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Conditions | Yield |
---|---|
With 2-pentanol; ReOCl3(SMe2)(OPPh3) for 17h; Green chemistry; chemoselective reaction; | 98% |
Multi-step reaction with 3 steps 1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 - 20 °C 2: tris(pentafluorophenyl)borate / 1,2-dichloro-ethane / 0.08 h / 20 °C / Glovebox; Schlenk technique 3: sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane for 2h; Heating; | 91% |
Conditions | Yield |
---|---|
With 2-pentanol; ReOCl3(SMe2)(OPPh3) for 17h; Green chemistry; chemoselective reaction; | 91% |
Conditions | Yield |
---|---|
With potassium bisulfite; potassium chloride; cobalt(II) chloride In water at 70 - 75℃; for 2.33333h; Concentration; Temperature; | 85% |
With nitrosylsulfuric acid; acetic acid Behandlung der erhaltenen Diazoniumsalz-Loesung mit CuCl in konz. wss. HCl; | |
With hydrogenchloride; copper dichloride; sodium nitrite |
2,4-dichlorobenzyl mercaptan
A
2,4-dichlorotoluene
B
bis-(2,4-dichloro-benzyl)-sulfide
C
2,4-dichlorobenzaldeyhde
Conditions | Yield |
---|---|
With tetrafluoroboric acid; triiron dodecarbonyl In benzene 1.) RT, 4 h; 2.) 60 deg C; | A 74% B 2% C 3% D 10% |
Conditions | Yield |
---|---|
With aluminum (III) chloride; iron(III) chloride; chlorine; calcium chloride; zinc(II) chloride In water at 39℃; for 18h; Temperature; Molecular sieve; Autoclave; Inert atmosphere; | 68.9% |
With chlorine at 40 - 41℃; for 0.5h; Temperature; | 68% |
With perchloric acid; trichloroisocyanuric acid In water; acetic acid at 30℃; Rate constant; Thermodynamic data; Ea, ΔH(excit.), ΔS(excit.); |
Conditions | Yield |
---|---|
With tricarbonyl(η(4)-cycloocta-1,5-diene)iron; phenylsilane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; UV-irradiation; chemoselective reaction; | A 67% B n/a |
2,4-dichlorobenzyl mercaptan
2,4-dichlorotoluene
Conditions | Yield |
---|---|
dicobalt octacarbonyl In water; benzene at 185 - 190℃; under 46543.3 Torr; | 63% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hypochlorite In water at 20℃; Product distribution; Further Variations:; Temperatures; molar quantity of reagents; Chlorination; oxidative chlorination; | A 29% B 63% C 3.5% |
With oxone; potassium chloride In acetonitrile at 20℃; for 24h; Product distribution; Further Variations:; Reagents ratio; | |
With sulfuric acid; [BMIM]Cl; chlorine at 70℃; for 8h; |
Conditions | Yield |
---|---|
at 180℃; under 0.5 Torr; for 3h; | A 20% B 45% |
The Molecular Structure of 2,4-Dichlorotoluene (CAS NO.95-73-8):
Empirical Formula: C7H6Cl2
Molecular Weight: 161.0285
Index of Refraction: 1.543
Molar Refractivity: 40.86 cm3
Molar Volume: 129.6 cm3
Surface Tension: 35.6 dyne/cm
Density: 1.242 g/cm3
Flash Point: 79.4 °C
Enthalpy of Vaporization: 41.71 kJ/mol
Boiling Point: 198.6 °C at 760 mmHg
Vapour Pressure: 0.502 mmHg at 25°C
IUPAC Name: 2,4-dichloro-1-methylbenzene
Appearance: clear colorless liquid
Product Categories: Organics;Aryl;C7;Halogenated Hydrocarbons
Synonyms: 2,4-Dichlorotoluene ; 2,4-Dichloro-1-methylbenzene ; 4-05-00-00815 (Beilstein Handbook Reference) ; BRN 1931691 ; Benzene, 2,4-dichloro-1-methyl- ; EINECS 202-445-8 ; HSDB 2567 ; Toluene, 2,4-dichloro- ; Benzene, 2,4-dichloro-1-methyl- ; Toluene, 2,4-dichloro-
2,4-Dichlorotoluene (CAS NO.95-73-8) is used as raw materials for organic synthesis. In medicine industry, 2,4-Dichlorotoluene (CAS NO.95-73-8) is used as high boiling point solvents and for the synthesis of chlorinated-nitrated pesticides and medicinal products. For pesticide intermediates, It is used for manufacture 2,4-dichloro-benzyl chloride , 2,4-Dichlorobenzoyl chloride for synthesis and 2,4-dichloro-benzoic acid .
Through 2.3-chloro-4-toluidine and sodium nitrate's diazo reaction, then through the sandmyer-reaction with copper chloride, we can obtain 2,4-Dichlorotoluene (CAS NO.95-73-8).
1. | orl-rat LD50:4600 mg/kg | GISAAA Gigiena i Sanitariya. 53 (2)(1988),80. | ||
2. | orl-mus LD50:2900 mg/kg | GISAAA Gigiena i Sanitariya. 53 (2)(1988),80. | ||
3. | orl-gpg LD50:5 g/kg | GISAAA Gigiena i Sanitariya. 53 (2)(1988),80. |
Reported in EPA TSCA Inventory.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 23-24/25
S23: Do not breathe vapour
S24/25: Avoid contact with skin and eyes
RIDADR: UN 2810
WGK Germany: 2
RTECS: XT0730000
Hazard Note: Harmful
HazardClass: 9
PackingGroup: III
HS Code: 29036990
ASSAY: 99.0% min
ISOMER IMPURITY: 1.0% max