Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

4'-Aminoacetophenone

Related Products

Hot Products

Name

4'-Aminoacetophenone

EINECS 202-801-2
CAS No. 99-92-3 Density 1.096 g/cm3
PSA 43.09000 LogP 2.05260
Solubility It is soluble in hot water, ethanol and ether. Melting Point 103-107 °C(lit.)
Formula C8H9NO Boiling Point 294.8 °C at 760 mmHg
Molecular Weight 135.166 Flash Point 132.1 °C
Transport Information N/A Appearance slightly yellow to brown crystalline powder
Safety 26-36 Risk Codes 22-36/37/38-20/21/22
Molecular Structure Molecular Structure of 99-92-3 (4-Aminoacetophenone) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

Acetophenone,4'-amino- (8CI);Acetophenone, p-amino- (3CI);1-(4-Aminophenyl)ethanone;1-Acetyl-4-aminobenzene;4-Acetylaniline;4-Acetylphenylamine;4-Aminophenylmethyl ketone;NSC 3242;p-Acetylaniline;p-Acetylphenylamine;p-Aminoacetophenone;p-Aminoacetylbenzene;p-Aminophenylmethyl ketone;4-Aminoacetophenone;

Article Data 368

4'-Aminoacetophenone Synthetic route

100-19-6

(4-nitrophenyl)ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrogen In methanol at 20℃; under 760.051 Torr; for 9h;100%
With hydrogenchloride; ammonium chloride In tetrahydrofuran; water at 45℃; for 2h; Sealed tube; Green chemistry;100%
With hydrogen In water at 50℃; under 750.075 Torr; for 1.5h;100%
83810-18-8

4-(2-methyl-1,3-dithian-2-yl)aniline

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With dihydrogen peroxide; iodine; sodium dodecyl-sulfate In water at 20℃; for 0.333333h; Micellar solution;100%
With Methylthio(bismethylthio)sulfonium hexachloroantimonate In dichloromethane at -77℃; for 0.0166667h;97%
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; dihydrogen peroxide In water; acetonitrile at 20℃; for 0.5h;96%
With hydrogen bromide; dihydrogen peroxide In acetonitrile at 25℃; for 6h;95%
14235-81-5

4-Ethynylaniline

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With gold(III) tribromide; water at 200℃; for 0.333333h; microwave irradiation;100%
With 5,10,15-tris(pentafluorophenyl)corrole cobalt(III) triphenyl phosphine; sulfuric acid; water In methanol at 80℃; for 12h;99%
With trifluorormethanesulfonic acid; water In 2,2,2-trifluoroethanol at 25 - 70℃; for 45h; Sealed tube; regioselective reaction;89%
1321455-52-0

1-(4-(tert-butyldimethylsilylamino)phenyl)ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With silica gel In ethanol; water at 20℃; for 2h;100%
20062-24-2

4-azidoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 20℃; chemoselective reaction;99%
With hydrogen; palladium In methanol; N,N-dimethyl-formamide at 20℃; under 6080.41 Torr; for 8h; Solvent; Temperature; Pressure; Inert atmosphere;99%
With ammonium hydroxide at 90℃; for 0.666667h;95%
13329-40-3

4-Iodoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With ammonium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine In dimethyl sulfoxide at 130℃; for 5h; Reagent/catalyst; Time; Sealed tube; Inert atmosphere;99%
Stage #1: 4-Iodoacetophenone With potassium phosphate; 2,2,2-trifluoroacetamide; N,N`-dimethylethylenediamine; copper(l) iodide In N,N-dimethyl-formamide at 45℃;
Stage #2: With methanol In N,N-dimethyl-formamide at 45℃; Further stages.;
98%
Stage #1: 4-Iodoacetophenone With copper(l) iodide; D-glucosamine hydrochloride; potassium carbonate In water; acetone at 90℃; for 0.166667h;
Stage #2: With ammonia In water; acetone at 90℃; for 28h;
96%
93453-80-6, 14572-89-5

1-(4-aminophenyl)ethanol

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With silica-supported Jones reagent In dichloromethane for 0.00269444h;98.8%
With bromopentacarbonylmanganese(I); N-methyl-N,N-di(2-pyridylmethyl)amine; acetone; sodium t-butanolate In toluene at 90℃; for 2h; Inert atmosphere; Schlenk technique; Darkness;98%
With N-Bromosuccinimide; β‐cyclodextrin In methanol; water; acetone at 20℃; for 10h;95%
103-84-4

Acetanilid

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With aluminium trichloride for 0.05h; Fries rearrangement; microwave irradiation;97%
With ytterbium trifluoromethanesulfonate; lithium perchlorate In nitromethane at 100℃; for 8h; Fries rearrangement;44%
With acetic anhydride; zinc(II) chloride
99-90-1

para-bromoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;97%
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 4h;97%
With ammonium hydroxide; potassium phosphate; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-2-methylpropan-1-one; copper(I) bromide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; Sealed tube;96%
232597-42-1

tert-butyl 4-acetylphenylcarbamate

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With water at 100℃; for 2.5h;97%

4'-Aminoacetophenone Chemical Properties

p-Aminoacetophenone(99-92-3) exists as exists as yellow needle-like crystals with a special aromatic odor. p-Aminoacetophenone(99-92-3) is soluble in hot water, Alcohol, ether, dilute hydrochloric acid and dilute sulphuric acid, lightly soluble in benzene and cold water.
Molecular Structure:
Molecular Formula: C8H9NO.
Molecular Weight: 135.17.
Density: 1.451g/cm3.
Melting Point: 105 - 107 ℃.
Boiling Point: 293 ℃ at 760 mmHg
Flash Point: 94.3 ℃.

4'-Aminoacetophenone Uses

p-Aminoacetophenone(99-92-3) is mainly used as intermediate of antitussive drugs. p-Aminoacetophenone(99-92-3) is also used to determine Palladium and Vitamin B1.

4'-Aminoacetophenone Toxicity Data With Reference

1.   

ipr-mus LD50:381 mg/kg

   GEPHDP    General Pharmacology. 14 (1983),465. NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
2.   

ipr-rat LD50:260 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 80 (1944),31.
3.   

orl-mus LD50:596 mg/kg

   GEPHDP    General Pharmacology. 14 (1983),465.
4.   

ipr-mus LD50:300 mg/kg

   NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
5.   

orl-bwd LD50:133 mg/kg

   AECTCV    Archives of Environmental Contamination and Toxicology. 12 (1983),355.

4'-Aminoacetophenone Consensus Reports

Reported in EPA TSCA Inventory.

4'-Aminoacetophenone Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also AROMATIC AMINES.
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
22: Harmful if swallowed 
36/37/38: Irritating to eyes, respiratory system and skin 
20/21/22: Harmful by inhalation, in contact with skin and if swallowed 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36: Wear suitable protective clothing 
WGK Germany: 3
RTECS: AM5500000
TSCA: T
HS Code: 29223900
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 99-92-3