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Name	2,4-DiChloro-5-fluoropyrimidine	EINECS	249-616-3
CAS No.	2927-71-1	Density	1.605 g/cm³
PSA	25.78000	LogP	1.92250
Solubility	N/A	Melting Point	37-41 °C(lit.)
Formula	C₄HCl₂FN₂	Boiling Point	222.8 °C at 760 mmHg
Molecular Weight	166.97	Flash Point	88.6 °C
Transport Information	N/A	Appearance	yellow to orange crystalline solid
Safety	26-36-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	5-Fluoro-2,4-dichloropyrimidine;2,4-Dichloro-5-fluorouracil;	Article Data	43

2,4-DiChloro-5-fluoropyrimidine Synthetic route

: 4330-22-7
2,4-dimethoxy-5-fluoropyrimidine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
Stage #1: 5-fluoro-2,4-dimethoxypyrimidine With thionyl chloride In chloroform at 0℃; for 0.5h; UV-irradiation; Stage #2: With chlorine In chloroform at 20℃; for 12h; Solvent; Wavelength; UV-irradiation;	98%

: 51-21-8
5-fluoropyrimidine-2,4-diol

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate In N,N-dimethyl-aniline at 100℃; for 13h; Inert atmosphere; Large scale;	95%
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent);	93%
With dimethyl amine; trichlorophosphate at 95 - 120℃; for 4h;	92%

: 51-21-8
5-fluorouracil

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With dimethyl amine; trichlorophosphate at 95 - 120℃; for 4h;	94%
With phosphorus pentachloride for 4h; Heating;	91%
Stage #1: 5-fluorouracil With trichlorophosphate at 95℃; for 3.5h; Stage #2: With hydrogenchloride In water at 0 - 20℃;	87%

: 6693-08-9
2,4,6-trichloro-5-fluoropyrimidine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With hydrogen; triethylamine; palladium on activated charcoal In ethyl acetate at 30℃; under 2625.2 Torr;	87%

: 74-96-4
ethyl bromide

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran

: 110-91-8
morpholine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 31646-53-4
4-(2-chloro-5-fluoro-pyrimidin-4-yl)morpholine

Conditions

Conditions	Yield
In water at 60 - 70℃; for 2.5h;	100%
With N-ethyl-N,N-diisopropylamine In ethanol Reflux; regioselective reaction;	95%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h; Inert atmosphere; Reflux;	85%

: 110-89-4
piperidine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 40423-82-3
2-chloro-5-fluoro-4-piperidin-1-yl-pyrimidine

Conditions

Conditions	Yield
In water at 60 - 70℃; for 2.5h;	100%

: 21867-64-1
1-n-propylpiperazine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 2-Chloro-5-fluoro-4-(4-propyl-piperazin-1-yl)-pyrimidine

Conditions

Conditions	Yield
In water at 60 - 70℃; for 2.5h;	100%

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 155-10-2
2-chloro-5-fluoropyrimidin-4-amine

Conditions

Conditions	Yield
With ammonium hydroxide at 60 - 70℃; for 2.5h;	100%
With ammonia In water Substitution;
With ammonium hydroxide In ethanol at 25 - 35℃; for 3.5h;

: 956125-05-6
(R)-tert-butyl (1-aminobutan-2-yl)carbamate

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 956125-24-9
{(R)-1-[(2-Chloro-5-fluoro-pyrimidin-4-ylamino)-methyl]-propyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0℃; for 3h;	100%

2,4-DiChloro-5-fluoropyrimidine Chemical Properties

Molecular Structure of 2,4-DiChloro-5-fluoropyrimidine (CAS No.2927-71-1):

Molecular Formula: C₄HCl₂FN₂
Molecular Weight: 166.9685
IUPAC Name: 2,4-Dichloro-5-fluoropyrimidine
CAS No: 2927-71-1
Melting Point: 37-41 ºC
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 25.78 Å²
Index of Refraction: 1.531
Molar Refractivity: 32.21 cm³
Molar Volume: 103.9 cm³
Surface Tension: 48.4 dyne/cm
Density: 1.605 g/cm³
Flash Point: 88.6 °C
Enthalpy of Vaporization: 44.06 kJ/mol
Boiling Point: 222.8 °C at 760 mmHg
Vapour Pressure: 0.148 mmHg at 25°C
Appearance: Yellow to Orange Crystalline Solid
InChI: InChI=1/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChIKey: WHPFEQUEHBULBW-UHFFFAOYAO
Std. InChI: InChI=1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
Std. InChIKey: WHPFEQUEHBULBW-UHFFFAOYSA-N
Product Categories: Pyrimidine Series;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Halides;Pyrazines, Pyrimidines Pyridazines;Pyrimidine;Building Blocks;Fluorinated;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks

2,4-DiChloro-5-fluoropyrimidine Uses

2,4-Dichloro-5-fluoropyrimidine(2927-71-1) is used as intermediate of antifungal flucytosine.

2,4-DiChloro-5-fluoropyrimidine Production

2,4-Dichloro-5-fluoropyrimidine(2927-71-1) can be produced by chloridizing 5-Fluorouracil.

2,4-DiChloro-5-fluoropyrimidine Safety Profile

Safety Information of 2,4-Dichloro-5-fluoropyrimidine(2927-71-1):
Hazard Codes: Irritant Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
37/39:Wear suitable gloves and eye/face protection
WGK Germany:3
Hazard Note:Irritant

2,4-DiChloro-5-fluoropyrimidine Specification

2,4-DiChloro-5-fluoropyrimidine (CAS No.2927-71-1), it also can be called Pyrimidine, 2,4-dichloro-5-fluoro- .

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