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Cas Database |
| Name |
6-Hydroxynicotinic acid |
EINECS | 225-682-9 |
| CAS No. | 5006-66-6 | Density | 1.451 g/cm3 |
| PSA | 70.16000 | LogP | 0.07310 |
| Solubility | N/A | Melting Point |
300 °C(lit.) |
| Formula | C6H5NO3 | Boiling Point | 384 °C at 760 mmHg |
| Molecular Weight | 139.111 | Flash Point | 186 °C |
| Transport Information | N/A | Appearance | Off-white powder |
| Safety | 26-36-24/25 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
6-Hydroxy-nicotinic acid;1, 6-Dihydro-6-oxo-3-pyridinecarboxylic acid;6-oxo-1H-pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-;Nicotinic acid, 1,6-dihydro-6-oxo-;6-Hydroxy nicotinic acid;6-hydroxy-3-Pyridinecarboxylic acid;2-hydroxy-5-pyridinecarboxlic acid;2-Pyridone-5-carboxylic acid;6-oxo-1H-pyridine-3-carboxylate;Nicotinic acid, 1,6-dihydro-6-oxo- (8CI);6-Hydroxynicotinic acid , 2-Hydroxy-5-pyridinecarboxylic acid; |
Article Data | 34 |
6-Hydroxynicotinic acid Synthetic route
| Conditions | Yield |
|---|---|
| at 35℃; for 45h; Product distribution; production by resting cells of Pseudomonas fluorescens TN5; effects of aeration; optimization of culture medium; effect molybdenum and iron ions and nicotinic acid as inducer on the formation of the hydroxylated enzyme; pH 6.5; | 98.7% |
| With potassium hexacyanoferrate(III) Pseudomonas fluorescens TN-5 immobilized electrochemical reactor,salina solution (0.85percent NaCl); under var. conditions; | |
| With potassium hexacyanoferrate(III) Pseudomonas fluorescens TN-5 immobilized electrochemical reactor, salina solution (0.85percent NaCl); Yield given; |
| Conditions | Yield |
|---|---|
| With potassium hydroxide; acetic anhydride In tetrachloromethane | 79% |
- 2398-81-4
Nicotinic acid N-oxide
- 108-24-7
acetic anhydride
A
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
B
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
| Conditions | Yield |
|---|---|
| for 6h; Heating; | A 1.5% B 5.4% C 62% |
- 2398-81-4
Nicotinic acid N-oxide
A
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
B
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
| Conditions | Yield |
|---|---|
| With acetic anhydride for 6h; Heating; | A 1.5% B 5.4% C 62% |
- 26218-80-4
6-methoxy-nicotinic acid methyl ester
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| With hexamethyldisilathiane; sodium methylate In various solvent(s) at 180℃; for 24h; | 55% |
- 142-08-5
2-Pyridone
- 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
| Conditions | Yield |
|---|---|
| With potassium carbonate at 180 - 200℃; under 15200 Torr; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
- 66572-55-2
6-methoxynicotinic acid
A
- 1628-89-3
2-methoxypyridine
B
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
- 59-67-6
nicotinic acid
A
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
B
- 609-71-2
2-hydroxy-3-carboxypyridine
| Conditions | Yield |
|---|---|
| With potassium hydroxide; fluorine In water at 0℃; for 3.5h; Yield given. Yields of byproduct given; | |
| With potassium hydroxide; fluorine In water at 0℃; Yield given. Yields of byproduct given; | |
| With water; oxygen Quantum yield; Further Variations:; pH-values; Reagents; Irradiation; |
6-Hydroxynicotinic acid Chemical Properties
Molecular Structure of 6-Hydroxynicotinic acid (CAS NO.5006-66-6):
.png)
IUPAC Name: 6-oxo-1H-pyridine-3-carboxylic acid
Empirical Formula: C6H5NO3
Molecular Weight: 139.1088
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 46.61 Å2
Index of Refraction: 1.579
Molar Refractivity: 31.84 cm3
Molar Volume: 95.8 cm3
Surface Tension: 61 dyne/cm
Density: 1.451 g/cm3
Flash Point: 186 °C
Enthalpy of Vaporization: 69.45 kJ/mol
Boiling Point: 384 °C at 760 mmHg
Vapour Pressure: 5.81E-07 mmHg at 25°C
Melting point: >300 °C(lit.)
BRN: 472182
InChI
InChI=1/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3H,(H,7,8)(H,9,10)
Smiles
c1(C(=O)O)cnc(cc1)O
EINECS: 225-682-9
Product Categories: Nitrogen cyclic compounds; blocks; Carboxes; Pyridines; Pyridine; Organic acids
6-Hydroxynicotinic acid Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: Irritant
6-Hydroxynicotinic acid Specification
6-Hydroxynicotinic acid , with CAS number of 5006-66-6, can be called 1,6-dihydro-6-oxo-3-pyridinecarboxylicaci ; 2-Hydroxy-5-pyridinecarboxylic acid ; 2-hydroxypyridine-5-carboxylic acid ; 5-carboxy-2(1h)-pyridinone ; 6-hydroxy-3-pyridinecarboxylic acid ; 6-hydroxynicotinic acid . It is an off-white powder, 6-Hydroxynicotinic acid (CAS NO.5006-66-6) is used as building block in chemical synthesis.
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