane

Conditions
ConditionsYield
100%
at 20 - 160℃; for 2h; Inert atmosphere;
106-44-5

p-cresol

15933-59-2

1,1,3,3-tetramethyldisilazane

76058-60-1

Dimethyl-p-tolyloxy-silane

Conditions
ConditionsYield
100%
at 20 - 160℃; for 2h; Inert atmosphere;

1,1,3,3-Tetramethyldisilazane Specification

The 1,1,3,3-Tetramethyldisilazane, with the CAS registry number 15933-59-2 and EINECS registry number 240-072-2, has the systematic name of N-(dimethylsilyl)-1,1-dimethylsilanamine. It is a kind of clear colorless to faintly yellow liquid which is moisture Sensitive, and it belongs to the following product categories: Analytical Chemistry; Dimethylsilylation (GC Derivatizing Reagents); GC Derivatizing Reagents; Si (Classes of Silicon Compounds); Si-H Compounds; Silazanes; Silylation (GC Derivatizing Reagents); Si-N Compounds. The molecular formula of the chemical is C4H15NSi2.

The characteristics of 1,1,3,3-Tetramethyldisilazane as followings: (1)ACD/LogP: 3.49; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.41; (4)ACD/LogD (pH 7.4): 1.16; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1.25; (7)ACD/KOC (pH 5.5): 1.59; (8)ACD/KOC (pH 7.4): 8.93; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 3.24 Å2; (13)Enthalpy of Vaporization: 33.11 kJ/mol; (14)Boiling Point: 91.1 °C at 760 mmHg; (15)Vapour Pressure: 54.6 mmHg at 25°C.

Uses of 1,1,3,3-Tetramethyldisilazane: It can react with phenol to produce dimethylphenoxysilane. This reaction will need reagent triethylamine and dimethylchlorosilane. The reaction time is 1 hour with temperature below 40°C, and the yield is about 57%.

You should be cautious while dealing with this chemical. It is a kind of highly flammable chemical which irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Keep away from sources of ignition - No smoking; Wear suitable protective clothing; In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: N([SiH](C)C)[SiH](C)C
(2)InChI: InChI=1/C4H15NSi2/c1-6(2)5-7(3)4/h5-7H,1-4H3
(3)InChIKey: NQCZAYQXPJEPDS-UHFFFAOYAW

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