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Name	3-Methylamino-1-phenylpropan-1-one hydrochloride	EINECS	C10H14ClNO
CAS No.	2538-50-3	Density	1.002g/cm³
PSA	29.10000	LogP	2.67170
Solubility	N/A	Melting Point	139-141 °C(Solv: acetone (67-64-1))
Formula	C₁₀H₁₄N.ClH	Boiling Point	274.7°C at 760 mmHg
Molecular Weight	199.68	Flash Point	114.1°C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (9CI);Propiophenone,3-(methylamino)-, hydrochloride (6CI,7CI,8CI);3-(N-Methylamino)propiophenone hydrochloride;3-Methylaminopropiophenone;	Article Data	6

3-Methylamino-1-phenylpropan-1-one hydrochloride Synthetic route

: 50-00-0
formaldehyd

: 593-51-1
methylamine hydrochloride

: 98-86-2
acetophenone

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 110℃; for 20h; Sealed tube;	70%
With hydrogenchloride In ethanol; water at 110℃; for 20h;	39.8%
With hydrogenchloride In ethanol at 110℃;
With toluene-4-sulfonic acid In ethanol at 110℃; for 20h;

: 879-72-1
3-(dimethylamino)propiophenone hydrochloride

suitable amine: suitable amine

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction;	93%
Multi-step reaction with 2 steps 1: potassium borohydride / tetrahydrofuran / 66 °C 2: sodium hydrogencarbonate / chloroform; water View Scheme

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 114133-37-8
(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions

Conditions	Yield
With Rh[((S,S)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 20h; Autoclave; enantioselective reaction;	92%
With hydrogen; potassium carbonate; [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h;	90%
With [Rh((S,S)-BenzP*)(cod)]SbF6; hydrogen; magnesium sulfate; potassium carbonate In ethyl acetate at 50℃; under 37503.8 Torr; for 1h; enantioselective reaction;	80%

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 1h;	90%
With sodium tetrahydroborate In methanol at 20℃; for 1h;

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 57256-92-5
3-methylamino-1-phenyl-propan-1-ol; hydrochloride

Conditions

Conditions	Yield
With potassium borohydride In tetrahydrofuran at 66℃;	82%

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4 / methanol / 1 h / 20 °C 2: CH2Cl2 / 0.17 h / 0 °C View Scheme

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: (S)-N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Rh[((S,S)-BenzP*)(cod)]SbF6; zinc(II) chloride; caesium carbonate; hydrogen / methanol / 20 h / 20 °C / 19001.3 Torr / Autoclave 2: dichloromethane / 0.17 h / 0 °C View Scheme

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 54910-89-3, 57226-07-0, 100568-02-3, 100568-03-4, 59333-67-4
FLUOXETINE

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 55 °C / Inert atmosphere 2.2: 1 h / 90 °C View Scheme

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 1254705-11-7
4-(3-(methylamino)-1-phenylpropyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2: trifluoroacetic acid / 48 h / 20 °C View Scheme

3-Methylamino-1-phenylpropan-1-one hydrochloride Chemical Properties

IUPAC Name: 3-(Methylamino)-1-phenylpropan-1-one chloride
Synonyms of 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3): 3-Methylamino-1-phenylpropan-1-one hydrochloride ;3-(Methylamino)-1-phenyl-1-propanone hydrochloride
CAS NO: 2538-50-3
Molecular Formula of 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3): C₁₀H₁₄ClNO
Molecular Weight: 199.67726
Molecular Structure:

SMILES: CNCCC(=O)c1ccccc1.Cl
InChI: InChI=1/C10H13NO.ClH/c1-11-8-7-10(12)9-5-3-2-4-6-9;/h2-6,11H,7-8H2,1H3;1H
InChIKey: VIHLSOFMDHEDRK-UHFFFAOYAP
Std. InChI: InChI=1S/C10H13NO.ClH/c1-11-8-7-10(12)9-5-3-2-4-6-9;/h2-6,11H,7-8H2,1H3;1H
Std. InChIKey: VIHLSOFMDHEDRK-UHFFFAOYSA-N

3-Methylamino-1-phenylpropan-1-one hydrochloride Uses

1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3) is used as antidepressant fluoxetine intermediate.

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