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| CAS No.: | 14432-12-3 |
|---|---|
| Name: | 4-Amino-2-chloropyridine |
| Article Data: | 23 |
| Molecular Structure: | |
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|
|
| Formula: | C5H5ClN2 |
| Molecular Weight: | 128.561 |
| Synonyms: | 2-chloro-1H-pyridin-4-amine;2-chloro-4-aminopyridine;2-Chloropyridin-4-amine;2-Chloro-4-Pyridinamine;2-Chloro-4-Amino pyridine;2-chloro-pyridin-4-ylamine;2-chloro-4,5-difluoro Benzoic acid; |
| EINECS: | 238-403-0 |
| Density: | 1.326 g/cm3 |
| Melting Point: | 90-94 °C(lit.) |
| Boiling Point: | 299.9 °C at 760 mmHg |
| Flash Point: | 135.2 °C |
| Solubility: | Slightly soluble in water. |
| Appearance: | White powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36/37/39 |
| PSA: | 38.91000 |
| LogP: | 1.89840 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
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- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
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- 50288-62-5threo-Phenyl-2-piperidyl acetamide
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 23056-36-2
2-chloro-4-nitropyridine
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| With titanium for 0.25h; | 98% |
| With [Zn(BH4)2(py)] In tetrahydrofuran for 2h; Heating; | 96% |
| With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; chemoselective reaction; | 95% |
- 14432-16-7
2-chloro-4-nitropyridine-N-oxide
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| With hydrogenchloride; iron In ethanol for 3h; Reduction; Heating; | 95% |
| With hydrogen; Ra-Ni In methanol | 90% |
| With hydrogenchloride; iron In ethanol; water Reflux; | 85% |
- 26452-80-2
2,4-dichloropyridine
A
- 19798-80-2
2-Amino-4-chloropyridine
B
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 170 - 180℃; | |
| With ammonium hydroxide at 180℃; |
- 70696-29-6
2-chloroisonicotinoyl azide
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| With acetic acid |
- 26452-80-2
2,4-dichloropyridine
A
- 19798-80-2
2-Amino-4-chloropyridine
B
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| at 180℃; |
- 109-09-1
2-chloropyridine
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 91 percent / aq. H2O2 / trifluoroacetic acid / 4 h 2: 72 percent / aq. HNO3, H2SO4 / 2 h 3: 95 percent / iron powder, aq. HCl / ethanol / 3 h / Heating View Scheme | |
| Multi-step reaction with 3 steps 1: 30percent aq. H2O2, AcOH / 48 h / 60 °C 2: HNO3, conc. H2SO4 / 2.5 h / 90 °C 3: 90 percent / H2 / Ra-Ni / methanol View Scheme | |
| Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2: nitric acid; sulfuric acid / 90 °C 3: iron; hydrogenchloride / ethanol; water / Reflux View Scheme | |
| Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 h / 25 °C 2: sulfuric acid; nitric acid / 0 - 100 °C 3: iron; hydrogenchloride / ethanol; water / Reflux View Scheme |
- 2402-95-1
2-chloropyridine-N-oxide
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 72 percent / aq. HNO3, H2SO4 / 2 h 2: 95 percent / iron powder, aq. HCl / ethanol / 3 h / Heating View Scheme | |
| Multi-step reaction with 2 steps 1: HNO3, conc. H2SO4 / 2.5 h / 90 °C 2: 90 percent / H2 / Ra-Ni / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: concentrated sulfuric acid; nitric acid 2: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 View Scheme | |
| Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 90 °C 2: iron; hydrogenchloride / ethanol; water / Reflux View Scheme |
- 1124-33-0
4-nitraminopyridine N-oxide
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sulfuryl chloride / 110 °C 2: aqueous NH3 / 180 °C View Scheme |
- 626-03-9
3-deazauracil
- 14432-12-3
4-Amino-2-chloropyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: phosphoryl chloride / 140 °C 2: aqueous NH3 / 180 °C View Scheme |
| Conditions | Yield |
|---|---|
| With potassium hydroxide; iron; acetic acid In diethyl ether; ethanol; water; Petroleum ether |
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Specification
The 2-Chloro-4-Pyridinamine, with its CAS registry number 14432-12-3, has the IUPAC name of 2-chloropyridin-4-amine. This is a kind of white powder, and its product categories are including Pyridine; Fine Chemical & Intermediates; Amines; blocks; Pyridines, Pyrimidines, Purines and Pteredines; Chloropyridines; Halopyridines; Halogenated Heterocycles; Heterocyclic Building Blocks. When comes to its usage, it is often used as in the application of medicine, pesticide intermediates and pigment, and it could also be used as an additive of plant growth regulator.
The characteristics of this chemical are as below: (1)ACD/LogP: 1.21; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.15; (4)ACD/LogD (pH 7.4): 1.21; (5)ACD/BCF (pH 5.5): 4.21; (6)ACD/BCF (pH 7.4): 4.92; (7)ACD/KOC (pH 5.5): 93.06; (8)ACD/KOC (pH 7.4): 108.74; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 16.13; (13)Index of Refraction: 1.607; (14)Molar Refractivity: 33.47 cm3; (15)Molar Volume: 96.8 cm3; (16)Polarizability: 13.27×10-24 cm3; (17)Surface Tension: 54.3 dyne/cm; (18)Density: 1.326 g/cm3; (19)Flash Point: 135.2 °C; (20)Enthalpy of Vaporization: 53.99 kJ/mol; (21)Boiling Point: 299.9 °C at 760 mmHg; (22)Vapour Pressure: 0.00116 mmHg at 25°C; (23)Exact Mass: 128.014126; (24)MonoIsotopic Mass: 128.014126; (25)Topological Polar Surface Area: 38.9; (26)Heavy Atom Count: 8; (27)Complexity: 76.8.
When you are using this chemical, you should be very careful. For being irritating to eyes, respiratory system and skin, this chemical may cause inflammation to the skin or other mucous membranes. Due to the above hazard information, you should wear suitable protective clothing, gloves and eye/face protection. And if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
What's more, the following datas could be converted into the molecular structure:
(1)Canonical SMILES: C1=CN=C(C=C1N)Cl
(2)InChI: InChI=1S/C5H5ClN2/c6-5-3-4(7)1-2-8-5/h1-3H,(H2,7,8)
(3)InChIKey: BLBDTBCGPHPIJK-UHFFFAOYSA-N