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Cas Database |
| Name |
2-Chloro-4-cyanopyridine |
EINECS | -0 |
| CAS No. | 33252-30-1 | Density | 1.33 g/cm3 |
| PSA | 36.68000 | LogP | 1.60668 |
| Solubility | N/A | Melting Point |
69-73 °C(lit.) |
| Formula | C6H3ClN2 | Boiling Point | 218.9 °C at 760 mmHg |
| Molecular Weight | 138.556 | Flash Point | 86.2 °C |
| Transport Information | N/A | Appearance | white or light yellow crystal |
| Safety | 26-36-36/37/39 | Risk Codes | 36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
2-Chloroisonicotinonitrile;2-chloropyridine-4-carbonitrile; |
Article Data | 12 |
2-Chloro-4-cyanopyridine Synthetic route
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction; | 89% |
- 14906-59-3
4-cyanopyridine N-oxide
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 100℃; for 24h; | 69% |
| With triethylamine; trichlorophosphate In 1,2-dichloro-ethane for 4h; | 117.5 g |
| Conditions | Yield |
|---|---|
| With sulfuric acid; copper(II) sulfate; sodium nitrite Diazotization.weitere Reagentien: Kupfer-Pulver, wss. Na2CO3; |
- 38557-82-3
4-pyridine carboxamide 1-oxide
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride; trichlorophosphate |
- 38557-82-3
4-pyridine carboxamide 1-oxide
- 10026-13-8, 874483-75-7
phosphorus pentachloride
- 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate
- 33252-30-1
2-chloro-4-pyridinenitrile
- 2402-95-1
2-chloropyridine-N-oxide
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: concentrated sulfuric acid; nitric acid 2: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 3: NaNO2; aqueous H2SO4; CuSO4 / Diazotization.weitere Reagentien: Kupfer-Pulver, wss. Na2CO3 View Scheme |
- 14432-16-7
2-chloro-4-nitropyridine-N-oxide
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 2: NaNO2; aqueous H2SO4; CuSO4 / Diazotization.weitere Reagentien: Kupfer-Pulver, wss. Na2CO3 View Scheme |
- 1453-82-3
isonicotinamide
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: aqueous H2O2; acetic acid 2: POCl3; PCl5 View Scheme |
| Conditions | Yield |
|---|---|
| With sodium hydroxide; trichlorophosphate In n-heptane |
- 14906-59-3
4-cyanopyridine N-oxide
- 10026-13-8, 874483-75-7
phosphorus pentachloride
- 33252-30-1
2-chloro-4-pyridinenitrile
| Conditions | Yield |
|---|---|
| With trichlorophosphate | 8.4 g (24%) |
2-Chloro-4-cyanopyridine Chemical Properties
IUPAC Name: 2-chloropyridine-4-carbonitrile
2-Chloro-4-cyanopyridine(33252-30-1),its Molecular formula: C6H3ClN2
2-Chloro-4-cyanopyridine(33252-30-1),its Molar mass: 138.55
Melting point: 69-73 °C(lit.)
Boiling Point: 104-106°C at 15mm
Appearance: White crystalline powder.
Synonyms: 4-CYANO-2-CHLORO PYRIDINE;2-CHLORO-4-PYRIDINECARBONITRILE;2-CHLOROPYRIDINE-4-CARBONITRILE;2-CHLORO-4-CYANOPYRIDINE 2-CHLORO-ISONICOTINONITRILE 2-CHLOROISONICOTINONITRILE
Following is the molecular formula of 2-Chloro-4-cyanopyridine(33252-30-1):
2-Chloro-4-cyanopyridine Uses
2-Chloro-4-cyanopyridine Safety Profile
Hazard Codes :Xi,Xn (Irritant;Harmful):
RIDADR 3276
WGK Germany : 3
Risk Statements :
R36/37/38:Irritating to eyes, respiratory system and skin
R20/21/22 :Harmful by inhalation, in contact with skin and if swallowed
Safety Statements :
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection
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