CAS No.142-08-5,2-Hydroxypyridine Suppliers,MSDS download

Products Categories

Pharmaceutical (130)
Others (46)
Organic Chemicals (38)
Reagent (6)
Materials (3)
Basic Inorganic Chemicals (1)
Synthetic Flavours & Fragrances (1)
Catalyst and Auxiliary (1)

Basic Information

Molecular Structure:
CAS No.:	142-08-5
Name:	2-Hydroxypyridine
Article Data:	196

Formula:	C₅H₅NO
Molecular Weight:	95.1008
Synonyms:	2(1H)-Pyridone;1H-pyridin-2-one;2-Pyridone;2-Pyridinone;2-Pyridinol;2-Hydroxy pyridine;Pyridin-2(1H)-one;
EINECS:	205-520-3
Density:	1.111 g/cm³
Melting Point:	105-107 °C(lit.)
Boiling Point:	323.7 °C at 760 mmHg
Flash Point:	181.1 °C
Solubility:	Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.
Appearance:	white to light yellow crystal
Hazard Symbols:	Xn,Xi
Risk Codes:	36/37/38-40
Safety:	26-36-37/39-22
Transport Information:	UN 2811
PSA:	33.12000
LogP:	0.78720

Synthetic route

: 13161-30-3
2-hydroxy-pyridine N-oxide

: 142-08-5
2-hydroxypyridin

Conditions

Conditions	Yield
With triphenylphosphine; N-fused tetraphenylporphyrin rhenium(VII) trioxide In dichloromethane at 23℃; for 3h;	99%
With carbon dioxide; water; iron at 100℃; for 10h; Autoclave; Green chemistry; chemoselective reaction;	99%
With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction;	91%

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

: L-threonine, dicyclohexylammonium salt

A: 142-08-5
2-hydroxypyridin

B: 2592-18-9
Boc-Thr-OH

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 8h; Ambient temperature;	A n/a B 98%

...Expand

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

: 147-85-3
L-proline

A: 142-08-5
2-hydroxypyridin

B: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 6h; Ambient temperature;	A n/a B 98%

...Expand

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

: 73-22-3
L-Tryptophan

A: 142-08-5
2-hydroxypyridin

B: 13139-14-5
Boc-Trp-OH

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 4h; Ambient temperature;	A n/a B 98%

...Expand

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

: L-methionine, dicyclohexylammonium salt

A: 142-08-5
2-hydroxypyridin

B: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 7h; Ambient temperature;	A n/a B 96%

...Expand

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

: L-phenylalanine, dicyclohexylammonium salt

A: 142-08-5
2-hydroxypyridin

B: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 12h; Ambient temperature;	A n/a B 96%

...Expand

: 197958-29-5
pyridin-2-ylboronic acid

: 142-08-5
2-hydroxypyridin

Conditions

Conditions	Yield
With hydrazine hydrate; caesium carbonate In water at 80℃; for 12h;	96%

: 40864-08-2
2-benzyloxypyridine

: 142-08-5
2-hydroxypyridin

Conditions

Conditions	Yield
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 1h;	96%
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 3h; Schlenk technique; Irradiation; Inert atmosphere; chemoselective reaction;	95%

: 67-56-1
methanol

: 117-34-0
2,2-diphenylacetic acid

A: 142-08-5
2-hydroxypyridin

B: 3469-00-9
methyl 2,2-diphenylacetate

Conditions

Conditions	Yield
With 2,2'-dipyridyl carbonate; dmap In dichloromethane for 1h; Ambient temperature;	A 90% B 95%

...Expand

: 134-32-7
1-amino-naphthalene

: 96989-50-3
di-2-pyridyl thionocarbonate

A: 142-08-5
2-hydroxypyridin

B: 551-06-4
1-isothiocyanatonaphthalene

Conditions

Conditions	Yield
In dichloromethane for 0.166667h; Ambient temperature;	A n/a B 95%

...Expand

Raw Materials

75-33-2

123-11-5

147-85-3

Downstream Products

Total:178 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 142-08-5

Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The 2-Oxopyridine with CAS registry number of 142-08-5 is also called 2-Hydroxypyridine. The IUPAC name is 1H-pyridin-2-one. Its EINECS registry number is 205-520-3. In addition, the molecular formula is C₅H₅NO and the molecular weight is 95.10. It is a kind of white to light yellow crystal and belongs to the classes of Pyridines; Pyridine; Pyridines derivates; (intermediate of benzoxazole); Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides. And it should be stored in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.58; (2)ACD/LogD (pH 5.5): -0.58; (3)ACD/LogD (pH 7.4): -0.58; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 11.52; (7)ACD/KOC (pH 7.4): 11.52; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Polar Surface Area: 20.31 Å²; (11)Index of Refraction: 1.513; (12)Molar Refractivity: 25.74 cm³; (13)Molar Volume: 85.5 cm³; (14)Polarizability: 10.2 ×10^-24cm³; (15)Surface Tension: 35.7 dyne/cm; (16)Density: 1.111 g/cm³; (17)Flash Point: 181.1 °C; (18)Enthalpy of Vaporization: 56.57 kJ/mol; (19)Boiling Point: 323.7 °C at 760 mmHg; (20)Vapour Pressure: 0.000257 mmHg at 25°C.

Preparation of 2-Oxopyridine: it can be prepared by pyridine 1-oxide. There are some other products, such as pyridin-2-yl-acetonitrile, [2,2']bipyridinyl, pyrrole and pyridine. The yield of this reaction is about 31% at reaction temperature of 750-850 °C.

2-Oxopyridine can be prepared by pyridine 1-oxide

Uses of 2-Oxopyridine: it can be used to get 2-chloro-pyridine. This reaction will need reagents N-chloruccinimide and PPh₃ and solvent dioxane. The reaction time is 4 hours by heating . The yield is about 43%.

2-Oxopyridine can be used to get 2-chloro-pyridine

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. There is limited evidence of a carcinogenic effect. During using it, wear suitable protective clothing, gloves and eye/face protection and do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc[nH]c(=O)c1
(2)InChI: InChI=1/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
(3)InChIKey: UBQKCCHYAOITMY-UHFFFAOYAK

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	410mg/kg (410mg/kg)		Toxicon. Vol. 23, Pg. 815, 1985.
mouse	LD50	intravenous	750mg/kg (750mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 93, Pg. 143, 1953.