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Name	1-PIPERONYLPIPERAZINE	EINECS	250-968-5
CAS No.	32231-06-4	Density	1.203 g/cm³
PSA	33.73000	LogP	1.08720
Solubility	Slightly soluble in water	Melting Point	36-40 °C(lit.)
Formula	C₁₂H₁₆N₂O₂	Boiling Point	330.5 °C at 760 mmHg
Molecular Weight	220.271	Flash Point	158.4 °C
Transport Information	N/A	Appearance	white to yellow or yellow-brownish cryst. solid
Safety	26-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Piperazine,1-piperonyl- (7CI,8CI);1-(1,3-Benzodioxolan-5-ylmethyl)piperazine;1-(3,4-Methylenedioxybenzyl)piperazine;1-(4-Piperonyl)piperazine;1-(Benzo[1,3]dioxol-5-ylmethyl)piperazine;1-(Benzodioxol-5-ylmethyl)piperazine;1-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazine;1-[(Benzo[d][1,3]dioxol-5-yl)methyl]piperazine;4-(4-Piperonyl)piperazine;4-[(Benzodioxol-5-yl)methyl]piperazine;5-(Piperazinomethyl)-1,3-benzodioxole;N-Piperonylpiperazine;N-[(1,3-Benzodioxol-5-yl)methyl]piperazine;1-(3,4-Methylenedioxyphenylmethyl)piperazine;	Article Data	15

1-PIPERONYLPIPERAZINE Synthetic route

: 110-85-0
piperazine

: 495-76-1
piperonol

: 32231-06-4
1-Piperonylpiperazine

Conditions

Conditions	Yield
In o-xylene at 150℃; for 30h; Inert atmosphere; Sealed tube;	81%
With aluminum (III) chloride; water In acetonitrile at 20℃; Irradiation;	41%

: 1-(1,3-benzodioxol-5-ylmethyl)-4-[(2-nitrophenyl)methyl]piperazine

: 32231-06-4
1-Piperonylpiperazine

Conditions

Conditions	Yield
With hydrazine In 1,4-dioxane; water Inert atmosphere; UV-irradiation;	80%

: 110-85-0
piperazine

: 120-57-0
piperonal

: 32231-06-4
1-Piperonylpiperazine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tert-butyl methyl ether at 13 - 18℃; High pressure;	78%

: 110-85-0
piperazine

: 20850-43-5
5-(chloromethyl)-1,3-benzodioxole

: 142-64-3
piperazine dihydrochloride

: 32231-06-4
1-Piperonylpiperazine

Conditions

Conditions	Yield
Stage #1: piperazine; piperazine dihydrochloride In ethanol at 65℃; for 1h; Stage #2: 5-(chloromethyl)-1,3-benzodioxole In ethanol at 78℃; for 2h;

: benzyl 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carboxylate

: 32231-06-4
1-Piperonylpiperazine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 2h;

: 724428-97-1
4-chloro-6-dimethylamino-3-methylisoxazolo[5,4-d]pyrimidine

: 32231-06-4
1-Piperonylpiperazine

: 6-dimethylamino-3-methyl-4-(3,4-methylenedioxybenzylpiperazino)isoxazolo[5,4-d]pyrimidine

Conditions

Conditions	Yield
In tetrahydrofuran Heating;	99%

: 24424-99-5
di-tert-butyl dicarbonate

: 32231-06-4
1-Piperonylpiperazine

: 1233143-33-3
tert-butyl 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 1.5h; Inert atmosphere;	99%

: 98-59-9
p-toluenesulfonyl chloride

: 32231-06-4
1-Piperonylpiperazine

: 305859-64-7
1-(benzo[d][1,3]dioxol-5-ylmethyl)-4-tosylpiperazine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 4.5h; Inert atmosphere;	99%

: 124-38-9
carbon dioxide

: 32231-06-4
1-Piperonylpiperazine

: C13H16N2O3

Conditions

Conditions	Yield
With hydrogen In methanol at 120℃; under 30003 Torr; for 24h; Autoclave;	99%

: 762-42-5
dimethyl acetylenedicarboxylate

: 32231-06-4
1-Piperonylpiperazine

: 24726-53-2
tetramethyl 2,2'-(1,4-piperazindiyl)dimaleate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1h;	98%

1-PIPERONYLPIPERAZINE Chemical Properties

IUPAC Name: 1-(1,3-benzodioxol-5-ylmethyl)piperazine
The MF of 1-PIPERONYLPIPERAZINE(32231-06-4): C₁₂H₁₆N₂O₂
The MW of 1-PIPERONYLPIPERAZINE(32231-06-4): 220.27
EINECS: 250-968-5
mp: 36-40 °C(lit.)
bp: 147-149 °C at 2 mm Hg(lit.)
Fp: >230 °F
Density: 1.203 g/cm³
Index of Refraction: 1.577
Appearance: Crystalline mass.
Solubility in water: Very soluble
Categories: Pharmaceutical Raw Materials;Heterocycles;API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperazines
Synonyms: 3,4-METHYLENEDIOXY-1-(N-PIPERAZINYL)-BENZENE;1-PIPERONYLPIPERAZINE;1-[(1,3-BENZODIOXOL-5-YL)METHYL]PIPERAZINE;1-BENZO[1,3]DIOXOL-5-YLMETHYL-PIPERAZINE;1-(3,4-METHYLENEDIOXYBENZYL)PIPERAZINE;1-(3,4-METHYLENDIOXYBENZYL)PIPERAZINE;AKOS BBS-00006443;AKOS B020126
The Structure of 1-PIPERONYLPIPERAZINE(32231-06-4):

1-PIPERONYLPIPERAZINE Toxicity Data With Reference

1. mouse LD50 intraperitoneal 50mg/kg (50mg/kg)
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 555, 1974.

1-PIPERONYLPIPERAZINE Safety Profile

Hazard Codes:

Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
RIDADR: 3259
WGK Germany: 3
RTECS: TM1550000
Hazard Note: Irritant
HazardClass: 8
PackingGroup: II

1-PIPERONYLPIPERAZINE Specification

1. First Aid Measures
Ingestion:
Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
Inhalation:
Remove from exposure to fresh air immediately.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
2. Handling and Storage
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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