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3,5-Diiodo-L-tyrosine

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Name

3,5-Diiodo-L-tyrosine

EINECS 206-092-0
CAS No. 300-39-0 Density 2.405 g/cm3
PSA 102.01000 LogP 2.12750
Solubility slightly soluble Melting Point 200°C (dec.)(lit.)
Formula C9H9I2NO3 Boiling Point 410.5 °C at 760 mmHg
Molecular Weight 432.984 Flash Point 202.1 °C
Transport Information N/A Appearance white to beige powder
Safety 26-37/39-36/37-24/25 Risk Codes  Xi:Irritant;
Molecular Structure Molecular Structure of 300-39-0 (3,5-Diiodo-L-tyrosine dihydrate) Hazard Symbols R36/37/38:;
Synonyms

Tyrosine,3,5-diiodo-, L- (8CI);3',5'-Diiodo-L-tyrosine;Bijodtyrosin;DIT (amino acid);L-3,5-Diiodotyrosine;NSC 4143;H-Tyr(3,5-Di-I)-OH;

Article Data 20

3,5-Diiodo-L-tyrosine Synthetic route

60-18-4

L-tyrosine

300-39-0

3,5-diiodo-l-tyrosine

Conditions
ConditionsYield
With hydrogen iodide; acetic acid In dimethyl sulfoxide at 65℃; for 0.025h;84.63%
With iodine; ethylamine; sodium iodide In water for 0.666667h;73.5%
With ammonium hydroxide; iodine; potassium iodide
60-18-4

L-tyrosine

A

300-39-0

3,5-diiodo-l-tyrosine

B

70-78-0

3-Iodo-L-tyrosine

Conditions
ConditionsYield
With chloroamine-T; sodium iodide In water at 20℃; for 0.00277778h; Product distribution; other reaction time, pregenerated iodine, reaction in the presence of tryptophan and Nin-formyl-tryptophan;A 38.6%
B 32.6%
With iodide; dihydrogen peroxide; lactoperoxidase
70-78-0

3-Iodo-L-tyrosine

300-39-0

3,5-diiodo-l-tyrosine

Conditions
ConditionsYield
With iodine In water at 22℃; for 0.0833333h; potassim iodide/chloramine T in phosphate buffer instead of iodine; tritium isotope effect;
7664-41-7

ammonia

7553-56-2

iodine

60-18-4

L-tyrosine

300-39-0

3,5-diiodo-l-tyrosine

67-56-1

methanol

300-39-0

3,5-diiodo-l-tyrosine

76318-50-8

3,5-diiodo-L-thyrosine methyl ester

Conditions
ConditionsYield
With sulfuryl dichloride at 0 - 20℃; Inert atmosphere;100%
With hydrogenchloride at 60℃; for 0.0416667h; Microwave irradiation;74.63%
With hydrogenchloride
With thionyl chloride
3392-12-9

Boc-Val-ONSu

300-39-0

3,5-diiodo-l-tyrosine

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water at 20℃; Condensation;100%
300-39-0

3,5-diiodo-l-tyrosine

7758-99-8

copper(II) sulfate

3,5-diiodo L-tyrosine copper complex

Conditions
ConditionsYield
Stage #1: 3,5-diiodo-l-tyrosine With sodium hydroxide In water for 1h;
Stage #2: copper(II) sulfate In water at 20 - 40℃; for 2h;
98%
67-56-1

methanol

300-39-0

3,5-diiodo-l-tyrosine

151266-48-7

3,5-diiodo-L-tyrosine methyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: methanol With thionyl chloride at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 3,5-diiodo-l-tyrosine at 20℃; for 16h;
98%
300-39-0

3,5-diiodo-l-tyrosine

5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one

51-48-9

L-thyroxine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 24℃; for 16h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH);94%

copper(II) sulfate heptahydrate

300-39-0

3,5-diiodo-l-tyrosine

49553-16-4

{Cu(HOC6H2I2CH2CH(NH2)COO)2}

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 1h; Time;93.7%

3,5-Diiodo-L-tyrosine Chemical Properties

Systematic Name: 3,5-Diiodo-L-tyrosine dihydrate
Synonyms of 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0): 3,5-Iodo-L-tyrosine ; 3,5-L-Diiodotyrosine ; L-3,5-Diiodotyrosine ; L-Tyrosine, 3,5-diiodo- ; Tyrosine, 3,5-diiodo-, L- (8CI)
CAS NO: 300-39-0
Molecular Formula: C9H9I2NO3.2(H2O)
Molecular Weight: 469.01
Molecular Structure:
EINECS: 206-092-0 
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 38.77 Å2 
Flash Point: 202.1 °C
Enthalpy of Vaporization: 69.9 kJ/mol
Boiling Point: 410.5 °C at 760 mmHg
Vapour Pressure: 1.78E-07 mmHg at 25°C
Melting point: 200 °C (dec.)(lit.)
Alpha: -20.7 º  (c=2.5, 0.1N NaOH/H2O)
Refractive index: 1.2 ° (C=5, 1mol/L HCl)
Storage temp: 2-8°C
Water Solubility: slightly soluble
Appearance: white to beige powder
Product Categoriesof 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0): Pharmaceutical Raw Materials;Amino Acids;Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids

3,5-Diiodo-L-tyrosine Safety Profile

Safety Information about 3,5-Diiodo-L-tyrosine dehydrate (CAS NO.300-39-0):
Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2811
WGK Germany: 3
F: 8

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