CAS No.101-02-0,Triphenyl phosphite Suppliers

Products Categories

Pharmaceutical (38)
Organic Chemicals (27)
Catalyst and Auxiliary (22)
Others (15)
Reagent (7)
Materials (2)
(1)
Basic Inorganic Chemicals (1)

Basic Information

Molecular Structure:
CAS No.:	101-02-0
Name:	Triphenyl phosphite
Article Data:	73

Formula:	C₁₈H₁₅O₃P
Molecular Weight:	310.289
Synonyms:	Phenylphosphite ((C6H5O)3P) (6CI,7CI);ADK Stab TPP;Advance TPP;Doverphos 10;Irgafos TPP;Irgastab CH 55;Mark TPP;Mellite 310;Phosclere T 36;Plastistab 2334;Sumilizer TPP-R;Sumilizer TTP-R;TPP (plasticizer);TPP-R;Triphenoxyphosphine;Tris(phenoxy)phosphine;Weston TPP;
EINECS:	202-908-4
Density:	1.184 g/mL at 25 °C(lit.)
Melting Point:	22-24 °C
Boiling Point:	360 °C at 760 mmHg
Flash Point:	218.3 °C
Solubility:	insoluble in water
Appearance:	colourless to pale yellow liquid
Hazard Symbols:	Xn,N,Xi
Risk Codes:	36/38-50/53
Safety:	28-60-61-28A
Transport Information:	UN 3077 9/PG 3
PSA:	41.28000
LogP:	5.45030

Synthetic route

: 108-95-2
phenol

: 101-02-0
triphenyl phosphite

Conditions

Conditions	Yield
With Hexamethylphosphorous triamide In toluene at 130℃; for 8h; Schlenk technique; Sealed tube; Inert atmosphere; regioselective reaction;	100%
With phosphorus trichloride at 35 - 160℃; under 7.50075 Torr; for 6h; Temperature; Flow reactor; Inert atmosphere;	94%
With 1H-imidazole; carbon disulfide; Hexamethylphosphorous triamide In benzene at 20 - 25℃; for 24h;	86%

: triphenylphosphite-borane complex

: 101-02-0
triphenyl phosphite

Conditions

Conditions	Yield
With tert-butyl alcohol; 4 A molecular sieve In tetrahydrofuran at 25℃; for 72h;	100%
With piperazinomethyl polystyrene resin In toluene at 60℃; for 1.5h;

: 4519-35-1
phenylphosphonic acid bis(N,N-diethylamide)

: 62-53-3
aniline

A: 101-02-0
triphenyl phosphite

B: 15159-51-0
N,N',N''-triphenylphosphorous triamide

C: 26350-11-8
phenyl N,N'-diphenylphosphorodiamidite

D: 26350-10-7
diphenyl phenylphosphoramidite

E: 109-89-7
diethylamine

Conditions

Conditions	Yield
for 17h; Product distribution; Heating;	A n/a B n/a C n/a D n/a E 94.5%

...Expand

: 4519-35-1
phenylphosphonic acid bis(N,N-diethylamide)

: 106-40-1
4-bromo-aniline

A: 101-02-0
triphenyl phosphite

B: 109-89-7
diethylamine

C: diphenyl (p-bromophenyl)phosphoramidite

D: phenyl N,N'-bis(p-bromophenyl)phosphorodiamidite

E: N,N',N''-tris(p-bromophenyl)phosphorous triamide

Conditions

Conditions	Yield
for 22h; Product distribution; Heating;	A n/a B 91.4% C n/a D n/a E n/a

...Expand

: 67-56-1
methanol

: 7719-12-2, 52843-90-0
phosphorus trichloride

A: 101-02-0
triphenyl phosphite

B: 18351-42-3
dimethyl phenylphosphonite

C: 7526-26-3
diphenyl methylphosphonate

Conditions

Conditions	Yield
Stage #1: phosphorus trichloride; phenol at 65 - 250℃; for 3 - 4h; Stage #2: methanol; methyl iodide at 210 - 250℃; for 1h; Product distribution / selectivity;	A 4.5% B 4.8% C 85.5%

...Expand

: 139-02-6
sodium phenoxide

: 108-95-2
phenol

: 101-02-0
triphenyl phosphite

Conditions

Conditions	Yield
With tetrachloromethane; phosphorous; 15-crown-5 at 50 - 70℃; for 3h;	85%

: 160067-03-8
2-diethylamino-5-methyl-1,3,2-oxathiaphospholene

: 108-95-2
phenol

: 101-02-0
triphenyl phosphite

Conditions

Conditions	Yield
at 20℃; for 2h;	85%

: 108-95-2
phenol

A: 101-02-0
triphenyl phosphite

B: 115-86-6
phosphoric acid triphenyl ester

Conditions

Conditions	Yield
With pyridine In acetonitrile at 50℃; electrosynthesis;	A 78% B 20%

: 73569-84-3
chlorotriphenoxy(trichloroacetyl)phosphorane

A: 101-02-0
triphenyl phosphite

B: 5382-00-3
Diphenyl phosphorochloridite

C: 76-02-8
Trichloroacetyl chloride

Conditions

Conditions	Yield
at 50℃; under 10 Torr; Mechanism;	A n/a B n/a C 63.6%

...Expand

: 3582-11-4
trichloromethylphosphonous dichloride

: 108-95-2
phenol

A: 101-02-0
triphenyl phosphite

B: 67-66-3
chloroform

C: 115-86-6
phosphoric acid triphenyl ester

Conditions

Conditions	Yield
	A 55.6% B 34% C 6.7%

...Expand

Raw Materials

67-56-1

71-43-2

Downstream Products

756-79-6

93-99-2

882-33-7

42022-83-3

617-94-7

130727-16-1

115-86-6

7664-38-2

Total:96 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 101-02-0

Chemistry

Molecular Structure of Triphenyl phosphite (CAS NO.101-02-0):

IUPAC Name: triphenyl phosphite
Empirical Formula: C₁₈H₁₅O₃P
Molecular Weight: 310.2837
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 6
Polar Surface Area: 41.28 Å²
Flash Point: 218.3 °C
Enthalpy of Vaporization: 58.18 kJ/mol
Boiling Point: 360 °C at 760 mmHg
Denny: 1.184 g/mL at 25 °C(lit.)
Vapour Pressure: 4.74E-05 mmHg at 25°C
Water solubility: insoluble
Melting point: 22-24 ºC
EINECS: 202-908-4
Sensitive: Air & Moisture Sensitive
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Product Categories: Catalysis and Inorganic Chemistry; Phosphite Ligands; Phosphorus Compounds
InChI
InChI=1/C18H15O3P/c1-4-10-16(11-5-1)19-22(20-17-12-6-2-7-13-17)21-18-14-8-3-9-15-18/h1-15H
Smiles
P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1

Uses

Chemical intermediate, stabilizer systems for resins, metal scavenger, diluent for epoxy resins.

Production

Triphenyl phosphite is prepared from phosphorus trichloride and phenol in the presence of a base:
PCl₃ + 3 HOC₆H₅→ P(OC₆H₅)₃ + 3HCl
Trimethyl phosphine is prepared from triphenylphosphite:
3 CH₃MgBr + P(OC₆H₅)₃ → P(CH₃)₃ + 3 MgBrOC₆H₅

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	100mg/kg (100mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	National Technical Information Service. Vol. OTS0570901,
cat	LDLo	subcutaneous	300mg/kg (300mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 78, 1933.
chicken	LDLo	intravenous	50mg/kg (50mg/kg)	AUTONOMIC NERVOUS SYSTEM: GAGLION BLOCK	Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 44, Pg. 118, 1989.
chicken	LDLo	oral	250mg/kg (250mg/kg)	BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0532280,
chicken	LDLo	subcutaneous	375mg/kg (375mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0532280,
mammal (species unspecified)	LD50	intraperitoneal	250mg/kg (250mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.
mouse	LD50	intraperitoneal	266mg/kg (266mg/kg)		Agricultural and Biological Chemistry. Vol. 31, Pg. 1288, 1967.
mouse	LD50	oral	1080mg/kg (1080mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(12), Pg. 53, 1987.
mouse	LD50	unreported	1360mg/kg (1360mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(9), Pg. 55, 1977.
rabbit	LDLo	skin	5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0532280,
rat	LC	inhalation	> 6700mg/m³/1H (6700mg/m³)		National Technical Information Service. Vol. OTS0532280,
rat	LD50	intraperitoneal	250mg/kg (250mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1117, 1986.
rat	LD50	oral	444mg/kg (444mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(12), Pg. 13, 1981.
rat	LD50	unreported	1490mg/kg (1490mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(9), Pg. 55, 1977.
rat	LDLo	subcutaneous	2gm/kg (2000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 78, 1933.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. An experimental eye and severe human skin irritant. Combustible when exposed to heat or flame. To fight fire, use CO₂, mist, dry chemical. When heated to decomposition, it emits toxic fumes of PO_x. See also Phenol.
Hazard Codes: Harmful Xn Dangerous N,Xi
Risk Statements: 36/38-50/53
R36/38:Irritating to eyes and skin.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 28-60-61-28A
S28:After contact with skin, wash immediately with plenty of soap-suds.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
RTECS: TH1575000
HazardClass: 9
PackingGroup: III
HS Code: 29209085

Specification

Triphenyl phosphite , with CAS number of 101-02-0, can be called phosphorous acid, triphenyl ester ; Advance TPP ; Phenyl phosphite ; Sumilizer TPP-R ; Trifenoxyfosfin ; Tris(phenoxy)phosphine . It is a colourless to pale yellow liquid, be insoluble in water. Triphenyl phosphite (CAS NO.101-02-0) are susceptible to form highly toxic and flammable phosphine gas in the presence of strong reducing agents, such as hydrides. Partial oxidation may result in the release of toxic phosphorus oxides.