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1,2-Dimethyl-3-hydroxy-4-pyridone
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Name

1,2-Dimethyl-3-hydroxy-4-pyridone

 EINECS 212-783-8
CAS No. 30652-11-0 Density 1.225 g/cm3
PSA 42.23000 LogP 0.39930
Solubility soluble in hot water Melting Point 272-275 °C(lit.)
Formula C7H9NO2 Boiling Point 232.7 °C at 760 mmHg
Molecular Weight 139.154 Flash Point 94.5 °C
Transport Information N/A Appearance White needles
Safety 26-36-37/39 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 30652-11-0 (3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE) Hazard Symbols HarmfulXn
Synonyms

4(1H)-Pyridone,3-hydroxy-1,2-dimethyl- (8CI);1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone;1,2-Dimethyl-3-hydroxypyridin-4-one;1,2-Dimethyl-3-hydroxypyridine-4-one;3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone;3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;3-Hydroxy-1,2-dimethyl-4-pyridinone;3-Hydroxy-1,2-dimethyl-4-pyridone;APO 66;CGP 37391;CP 20 (chelatingagent);DN 18001AF;Deferiprone;Ferriprox;L 1 (chelatingagent);

Article Data 22

1,2-Dimethyl-3-hydroxy-4-pyridone Synthetic route

90037-22-2

1,2-dimethyl-3-(benzyloxy)-4(1H)-pyridinone

30652-11-0

deferiprone

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 2h;80%
With hydrogen; palladium on activated charcoal In tetrahydrofuran under ambient conditions;65%
With concentrated hydrobromic acid
118-71-8

Maltol

74-89-5

methylamine

30652-11-0

deferiprone

Conditions
ConditionsYield
In water for 10h; Reflux;69%
In water at 160 - 162℃; under 6750.5 Torr; for 0.0216667h; Irradiation;65%
In water for 6.5h; Heating;60%
3420-59-5

isomaltol

74-89-5

methylamine

30652-11-0

deferiprone

Conditions
ConditionsYield
In water for 20h; Heating;64%
82756-28-3

3-(β-D-galactopyranosyloxy)-2-furanyl methyl ketone

74-89-5

methylamine

30652-11-0

deferiprone

Conditions
ConditionsYield
In water for 20h; Heating;49%
118-71-8

Maltol

593-51-1

methylamine hydrochloride

30652-11-0

deferiprone

Conditions
ConditionsYield
With potassium hydroxide In water at 50℃;25%
30652-11-0

deferiprone

[(hydrotris(3,5-phenylmethylpyrazolyl)borato)CoCl]

[(hydrotris(3,5-phenylmethylpyrazolyl)borato)Co(3,4-HOPO)]

Conditions
ConditionsYield
With (C2H5)3N In methanol; dichloromethane (C2H5)3N added to a soln. of Co complex, a soln. of ligand in MeOH added, stirred at room temp. overnight under N2; evapd. (vac.), dissolved in C6H6, filtered, crystd. by diffusion of the soln. with pentane; elem. anal.;98%
30652-11-0

deferiprone

bismuth (III) nitrate pentahydrate

100-21-0

terephthalic acid

7732-18-5

water

68-12-2, 33513-42-7

N,N-dimethyl-formamide

[Bi2(1,4-benzenedicarboxylate)(deferiprone-H)4(H2O)2]·2DMF

Conditions
ConditionsYield
at 100℃; for 72h; Sealed tube; High pressure;98%
...Expand
30652-11-0

deferiprone

7732-18-5

water

150747-55-0

tantalum pentaethoxide

tris(1,2-dimethyl-3-hydroxy-4(1H)-pyridone)oxotantalum

Conditions
ConditionsYield
In methanol; water addn. of soln. of tantalum compd. in methanol to soln. of deferiprone inmethanol, stirring at room temp. overnight, addn. of water, stirring fo r 30 min; evapn. at 40°C, washing with warm CHCl3, filtration, drying in vac., elem. anal.;97%

dichloro(mesitylene)ruthenium(II) dimer

30652-11-0

deferiprone

176792-83-9

[RuCl(C7H8NO2)(C6H3(CH3)3)]

Conditions
ConditionsYield
With NaOCH3 In methanol; water byproducts: NaCl; (N2); reflux (3 h); solvent removal, dissoln. (CH2Cl2), filtration (Celite), evapn.; elem. anal.;93%
30652-11-0

deferiprone

333-27-7

methyl trifluoromethanesulfonate

Trifluoro-methanesulfonate3-hydroxy-4-methoxy-1,2-dimethyl-pyridinium;

Conditions
ConditionsYield
In chloroform for 3h; Heating;90%

1,2-Dimethyl-3-hydroxy-4-pyridone Chemical Properties

Chemical Name: 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
IUPAC NAME: 3-Hydroxy-1,2-dimethylpyridin-4-one
CAS No.: 30652-11-0
RTECS: UU7785940
Molecular Formula: C7H9NO2
Molecular Weight: 139.15 g/mol
Melting Point: 272-275 °C(lit.)
Density: 1.225 g/cm3 
Flash Point: 94.5 °C
Boiling Point: 232.7 °C at 760 mmHg
Following is the structure of 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):


Product Categories about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0) are API intermediates ; Chelating Agents, Ligands ; Chelating Agents & Ligands ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Building Blocks ; Heterocyclic Building Blocks ; Piperidones
The chemical synonymous of 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0) are L1 ; Dmhp ; Deferidone ; Deferipron ; Deferiprone ; Cp20 ; 3-Hydroxy-1,2-Dimethyl-4(1h)Pyridinone ; 3-Hydroxy-1,2-Dimethyl-4(1h)-Pyridone

1,2-Dimethyl-3-hydroxy-4-pyridone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH		 BioMetals. Vol. 10, Pg. 247, 1997.
mammal (species unspecified) LD50 unreported > 1gm/kg (1000mg/kg)   Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996.
mouse LD50 intraperitoneal 983mg/kg (983mg/kg)   Blood. Vol. 76, Pg. 2389, 1990.
rat LD50 intraperitoneal 600mg/kg (600mg/kg)   Drugs of the Future. Vol. 13, Pg. 413, 1988.
rat LD50 oral 2gm/kg (2000mg/kg) CARDIAC: OTHER CHANGES Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996.
 

1,2-Dimethyl-3-hydroxy-4-pyridone Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes:
Xn: Harmful
Risk Statements about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):
R22 Harmful if swallowed. 
R36/37/38 Irritating to eyes, respiratory system and skin. 
Safety Statements about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39 Wear suitable gloves and eye/face protection.
Attentions:
1. Storage: Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.

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