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Conditions | Yield |
---|---|
With borane-ammonia complex; C15H30Cl2CoN3P In hexane at 120℃; for 16h; Sealed tube; Inert atmosphere; chemoselective reaction; | 86% |
With hydrogen; sodium methylate; nickel In methanol hydrogen generated in situ electrochemically on Raney nickel electrode; | 72% |
With lithium aluminium tetrahydride | 71% |
Conditions | Yield |
---|---|
With ammonia; hydrogen In methanol at 30℃; for 15h; Autoclave; | 94% |
With ammonium hydroxide; ammonium acetate; hydrogen; [Ru(cod)Cl]2; trisodium tris(3-sulfophenyl)phosphine In toluene at 145℃; under 48754.9 Torr; for 10h; | 47 % Chromat. |
With ammonium hydroxide; hydrogen at 65℃; under 11251.1 Torr; for 12h; Autoclave; Green chemistry; | |
With pyridoxal 5'-phosphate; Amine transaminase 117; rac-methylbenzylamine; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water; dimethyl sulfoxide at 30℃; Reagent/catalyst; Enzymatic reaction; |
pentyl azide
1-pentanamine
Conditions | Yield |
---|---|
With hydrogen; MCM-silylamine Pd(II) In methanol at 20℃; for 2h; Reduction; | 90% |
5-chloro-valeric acid
A
piperidine
B
piperidin-2-one
C
1-pentanamine
D
N-butylamine
Conditions | Yield |
---|---|
Stage #1: 5-chloro-valeric acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry; | A 85% B 9% C 2% D 2% |
Conditions | Yield |
---|---|
With sodium hydroxide; benzyltrimethylazanium tribroman-2-uide In water at 70℃; for 2h; | 80% |
With sodium hydroxide; sodium bromite In water at 75℃; for 0.5h; | 60% |
With sodium hypochlorite |
Conditions | Yield |
---|---|
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia; water In 1,4-dioxane at 135℃; under 5700.38 Torr; for 30h; Inert atmosphere; | A 70.0 %Chromat. B n/a |
N,N'-dipentyl-oxalamide
1-pentanamine
Conditions | Yield |
---|---|
With potassium tert-butylate; hydrogen; [Ru(PtBuNNHBn)H(CO)Cl] In toluene at 135℃; under 30003 Torr; for 24h; | 97 %Spectr. |
valeraldoxime
1-pentanamine
Conditions | Yield |
---|---|
With ethanol; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation; | |
With diethyl ether; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation; | |
With palladium on activated charcoal; acetic acid Hydrogenation; |
Conditions | Yield |
---|---|
With nickel kieselguhr; methyl cyclohexane at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation; | |
With diethyl ether; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation; | |
With ethanol; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation; |
Conditions | Yield |
---|---|
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h; | A 36% B 56% |
With sodium hydroxide; sodium persulfate; copper dichloride In water at 85 - 90℃; for 7h; | A 36% B 56% |
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h; | A 36% B 52% |
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h; | A 36% B 52% |
1. | ipr-rat LDLo:37,500 µg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 31 (1968),238. |