- 6-Chloronicotinic acid
- 6-Chloronicotinic acid tert-butyl ester
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Cas Database |
| Name |
6-Chloronicotinic acid |
EINECS | 226-201-5 |
| CAS No. | 5326-23-8 | Density | 1.47 g/cm3 |
| PSA | 50.19000 | LogP | 1.43320 |
| Solubility | Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform. | Melting Point |
190 °C (dec.)(lit.) |
| Formula | C6H4ClNO2 | Boiling Point | 330.1 °C at 760 mmHg |
| Molecular Weight | 157.556 | Flash Point | 153.4 °C |
| Transport Information | N/A | Appearance | Off-white to beige crystalline powder |
| Safety | 26-36-24/25-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
6-Chloro-3-pyridinecarboxylic acid;6-chloropyridine-3-carboxylate;6-chloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-;6-Cholre Nicotinic Acid;6-Chloro nicotinic acid; |
Article Data | 30 |
6-Chloronicotinic acid Synthetic route
| Conditions | Yield |
|---|---|
| With hydrogenchloride pH=2; pH-value; | 98% |
| With phosphorus pentachloride; trichlorophosphate at 120 - 130℃; |
- 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine
- 5326-23-8
6-Chloro-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| In sulfuric acid | 94% |
| With sulfuric acid; lithium acetate; water; silver; fluorosulphonic acid; acetic acid In methanol at 30 - 35℃; Solvent; Temperature; Electrolysis; | 84% |
- 18368-64-4
2-chloro-5-methylpyridine
- 5326-23-8
6-Chloro-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| With oxygen; cobalt(II) acetate In chlorobenzene at 80℃; for 4h; Temperature; | 79.7% |
| With potassium permanganate In water for 5h; Heating; | 60.1% |
| Conditions | Yield |
|---|---|
| With formic acid; 1,3-bis-(diphenylphosphino)propane; nickel(II) acetate tetrahydrate; acetic anhydride In tetrahydrofuran at 100℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; | 60% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide | A n/a B 54.2% |
| A n/a B 53.8% | |
| A n/a B 40.8% |
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
- 10026-13-8, 874483-75-7
phosphorus pentachloride
- 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate
- 5326-23-8
6-Chloro-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| at 120 - 130℃; eintragen des Reaktionsprodukts in Eiswasser; |
- 112091-17-5
3-(1-methylpyrrolidin-2-yl)-6-chloropyridine
- 5326-23-8
6-Chloro-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| (+-)-Py 6-chloro-nicotine; |
- 105827-78-9
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
- 5326-23-8
6-Chloro-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| With potassium permanganate In ethanol for 0.333333h; Oxidation; reflux; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 2: PCl5, POCl3 View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: KMnO4; H2O 2: aqueous HCl View Scheme |
6-Chloronicotinic acid Chemical Properties
Molecular Structure:
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Molecular Formula: C6H4ClNO2
Molecular Weight: 157.5545
IUPAC Name: 6-Chloropyridine-3-carboxylic acid
Synonyms of 6-Chloronicotinic acid (CAS NO.5326-23-8): 6-Chloro-3-pyridinecarboxylic acid ; EINECS 226-201-5 ; NSC 277 ; 3-Pyridinecarboxylic acid, 6-chloro-
CAS NO: 5326-23-8
Product Categories: Nitrogen cyclic compounds ; blocks ; Carboxes ; Pyridines ; Pyridine ; Carboxylic Acids ; Organic acids ; Chloropyridines ; Halopyridines ; Carboxylic Acids ; Picolinic acid series
Melting point: 190 °C
Index of Refraction: 1.59
Molar Refractivity: 36.16 cm3
Molar Volume: 107.1 cm3
Surface Tension: 61 dyne/cm
Density: 1.47 g/cm3
Flash Point: 153.4 °C
Enthalpy of Vaporization: 60.44 kJ/mol
Boiling Point: 330.1 °C at 760 mmHg
Vapour Pressure: 6.84E-05 mmHg at 25°C
6-Chloronicotinic acid Uses
6-Chloronicotinic acid (CAS NO.5326-23-8) is used as building block for different chemical synthesis. Product Data Sheet.
6-Chloronicotinic acid Toxicity Data With Reference
1. RTECS#: CAS# 5326-23-8: None listed
2. LD50/LC50: RTECS: Not available.
3. Carcinogenicity: 6-Chloronicotinic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4. Other: The toxicological properties have not been fully investigated.
6-Chloronicotinic acid Consensus Reports
6-Chloronicotinic acid (CAS NO.5326-23-8) is reported in EPA TSCA Inventory.
6-Chloronicotinic acid Safety Profile
Hazard Codes of 6-Chloronicotinic acid (CAS NO.5326-23-8): 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S24/25: Avoid contact with skin and eyes.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: IRRITANT
HS Code: 29333999
6-Chloronicotinic acid Specification
1、Fire Fighting Measures of 6-Chloronicotinic acid (CAS NO.5326-23-8)
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use WATER spray, dry chemical, CARBON dioxide, or chemical foam.
2、Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.
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