1000025-07-9

Basic information

• Product Name: Vadadustat
• Synonyms: Vadadustat;Vadadustat(AKB-6548/PG-1016548)
• CAS NO: 1000025-07-9
• Molecular Formula: C₁₄H₁₁ClN₂O₄
• Molecular Weight: 306.70114
• Product Categories: API
• Mol File: 1000025-07-9.mol

Chemical Properties

• Boiling Point: 674.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.461±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.09±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Vadadustat(CAS DataBase Reference)
• NIST Chemistry Reference: Vadadustat(1000025-07-9)
• EPA Substance Registry System: Vadadustat(1000025-07-9)

Safety Data

• Hazardous Substances Data: 1000025-07-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Vadadustat is used as an anemia treatment for nondialysis-dependent chronic kidney disease. It functions by stabilizing HIF-1α, which in turn increases erythropoietin levels in the serum, providing an effective treatment for anemia in this patient population.

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Relevant articles and documents

MANUFACTURING PROCESS FOR 3,5-DICHLOROPICOLINONITRILE FOR SYNTHESIS OF VADADUSTAT

Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the syn

Development of a Robust and Scalable Process for the Large-Scale Preparation of Vadadustat

A novel and scalable process is developed for the industrial synthesis of vadadustat. The four-step process is one step shorter compared to the reported routes with an increase in total yield to 49.1%. Detailed optimizations furnish vadadustat with a purity of >99.5% through cross-coupling, aromatic substitution and nitrile hydrolysis, amidation, and ester-ether deprotection. The process is also robust and was demonstrated in a kilogram laboratory. Meanwhile, the corresponding impurity profile was thus studied in detail and well documented.

Preparation method of valduxostat and intermediate thereof

The invention relates to a preparation method of valduxostat and an intermediate thereof, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: taking 3-chloro-5-(3-chlorphenyl)-2-cyanopyridine as a starting material, carrying out hydrolysis reaction, and then carrying out condensation reaction to obtain a compound, namely the intermediate; and further reacting the intermediate compound to obtain vadadustat. The method has the advantages of short route, simple and easily available raw materials, low cost and mild reaction conditions, and is suitable for industrial large-scale production.

NOVEL CRYSTALLINE COMPOUND OF VADADUSTAT

The present invention relates to a novel crystalline compound of Vadadustat, to processes for its preparation, to pharmaceutical compositions containing it and to its use in therapy.

Preparation method of pyridine cyclic compound

The invention provides a preparation method of a pyridine cyclic compound, and belongs to the field of pharmaceutical chemicals. The method comprises the steps: mixing 3,5-dihydroxypicolinic acid, concentrated sulfuric acid and an alcohol solvent, and performing esterification reaction to obtain 3,5-dihydroxypicolinic acid methyl ester; then sequentially carrying out protection group feeding and ammoniation to obtain {[5-(3-chlorphenyl)-3-hydroxypyridin-2-yl]amino}acetic acid. The product produced by the method has the characteristics of high purity, high yield, low cost, simple operation andstable process.

Preparation method and application of phenylpyridine compound

The invention relates to a preparation method and application of a phenylpyridine compound, and belongs to the field of pharmaceutical chemicals. The method disclosed by the invention comprises the following steps: mixing 5-(3-chlorphenyl)-2-cyano-3-chloropyridine, alkali and an organic solvent to obtain 5-(3-chlorphenyl)-3-hydroxyl-pyridine formamide; and then sequentially carrying out a reactionwith sulfuric acid and glycine so as to obtain {[5-(3-chlorphenyl)-3-hydroxypyridine-2-yl] amino} acetic acid. The product produced by the method is high in purity, high in yield, low in process cost, simple to operate and stable in process.

Preparation method and application of picolinamide

The invention provides a preparation method of a picolinamide compound, and belongs to the field of pharmaceutical and chemical industry. According to the preparation method, 3,5-dihydroxypicolinic acid methyl ester, hydroxylamine hydrochloride, an alkali

Preparation method of vadadustat

The invention provides a preparation method of vadadustat, and belongs to the field of pharmaceutical chemical industry. The method comprises the following steps: mixing 3,5-dichloro-2-picolinic acid,methanol and sulfuric acid at a certain temperature, and carrying out a reaction to obtain 3,5-dichloro-2-picolinic acid methyl ester; adding 3-chlorophenylboronic acid, and carrying out a catalyticreaction to obtain 5-(3-chlorphenyl)-3-chloropyridine-methyl formate; and adding glycine into the 5-(3-chlorphenyl)-3-chloropyridine-methyl formate, and carrying out a reaction to obtain the 5-(3-chlorphenyl)-3-chloropyridine-methyl formate. The method has the characteristics of high product purity, high yield, low cost, simple operation and stable process.

Preparation method of vardoxostat intermediate

The invention relates to a preparation method of a vardoxostat intermediate, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: taking 3-methoxy-5-(3-chlorphenyl)-2-cyanopyridine as a starting material, carrying out hydrolysis reaction and condensation reaction to obtain an intermediate of a compound; the intermediate compound can be subjected toa further reaction to obtain vadustat (vardoxostat); the method has the advantages of short route, simple and accessible raw materials, lower cost and mild reaction conditions, and is suitable for industrial large-scale production.

PROCESS FOR PREPARING 2-[[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO]ACETIC ACID

Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.