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Name |
3,5-Diiodo-L-tyrosine |
EINECS | 206-092-0 |
CAS No. | 300-39-0 | Density | 2.405 g/cm3 |
PSA | 102.01000 | LogP | 2.12750 |
Solubility | slightly soluble | Melting Point |
200°C (dec.)(lit.) |
Formula | C9H9I2NO3 | Boiling Point | 410.5 °C at 760 mmHg |
Molecular Weight | 432.984 | Flash Point | 202.1 °C |
Transport Information | N/A | Appearance | white to beige powder |
Safety | 26-37/39-36/37-24/25 | Risk Codes |
Xi:Irritant; |
Molecular Structure | Hazard Symbols | R36/37/38:; | |
Synonyms |
Tyrosine,3,5-diiodo-, L- (8CI);3',5'-Diiodo-L-tyrosine;Bijodtyrosin;DIT (amino acid);L-3,5-Diiodotyrosine;NSC 4143;H-Tyr(3,5-Di-I)-OH; |
Article Data | 20 |
Conditions | Yield |
---|---|
With hydrogen iodide; acetic acid In dimethyl sulfoxide at 65℃; for 0.025h; | 84.63% |
With iodine; ethylamine; sodium iodide In water for 0.666667h; | 73.5% |
With ammonium hydroxide; iodine; potassium iodide |
Conditions | Yield |
---|---|
With chloroamine-T; sodium iodide In water at 20℃; for 0.00277778h; Product distribution; other reaction time, pregenerated iodine, reaction in the presence of tryptophan and Nin-formyl-tryptophan; | A 38.6% B 32.6% |
With iodide; dihydrogen peroxide; lactoperoxidase |
Conditions | Yield |
---|---|
With iodine In water at 22℃; for 0.0833333h; potassim iodide/chloramine T in phosphate buffer instead of iodine; tritium isotope effect; |
Conditions | Yield |
---|---|
With sulfuryl dichloride at 0 - 20℃; Inert atmosphere; | 100% |
With hydrogenchloride at 60℃; for 0.0416667h; Microwave irradiation; | 74.63% |
With hydrogenchloride | |
With thionyl chloride |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; water at 20℃; Condensation; | 100% |
Conditions | Yield |
---|---|
Stage #1: 3,5-diiodo-l-tyrosine With sodium hydroxide In water for 1h; Stage #2: copper(II) sulfate In water at 20 - 40℃; for 2h; | 98% |
methanol
3,5-diiodo-l-tyrosine
3,5-diiodo-L-tyrosine methyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: methanol With thionyl chloride at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 3,5-diiodo-l-tyrosine at 20℃; for 16h; | 98% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 24℃; for 16h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH); | 94% |
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 1h; Time; | 93.7% |
Systematic Name: 3,5-Diiodo-L-tyrosine dihydrate
Synonyms of 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0): 3,5-Iodo-L-tyrosine ; 3,5-L-Diiodotyrosine ; L-3,5-Diiodotyrosine ; L-Tyrosine, 3,5-diiodo- ; Tyrosine, 3,5-diiodo-, L- (8CI)
CAS NO: 300-39-0
Molecular Formula: C9H9I2NO3.2(H2O)
Molecular Weight: 469.01
Molecular Structure:
EINECS: 206-092-0
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 38.77 Å2
Flash Point: 202.1 °C
Enthalpy of Vaporization: 69.9 kJ/mol
Boiling Point: 410.5 °C at 760 mmHg
Vapour Pressure: 1.78E-07 mmHg at 25°C
Melting point: 200 °C (dec.)(lit.)
Alpha: -20.7 º (c=2.5, 0.1N NaOH/H2O)
Refractive index: 1.2 ° (C=5, 1mol/L HCl)
Storage temp: 2-8°C
Water Solubility: slightly soluble
Appearance: white to beige powder
Product Categoriesof 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0): Pharmaceutical Raw Materials;Amino Acids;Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids
Safety Information about 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0):
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2811
WGK Germany: 3
F: 8