- Visible-light-driven synthesis of 2-substituted benzothiazoles using CdS nanosphere as heterogenous recyclable catalyst
-
This Letter reports simple, green, and efficient synthesis of mesoporous CdS nanosphere (CdSNS) and its application as heterogeneous catalyst for the synthesis of 2-substituted benzothiazole. We report, for the first time, the synthesis of 2-substituted benzothiazoles from various aryl and alkyl aldehydes under visible light irradiation at room temperature. CdSNS catalyst generated in water demonstrates excellent catalytic activity for both the alkyl and aryl aldehydes, with good recyclability. The reaction yield is high for the electron-donating and electron withdrawing substituents as well as heterocyclic aldehydes with good turn over number (TON) and turnover frequency (TOF).
- Das, Sudipto,Samanta, Suvendu,Maji, Swarup Kumar,Samanta, Partha Kumar,Dutta, Amit Kumar,Srivastava, Divesh N.,Adhikary, Bibhutosh,Biswas, Papu
-
-
Read Online
- Identifying the bond responsible for the fluorescence modulation in an amyloid fibril sensor
-
An ultrafast intramolecular bond twisting process is known to be the responsible mechanism for the sensing activity of the extensively used amyloid fibril sensor thioflavin T (ThT). However, it is not yet known which one of the two possible single bonds in ThT is actually involved in the twisting process. To resolve this fundamental issue, two derivatives of ThT have been designed and synthesized and subsequently their photophysical properties have been studied in different solvents. It is understood from the present study that the rotation around the central C-C single bond, and not that around the C-N single bond, is primarily responsible for the sensor activity of ThT. Detailed viscosity-dependent fluorescence studies revealed that the ThT derivative with restricted C-N bond rotation acts as a better sensor than the derivative with free C-N bond rotation. The better sensory activity is directly correlated with a shorter excited-state lifetime. Results obtained from the photophysical studies of the ThT derivatives have also been supported by the results obtained from quantum chemical calculations.
- Srivastava, Anvita,Singh, Prabhat K.,Kumbhakar, Manoj,Mukherjee, Tulsi,Chattopadyay, Subrata,Pal, Haridas,Nath, Sukhendu
-
-
Read Online
- Metal-organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway
-
Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH2-MIL-125(Ti) MOF surface through electron deficient Ti4+ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.
- Sankar, Velayudham,Karthik, Peramaiah,Neppolian, Bernaurdshaw,Sivakumar, Bitragunta
-
-
Read Online
- Bienzymatic synthesis of benzothia/(oxa)zoles in aqueous medium
-
A series of 2-arylbenzothiazoles and 2-arylbenzoxazoles were synthesized by the reactions of aldehydes and 2-aminothiophenol and 2-hydroxythiophenol, respectively, using glucose oxidase (GOX)-chloroperoxidase (CPO) catalytic system under oxygen atmosphere.
- Kumar, Atul,Sharma, Siddharth,Maurya, Ram Awatar
-
-
Read Online
- Bismuth nitrate as an efficient catalyst for the preparation of 2-arylbenzothiazole derivatives
-
A simple and eco-friendly procedure for synthesis of 2-arylbenzothiazoles in high yields by cyclo-condensation reaction of 2-aminothiophenol and aldehydes in the presence of bismuth nitrate (Bi(NO3)3) as heterogeneous catalyst is des
- Ghashang, Majid
-
-
Read Online
- Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2′-disulfanediyldianiline with aldehydes in water
-
Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2′-disulfanediyldianiline with aldehydes in the presence of sodium dodecyl sulfate in water has been developed. Possible reaction pathways are discussed and the effects of different promoter on the reaction are investigated. The important features of this methodology are simple work-up, environmentally benign, high yields, metal-free, and inexpensive reagents.
- Yang, Xiaoliang,Xu, Yali,Chen, Jiuxi,Ding, Jinchang,Wu, Huayue,Su, Weike
-
-
Read Online
- Sulfamic acid as a recyclable and green catalyst for rapid and highly efficient synthesis of 2-arylbenzothiazoles in water at room temperature
-
2-Arylbenzothiazoles have been synthesized in water in good to excellent yield from direct condensation of various aromatic aldehydes with 2-aminothiophenol promoted by catalytic amount of sulfamic acid at room temperature. This method provides a simple,
- Rostami,Yari
-
-
Read Online
- Camphor sulfonic acid catalyzed a simple, facile, and general method for the synthesis of 2-arylbenzothiazoles, 2-arylbenzimidazoles, and 3H-spiro[benzo[d]thiazole-2,3′-indolin]-2′-ones at room temperature
-
A simple, mild, eco-friendly, general, and convenient approach has been developed for the synthesis of structurally diverse 2-arylbenzothiazole derivatives from the reactions of 2-aminothiophenol and various aromatic aldehydes using camphor sulfonic acid
- Kaur, Gurpreet,Moudgil, Radha,Shamim, Mussarat,Gupta, Vivek Kumar,Banerjee, Bubun
-
-
Read Online
- Epichlorohydrin cross-linked β -cyclodextrin: An environmental method for the synthesis of 2-arylbenzothiazoles derivatives in water
-
In the present study, we report an environmentally benign synthesis of 2-arylbenzothiazoles derivatives from o-aminothiophenol and aldehydes in aqueous medium using β-cyclodextrin polymer as a catalyst and air as an oxidant. The polymer showed excellent c
- El-Remaily, Mahmoud Abd El Aleem Ali Ali,Soliman, Ahmed M. M.
-
-
Read Online
- A simple and eco-friendly process catalyzed by montmorillonite K-10, with air as oxidant, for synthesis of 2-substituted benzothiazoles
-
Simple and eco-friendly synthesis of 2-substituted benzothiazoles is described. The reaction is performed in absolute ethanol at room temperature, using a catalytic amount of montmorillonite K-10, and with continuous bubbling of air as oxidant. Simplicity
- Chen, Guo Feng,Xiao, Nan,Yang, Jing Sen,Li, Hong Yang,Chen, Bao Hua,Han, Li Fen
-
-
Read Online
- Facile one-pot synthesis of 2-arylbenzothiazoles catalyzed by H3PO4/TiO2-ZrO2(1/1) under solvent-free conditions
-
A highly efficient and simple protocol for the preparation of 2-arylbenzothiazoles through condensation of 2-aminothiophenol and different aldehydes in the presence of H3PO4/TiO2-ZrO2(1/1)-cetyl pyridinium bromi
- Naeimi, Hossein,Heidarnezhad, Arash
-
-
Read Online
- Application of N,N′-diiodo-N,N′-1,2-ethandiylbis(p-toluene sulfonamide) as a new reagent for synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles under solvent-free conditions
-
N,N′-Diiodo-N,N′-1,2-ethandiylbis(p-toluene sulfonamide) (NIBTS) is a good and new reagent for synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles at room temperature under solvent-free condition with good to high yield. Absence of solvent, short reaction times, non-corrosive, operational simplicity and environmentally friendliness are the main advantages of this procedure. Copyright
- Veisi, Hojat,Ghorbani-Vaghei, Ramin,Faraji, Alireza,Ozturk, Turan
-
-
Read Online
- Zirconium(IV) oxide chloride and anhydrous copper(II) sulfate mediated synthesis of 2-substituted benzothiazoles
-
A simple, fast and efficient benign procedure has been developed for one-pot synthesis of 2-substituted benzothiazoles in the presence of zirconium(IV) oxide chloride octahydrate (ZrOCl2·8H 2O) and anhydrous copper(II) sulfate. The reaction of 2-aminothiophenol with aldehydes and anhydrides was carried out efficiently in solvent-free conditions with or without microwave irradiation, and adducts were produced in good to excellent yields.
- Moghaddam, Firouz Matloubi,Ismaili, Hossein,Bardajee, Ghasem Rezanejade
-
-
Read Online
- Solid Acid Supported on Magnetic Nanoparticles as a Highly Efficient and Retrievable Catalyst for the Synthesis 2-Substituted Benzothiazoles
-
The use of a recyclable heterogeneous nanomagnetic solid acid catalyst, [Fe3O4@SiO2@(CH2)3NPC–SO3H]Cl, in a simple and highly efficient synthesis of benzothiazole derivatives by the reactio
- Gorjizadeh,Sayyahi
-
-
Read Online
- Piperazinylpyrimidine modified MCM-41 for the ecofriendly synthesis of benzothiazoles by the simple cleavage of disulfide in the presence of molecular O2
-
This is the first report of a sustainable and toxic metal free synthesis of benzothiazoles by the cleavage of ortho-aminothiophenol disulfide using a silica-supported heterogeneous catalyst in water in the presence of molecular O2 as a stoichiometric oxidant. For this purpose a new heterogeneous catalyst (MCM-PP) was synthesized by post synthesis grafting of 2-(piperazin-1-yl)pyrimidine functionalized organosilane onto MCM-41 mesoporous silica and it was characterized by BET surface area analysis, SAXRD, UHR TEM, CHN analysis, 13C CP MAS and 29Si MAS NMR. The reaction requires two different catalytic functions, i.e., an acidic one which is given by MCM-41 and a basic one, given by the organic base moiety anchored to the MCM-41. The greenness of the process was assured as water was exploited as the reaction medium and O2 from air as the stoichiometric oxidant. Furthermore the leaching of the active site can also be avoided as the organic moieties are covalently attached to the inorganic support. Standard leaching experiments proved that the reaction was heterogeneous with this recyclable catalyst.
- Ray, Suman,Das, Paramita,Banerjee, Biplab,Bhaumik, Asim,Mukhopadhyay, Chhanda
-
-
Read Online
- Green and Highly Efficient Synthesis of Mono- and Bis-Benzothiazoles in the Presence of Fe(SD)3 under Ultrasound Irradiation
-
A convenient, practical, green, and environmentally friendly method was developed for the synthesis of benzothiazoles from 2-aminothiophenol and various aldehydes. Bis-benzothiazoles were synthesized in high yield under mild reaction conditions. Products
- Pirbasti, Fateme Ghanbari,Mahmoodi, Nosrat Ollah
-
-
Read Online
- Titanium Tetrabutoxide (TTBO) as Efficient Catalyst for Rapid One Pot Synthesis of 2-Arylbenzothiazoles under Mild Conditions
-
An effective strategy has been developed for rapid and efficient one pot synthesis of 2-arylbenzothiazoles from readily available 2-aminothiophenol and aromatic aldehydes catalyzed by TTBO in high yields and short reaction times. This strategy allows acce
- Naeimi, Hossein,Heidarnezhad, Arash
-
-
Read Online
- A robust one-pot synthesis of benzothiazoles from carboxylic acids including examples with hydroxyl and amino substituents
-
The cyclocondensation of 2-aminothiophenol and carboxylic acids to give benzothiazoles has been carried out under mild conditions using tetrabutylammonium bromide (TBAB) as the reaction medium and triphenyl phosphite as the catalyst. Shorter reaction times, rapid isolation of the products, and excellent yields are advantages of this method. The reaction is found to be general and quite tolerant to the nature of the substituted carboxylic acids.
- Meghdadi, Soraia,Amirnasr, Mehdi,Ford, Peter C.
-
-
Read Online
- A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
-
Heterocyclic aromatic compounds containing an imine (C═N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1H-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was ac
- Maphupha, Mudzuli,Juma, Wanyama P.,De Koning, Charles B.,Brady, Dean
-
-
Read Online
- Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water
-
A series of 2-substituted benzothiazoles have been synthesized by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl) in the presence of a catalytic amount of cetyltrimethyl ammonium bromide (CTAB) "on wa
- Yang, Xiao-Liang,Xu, Chun-Mei,Lin, Shao-Miao,Chen, Jiu-Xi,Ding, Jin-Chang,Wu, Hua-Yue,Sua, Wei-Ke
-
-
Read Online
- Synthesis and photophysical properties of yellow-emitting iridium complexes. Effect of the temperature on the character of triplet emission
-
The parent study includes synthesis end photophysical characterization of four new phosphorescent cyclometalated iridium (III) complexes. The cyclometaled ligands used here are 2-(4-chlorophenyl)benzo[d]thiazole, 2(4isopropylphenyl) benzo[d] thiazole, 2-(
- Ivanov,Stanimirov,Kaloyanova,Petkov
-
-
Read Online
- One-step synthesis of 2-arylbenzothiazole ('BTA') and -benzoxazole precursors for in vivo imaging of β-amyloid plaques
-
We report the simple and efficient synthesis of 2-arylbenzothiazoles ('BTA') and 2-arylbenzoxazoles by direct coupling of benzothiazoles or benzoxazoles with aryl bromides. This method permits direct one-step access to precursors of radiolabeled BTA-1 and
- Alagille, David,Baldwin, Ronald M.,Tamagnan, Gilles D.
-
-
Read Online
- Rare-earth metal chlorides as efficient catalysts for the simple and green synthesis of 1,2-disubstituted benzimidazoles and 2-substituted benzothiazoles under ultrasound irradiation
-
Under solvent-free and ultrasonic irradiation conditions, efficient methods for the synthesis of 1,2-disubstitued benzimidazoles and 2-substitued benzothiazoles by employing rare-earth metal chlorides as catalysts are described. The methods have the advan
- Zhang, Li-Jun.,Xia, Jing,Zhou, Yong-Qing,Wang, Hua,Wang, Shao-Wu.
-
-
Read Online
- Efficient synthesis of 2-arylbenzothiazole derivatives with the aid of a low-valent titanium reagent
-
A novel and facile synthesis of 2-arylbenzothiazole derivatives was accomplished in good yields via the novel reductive cyclization of bis-(2-benzalaminophenyl)disulfide promoted by the TiCl4/Sm system. The advantages of this new method are the easily accessible starting materials, short reaction time, and moderate to good yields. Copyrigh
- Shi, Da-Qing,Rong, Shao-Feng,Dou, Guo-Lan
-
-
Read Online
- Water-promoted dowex 50W catalyzed highly efficient green protocol for 2-arylbenzothiazole formation
-
2-Aminothiophenol and a variety of aryl aldehydes were allowed to react in one-pot operation to give 2-aryl-benzothiazoles in excellent yields in the presence of Dowex 50W in water. Very high yields coupled with the ease of work-up procedure, formation of no side products, employment of "reusable" catalyst, and "green" synthesis in aqueous medium without maintaining anhydrous reaction conditions are the most important aspects of this methodology.
- Mukhopadhyay, Chhanda,Datta, Arup
-
-
Read Online
- An efficient synthesis of 2-arylbenzothiazoles using silica sulfuric acid, oxalic acid and aluminum chloride hydrate as heterogeneous and homogeneous catalyst systems
-
A convenient method for the synthesis of 2-arylbenzothiazoles from condensation of aromatic/heteroaromatic aldehydes with 2-aminothiophenol has been developed using inexpensive, green and reusable solid acids - silica sulfuric acid (SSA), oxalic acid or A
- Maleki, Behrooz
-
-
Read Online
- Role of graphene oxide as a heterogeneous acid catalyst and benign oxidant for synthesis of benzimidazoles and benzothiazoles
-
We report the synthesis of benzothiazoles and benzimidazoles using graphene oxide as an effective catalyst with good yields and easy recyclability. Graphene oxide plays the dual role of a metal-free acid catalyst and an oxidizing agent. The mechanism of a
- Dhopte, Kiran B.,Zambare, Rahul S.,Patwardhan, Anand V.,Nemade, Parag R.
-
-
Read Online
- An efficient synthesis of 2-substituted benzothiazoles in the presence of FeCl3/Montmorillonite K-10 under ultrasound irradiation
-
2-Substituted benzothiazoles have been synthesized via one-pot reaction from aromatic aldehydes and o-aminothiophenol in the presence of FeCl 3/Montmorillonite K-10 in absolute methanol at 25-30°C under ultrasound irradiation. The remarkable ad
- Chen, Guo-Feng,Jia, Hui-Ming,Zhang, Li-Yan,Chen, Bao-Hua,Li, Ji-Tai
-
-
Read Online
- A novel method for the synthesis of benzothiazole heterocycles catalyzed by a copper-DiAmSar complex loaded on SBA-15 in aqueous media
-
Cu(ii)-DiAmSar complex functionalized mesoporous SBA-15 silica support was employed for the synthesis of benzothiazole heterocycles in aqueous media as a green solvent with excellent yields. The resulting novel catalyst is extraordinarily stable and inhib
- Mohammadi, Marzieh,Bardajee, Ghasem Rezanejade,Pesyan, Nader Noroozi
-
-
Read Online
- Synthesis of 2-arylbenzothiazoles using nano BF3/SiO2 as a reusable and efficient heterogeneous catalyst under mild conditions
-
2-Arylbenzothiazoles were synthesized via condensation of 2-aminothiophenol and different aldehydes catalyzed by nano silica-supported boron trifluoride (nano BF3/SiO2) as an efficient and reusable catalyst in high yields and short r
- Naeimi, Hossein,Heidarnezhad, Arash
-
-
Read Online
- Bakers' yeast catalyzed synthesis of benzothiazoles in an organic medium
-
The cyclocondensation of 2-aminothiophenol and aldehydes has been carried out in dichloromethane using bakers' yeast as a catalyst for obtaining 2-aryl/heteryl benzothiazoles in good yields.
- Pratap, Umesh R.,Mali, Jyotirling R.,Jawale, Dhanaji V.,Mane, Ramrao A.
-
-
Read Online
- Use of NaOH as a new activator for the palladium-catalyzed direct CH arylation of thiazole derivatives
-
Sodium hydroxide is found to serve as a new activator for the palladium-catalyzed C-H arylation of thiazole derivatives with aryl bromides and aryl iodides. The reaction of benzothiazole proceeds smoothly with 4-bromoanisole to afford the corresponding coupling product in an excellent yield.
- Miyaoku, Takayuki,Mori, Atsunori
-
-
Read Online
- Reusable proline-based ionic liquid catalyst for the simple synthesis of 2-arylbenzothiazoles in a biomass medium
-
A simple, efficient, and eco-friendly aerobic procedure for synthesis of 2-substituted benzothiazoles catalyzed by facile prepared [N2222][Pro] in a biomass medium (ethyl lactate) has been developed. The reactions afford the target 2-arylbenzot
- Yu, Zhi-Yu,Fang, Qiu-Sheng,Zhou, Jia,Song, Zhi-Bin
-
-
Read Online
- Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity
-
To investigate one possible mechanism of action of the cytotoxic activity of benzothiazoles, we synthesized 2-(substituted-phenyl)benzothiazoles and evaluated their ability to inhibit topoisomerase II activities. Solid phase combinatorial method using tri
- Choi, Suk-June,Park, Hyen Joo,Lee, Sang Kook,Kim, Sang Woong,Han, Gyoonhee,Choo, Hea-Young Park
-
-
Read Online
- An efficient procedure for the synthesis of benzoxazole and benzothiazole derivatives using a H2O2/SiO2-FeCl3 system
-
A series of benzoxazole and benzothiazoles was readily prepared from the reaction of ortho-aminophenol/ortho-aminothiophenol and aldehydes using solid silica supported ferric chloride (SiO2-FeCl3) as catalyst followed by oxidation with H2O2 under ambient conditions. Some of advantages of this method are a simple and convenient procedure, easy purification, and shorter reaction times. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
- Mosslemin, Mohammad Hossein,Fazlinia, Abbas
-
-
Read Online
- Magnetically separable nano CeO2: A highly efficient catalyst for ligand free direct C-H arylation of heterocycles
-
An efficient, ligand free, nano CeO2-Fe3O4 catalyzed direct C-H arylation of heteroarenes such as benzoxazole and benzothiazole has been carried out with aryl halides in DMSO or arenediazonium salts in water. The catalyst exhibited high activity with moderate to excellent product yields under mild reaction conditions. Nano CeO2-Fe3O4 was synthesized and characterized by SEM, TEM, EDAX, XRD, FTIR, DSC-TGA, and ICP-MS analyses. The catalytic activity and stability of the catalyst were excellent, even after the ten cycle of recyclability
- Shelkar, Radheshyam S.,Balsane, Kishor E.,Nagarkar, Jayashree M.
-
-
Read Online
- Efficient 2,4,6-trichloro-1,3,5-triazine-catalyzed synthesis of 2-arylbenzothiazoles and bisbenzothiazoles by condensation of 2-aminithiophenol with aldehydes under mild conditions
-
2,4,6-Trichloro-1,3,5-triazine efficiently catalyzed the condensation reactions between 2-aminothiophenol and aromatic aldehydes to afford 2-arylbenzothiazolles in good-to-excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst
- Maleki, Behrooz,Azarifar, Davood,Hojati, Seyede Fateme,Veisi, Hojat,Gholizadeh, Mostafa,Salehabadi, Hafezeh,Moghadam, Mona Khodaverdian
-
-
Read Online
- Pd(OAc)2 catalyzed synthesis of 2-aryl- and 2-heteroaryl- benzoxazoles and benzothiazoles in imidazolium ionic liquids (ILs) without additives and with recycling/reuse of the IL
-
A facile, high yielding, method for the synthesis of a library of 2-aryl- and 2-heteroaryl-benzoxazoles and benzothiazoles from readily available Schiff bases is reported employing catalytic amounts of Pd(OAc)2 in imidazolium ionic liquids (bmim)BF4 and (bmim)PF6 without ligands and/or additives. Simple product isolation and recycling/re-use of the IL are additional advantages of this method.
- Kalkhambkar, Rajesh G.,Laali, Kenneth K.
-
-
Read Online
- Novel synthesis of 2-arylbenzothiazoles
-
A new method for the synthesis of 2-arylbenzothiazoles by the reaction of dibenzyl disulfides with o-aminothiophenol is suggested. A possible mechanism of the new transformation is discussed. 2-Phenylbenzothiazole can also be prepared by reactions of o-aminothiophenol with benzyl mercaptane or sodium benzyl thiosulfate.
- Shirinian,Melkova,Belen'kii,Krayushkin
-
-
Read Online
- Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking
-
Benzothiazole derivatives 1-26 have been synthesized and their in vitro β-glucuronidase potential has been evaluated. Compounds 4 (IC50 = 8.9 ± 0.25 μM), 5 (IC50 = 36.1 ± 1.80 μM), 8 (IC50 = 8.9 ± 0.38 μM), 13 (IC50/
- Khan, Khalid Mohammed,Rahim, Fazal,Halim, Sobia Ahsan,Taha, Muhammad,Khan, Momin,Perveen, Shahnaz,Zaheer-Ul-Haq,Mesaik, Muhammad Ahmed,Iqbal Choudhary
-
-
Read Online
- Efficient synthesis of benzothiazole derivatives by reaction of bis(2-aminophenyl) disulfides with aldehydes mediated by NaSH under microwave irradiation
-
2-Substituted benzothiazoles were synthesized through condensation of bis(2-aminophenyl) disulfides with arylaldehydes catalyzed by inexpensive NaSH in PEG-300 and assisted by low energy microwave irradiation(25?W). Various 2-substitutedbenzothiazoles were obtained in moderate to high yields after simple post-reaction processing including adding distilled water, filtrating, and drying. Moreover, it was found that the S-S bond of the disulfide was reduced by NaSH and also by the intermediate benzothiazoline.
- Liu, Lei,Zhang, Fa,Wang, Hongliang,Zhu, Ning,Liu, Bo,Hong, Hailong,Han, Limin
-
-
Read Online
- Copper-catalyzed synthesis of substituted benzothiazoles via condensation of 2-aminobenzenethiols with nitriles
-
An efficient and convenient method was developed for the formation of 2-substituted benzothiazoles via a copper-catalyzed condensation of 2-aminobenzenethiols with nitriles. The developed method is applicable to a wide range of nitriles containing different functional groups furnishing excellent yields of the corresponding products.
- Sun, Yadong,Jiang, Huanfeng,Wu, Wanqing,Zeng, Wei,Wu, Xia
-
-
Read Online
- Synergism in semiconducting nanocomposites: Visible light photocatalysis towards the formation of C-S and C-N bonds
-
A simple, facile and visible light driven photochemical synthesis of 2-substituted benzothiazoles and 2-substituted benzimidazoles is achieved with CdSe nanocomposites as a photocatalyst. These nanocomposites are prepared by the molecular self assembly of 2-3 nm sized zinc blende CdSe phase within the layers of montmorillonite (MMT) through intercalation forming lamellar structure. CdSe/MMT exhibits excellent photocatalytic activity towards the synthesis of benzazoles using aliphatic, aromatic and heterocyclic aldehydes with better yields, and the efficiency is retained up to five cycles. XRD, XPS and Raman analyses of fresh and used CdSe/MMT reveal the passivation of structural defects due to the formation of a thin layer of CdO on the photocatalyst surface. The mixed phase of CdSe-CdO facilitates the generation of a hetero-junction on the CdSe/MMT surface, which is beneficial for photostability and sustainability. This process is also efficient under solar light and provides easy product isolation on the gram scale. Thus, it may be regarded as a greener methodology for the synthesis of bioactive scaffolds with excellent yields and high chemoselectivity using a tailor-made photocatalyst.
- Wade, Anil R.,Pawar, Hari R.,Biware, Megha V.,Chikate, Rajeev C.
-
-
Read Online
- Synthesis and in vitro characterization of some benzothiazole- and benzofuranone-derivatives for quantification of fibrillar aggregates and inhibition of amyloid-mediated peroxidase activity
-
Neurodegenerative diseases are characterized by amyloid deposition. Thioflavin T (ThT) is one of the molecules considered for detection of amyloid deposits; however, its lipophilicity is too low to cross the blood-brain barrier. Therefore, there is a strong motivation to develop suitable compounds for in vitro fibril quantification as well as for in vivo amyloid imaging. Moreover, oxidative stress (particularly, uncontrolled peroxidase activity) has frequently been reported to play a critical role in the onset/progression of some neurodegenerative disorders. In this study, we describe the synthesis of some benzothiazole and benzofuranone compounds and examine their peroxidase inhibitory properties. Furthermore, to establish the potential binding of synthesized compounds to amyloid aggregates, their in vitro binding to some non-disease related amyloidogenic proteins were characterized. Analyses of the in vitro binding studies indicated that compounds 2 and 4 bind to the amyloid structures successfully while compounds 1 and 3 showed a low affinity in binding to fibrils. Furthermore, compounds 3 and 4 were observed to inhibit amyloid-mediated peroxidase activity in a reversible un-competitive manner.
- Ghadami, Seyyed Abolghasem,Hossein-Pour, Zahra,Khodarahmi, Reza,Ghobadi, Sirous,Adibi, Hadi
-
-
Read Online
- Lithium bromide catalyzed efficient and convenient synthesis of 2-arylbenzothiazole derivatives
-
A new and efficient protocol was developed for synthesis of benzothiazoles using lithium bromide as catalyst under environmentally friendly conditions. The developed synthetic protocol represents a novel and very simple route for preparation of 2-substitu
- Gill, Charansingh H.,Nikam, Mukesh D.,Mahajan, Pravin S.,Chate, Asha V.,Dabhade, Sanjay K.,Badadhe, Pravin V.
-
-
Read Online
- Copper supported on functionalized MCM-41 as a novel and a powerful heterogeneous nanocatalyst for the synthesis of benzothiazoles
-
A new functionalized mesoporous catalyst (Cu(II)-Glycerol/MCM-41) has been synthesized as a highly efficient heterogeneous nanocatalyst for the synthesis of benzothiazoles derivatives. Powder XRD, TGA, TEM, SEM, EDX, BET, FT-IR and ICP-OES techniques are
- Noroozi Pesyan, Nader,Batmani, Hana,Havasi, Forugh
-
-
Read Online
- Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by silica sulfuric acid
-
2-Substituted benzothiazoles have been synthesized via one-pot reaction from aromatic aldehydes and o-aminothiophenol catalyzed by silica sulfuric acid in absolute methanol at room temperature. The remarkable advantages offered by this method are an envir
- Chen, Guo Feng,Zhang, Li Yan,Jia, Hui Ming,Chen, Bao Hua,Li, Ji Tai,Wang, Shu Xiang,Bai, Guo Yi
-
-
Read Online
- Na2S2O4-mediated cyclocondensations of 2,2′-disulfanediyldi- anilines with aldehydes: A facile and inexpensive method for the synthesis of 2-substituted benzothiazoles
-
A facile and inexpensive method for the synthesis of 2-substituted benzothiazoles has been developed by Na2S2O 4-mediated cyclocondensations of 2,2′-disulfanediyldianilines with aldehydes. In the presence of Na2S2O4 and 4 A molecular sieves, a variety of 2-substituted benzothiazoles were obtained from the reaction of 2,2′-disulfanediyldianilines with aldehydes in moderate to high yields. Copyright
- Wang, Zhanglin,Tang, Riyuan,Xiao, Qin
-
-
Read Online
- Copper(II)-diaminosarcophagine-functionalized SBA-15: A heterogeneous nanocatalyst for the synthesis of benzimidazole, benzoxazole and benzothiazole derivatives under solvent-free conditions
-
Solvent-free organic reactions were studied over periodic mesoporous silica (SBA-15) containing a Cu(II) organometallic complex. This heterogeneous catalyst was achieved by coordination of Cu(II) ions with the diaminosarcophagine ligand and then its grafting onto the surface of SBA-15. This catalyst displayed ordered mesoporous channels, which implies an extremely high dispersion of the Cu(II) complex and the convenient diffusion of reactant molecules into the pore channels. Therefore, this catalyst can offer high activity and also facile separation or recycling when compared with its homogeneous counterparts.
- Bardajee, Ghasem Rezanejade,Mohammadi, Marzieh,Kakavand, Nahale
-
-
Read Online
- Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions
-
Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0-catalyzed cross-coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi-step transformations. Here we introduce base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones. We show that under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.
- Blakemore, David C.,Cook, Xinlan A. F.,Moses, Ian B.,Pantaine, Lo?c R. E.,Sach, Neal W.,Shavnya, Andre,Willis, Michael C.
-
p. 22461 - 22468
(2021/09/09)
-
- ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles
-
The synthesis of 2-substituted benzothiazoles has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process.
- Dhawale, Kiran D.,Ingale, Ajit P.,Shinde, Sandeep V.,Thorat, Nitin M.,Patil, Limbraj R.
-
p. 1588 - 1601
(2021/03/18)
-
- Ultrasound-assisted efficient and green synthesis of 2-substituted benzothiazoles under solvent-free condition using recyclable sulfated tungstate
-
Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the synthesis of 2-substituted benzothiazoles. The corresponding benzothiazoles were obtained using a condensation reaction of 2-aminothiophenol with various aldehydes under ultrasound irradiation at room temperature. Various functional groups on the 2-aminothiophenol as well as on the aldehydes were tolerated to provide 2-substituted benzothiazoles derivatives in excellent yields. The faster reaction rate, solvent-free or mild reaction conditions, wide functional group compatibility, excellent yields, easy work-up procedure, and excellent catalyst recyclability are the advantages of this protocol. These advantages make this process more practicable, cost-effective, and environmentally benign.
- Pise, Ashok S.,Ingale, Ajit P.,Dalvi, Navnath R.
-
supporting information
p. 3629 - 3641
(2021/10/12)
-
- Ionic liquid-immobilized hybrid nanomaterial: an efficient catalyst in the synthesis of benzimidazoles and benzothiazoles via anomeric-based oxidation
-
Abstract: In this study, a novel ionic liquid immobilized on silica-coated cobalt-ferrite magnetic nanoparticles. This novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was characterized by various microscopic and spectroscopic techniques including Fourier transformation infrared spectroscopy (FT–IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (SEM), the electron-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA/DTG). The catalytic activity of prepared nanomaterial was considered in the synthesis of the benzothiazole and benzimidazole derivatives. This method has several advantages such as good to excellent yields, short reaction times, solvent-free and environmentally-benign conditions, and simple work-up. Besides, nanocatalyst can be easily separated from the reaction mixture with the external magnetic field and reused several times without any loss of its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].
- Bodaghifard, Mohammad Ali,Shafi, Saeideh
-
p. 677 - 687
(2020/09/18)
-
- Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach
-
In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.
- Datta, Arup
-
-
- Fast and high-efficiency synthesis of 2-substituted benzothiazoles via combining enzyme catalysis and photoredox catalysis in one-pot
-
An efficient and green method, combining enzymatic and visible-light catalysis for synthesis of the widely applicable 2-substituted benzothiazoles, has been developed. This method features a relay catalysis protocol consisting of biocatalytic promiscuity
- Yang, Zeng-Jie,Gong, Qing-Tian,Yu, Yuan,Lu, Wei-Fan,Wu, Zhe-Ning,Wang, Na,Yu, Xiao-Qi
-
supporting information
(2021/01/14)
-
- Synthesis of 2-aryl-benzothiazoles via Ni-catalyzed coupling of benzothiazoles and aryl sulfamates
-
2-Aryl-benzothiazoles have been successfully synthesized via a simple coupling reaction between benzothiazoles and aryl sulfamates using a nickel catalyst. The nickel catalyst is inexpensive, reusable and commercially available. In addition, the use of highly expensive palladium catalysts and unstable raw materials has been avoided. 2-Aryl-benzothiazoles bearing various substituents on the aryl groups were obtained in good yield.
- Gou, Liping,Song, Renyuan,Wang, Guangrong,Yu, Xiaofeng,Zhang, Zhen
-
-
- Sulfamic acid-catalyzed conversion of o-aminothiophenol and aromatic aldehydes to 2-arylbenzothiazoles
-
Non-metallic, non-toxic, and cheap sulfamic acid was used as a catalyst for the synthesis of 2-arylbenzothiazole from o-aminothiophenol and aromatic aldehydes bearing electron-donating or electron-withdrawing groups. The sulfamic acid catalyst can be reus
- Shi, Chunjie,Song, Renyuan,Wang, Guangrong,Yu, Xiaofeng
-
p. 871 - 879
(2020/09/09)
-
- "Metal-Free" Nanoassemblies of AIEE-ICT-Active Pyrazine Derivative: Efficient Photoredox System for the Synthesis of Benzimidazoles
-
Supramolecular nanoassemblies of an AIEE-ICT-active pyrazine derivative (TETPY) having strong absorption in the visible region and excellent transportability have been utilized as an efficient photoredox catalytic system for the synthesis of a variety of benzimidazoles having electron-withdrawing/electron-releasing/aliphatic groups under "metal-free"conditions. The reaction protocol involves the successful harvesting of visible light by TETPY assemblies to catalyze the coupling of o-phenylenediamine/substituted diamines and substituted aromatic/heterocyclic/aliphatic aldehydes under aerial conditions using mixed aqueous media as the reaction solvent. TETPY assemblies could activate aerial oxygen to generate superoxide for completing the vital proton abstraction step without the need for any external metal/base/oxidant. Moreover, all the products are purified by recrystallization from organic solvents. The TETPY assemblies also exhibited high efficiency in catalyzing the synthesis of 2-substituted benzothiazoles and quinazolines in excellent yields.
- Dadwal, Shruti,Kumar, Manoj,Bhalla, Vandana
-
p. 13906 - 13919
(2020/11/20)
-
- Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions
-
The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.
- Abdelrasoul, Amira,Ghorashi, Nadia,Moradi, Reza,Rostami, Amin,Shokri, Zahra
-
p. 14254 - 14261
(2020/04/23)
-
- Synthesis, characterization, and applications of novel Co(II)-pyridoxal phosphate-Schiff base/SBA-15 as a nanocatalyst for the green synthesis of benzothiazole heterocycles
-
Mesoporous heterogeneous santa barbara amorphous (SBA)-15-supported cobalt complex, as a novel nanocatalyst containing N–O chelating Schiff-base ligand was successfully synthesized by the reaction of SBA-15 and Cobalt(II)-Schiff-base complex. The Co(II)-S
- Yari, Hassan,Dehkharghani, Rahebeh A.,Bardajee, Ghasem R.,Akbarzadeh-T, Niloufar
-
p. 1490 - 1500
(2020/03/30)
-
- TBHP/KI-Promoted Annulation of Anilines, Ethers, and Elemental Sulfur: Access to 2-Aryl-, 2-Heteroaryl-, or 2-Alkyl-Substituted Benzothiazoles
-
An efficient TBHP/KI-promoted annulation of anilines with ethers and elemental sulfur has been developed through the selective C-O bond cleavage of ethers under transition-metal-free conditions. A wide range of 2-aryl-, 2-heteroaryl-, and 2-alkyl-substituted benzothiazoles were easily prepared with satisfactory yields and good functional group compatibility.
- Zhang, Jie,Zhao, Xin,Liu, Ping,Sun, Peipei
-
p. 12596 - 12605
(2019/10/11)
-
- A novel ternary GO@SiO2-HPW nanocomposite as an efficient heterogeneous catalyst for the synthesis of benzazoles in aqueous media
-
A new solid acid catalyst, consisting of 12-phosphotungstic heteropoly acid (HPW) supported on graphene oxide/silica nanocomposite (GO@SiO2), has been developed via immobilizing HPW onto an amine-functionalized GO/SiO2 surface through coordination interaction (GO@SiO2-HPW). The GO@SiO2-HPW nanocomposite was characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD). The prepared nanocomposite could be dispersed homogeneously in water and further used as a heterogeneous, reusable, and efficient catalyst for the synthesis of benzimidazoles and benzothiazoles by the reaction of 1,2-phenelynediamine or 2-aminothiophenol with different aldehydes.
- Habibzadeh, Setareh,Firouzzadeh Pasha, Ghasem,Tajbakhsh, Mahmood,Amiri Andi, Nasim,Alaee, Ehsan
-
p. 934 - 944
(2019/06/13)
-
- Silica-supported zinc chloride (ZnCl2/SiO2)-induced efficient protocol for the synthesis of N-sulfonyl imines and 2-Arylbenzothiazole
-
A straightforward strategy for the synthesis of N-sulfonyl imine derivatives from sulfonamides and aryl aldehydes utilizing Silica-supported zinc chloride (ZnCl2/SiO2, silzic) as a catalyst under solvent-free conditions has been developed. 2-Arylbenzothiazole derivatives were also synthesized by the reaction of 2-aminothiophenol with aryl aldehydes under the same conditions. This procedure has advantages of high yields, mild reaction condition, simple procedure, low cost, and simplicity of workup. The catalyst has the same efficiency on its reuse up to three times.
- Soliman, Hanan A.,El-Shahat, Mahmoud,Soliman, Abdel-Ghany
-
p. 584 - 591
(2019/07/31)
-
- Catalyst-free synthesis of benzimidazole and benzothiazole derivatives by the cleavage of the C–C double bond of 5-arylidenepyrimidine-2,4,6-(1H,3H,5H)-triones
-
Background: Benzimidazole and benzothiazole subunits exist in many biologically active molecules, natural products, and synthetic compounds. These compounds have recently gained widespread interest due to their key role in medically important compounds, such as those exhibiting anticancer activity, antimicrobial activity, inhibition of hepatitis C virus NS5B polymerase, p38 kinase inhibitory activity, and anti-inflammatory activity. Methods: 2-Substituted benzimidazole and benzothiazole derivatives have been synthesized by the condensation of 1,2-phenylenediamine or 2-aminobenzothiophenol with 5-arylidenepyrimidine-2,4,6-(1H,3H, 5H)-trione derivatives via cleavage of C-C double bond without using a catalyst in EtOH under reflux conditions. Results: We report here a very simple, novel, efficient, and catalyst-free method for the synthesis of benzimidazole and benzothiazole in good to excellent yields from the treatment of 1,2-phenylenediamine and 2-aminothiophenol with various 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-trione, respectively. This reaction proceeds via cleavage of a C=C double bond and elimination of barbituric acid. Conclusion: This method appears to be general for the synthesis of benzimidazoles and benzothiazoles using 5-arylidenepyrimidine-2,4,6-(1H,3H,5H)-trione derivatives containing various aromatic and heteroaromatic aldehydes such as furfural and thiophene-2-carbaldehyde with electron-withdrawing and electron-releasing groups.
- Darehkordi, Ali,Ramezani, Mahin,Rahmani, Fariba,Poor, Mahboobe Amirani
-
p. 290 - 294
(2018/04/20)
-
- Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones
-
Selective construction of 2-substituted benzothiazoles from o-iodoaniline derivatives S8 and N-tosylhydrazone via a copper-promoted [3 + 1 + 1]-type cyclization reaction has been realized. In the protocol, the carbon atom on N-tosylhydrazone could be regulated to construct benzothiazole by changing the reaction system. Furthermore, the transformation has achieved the construction of multiple carbon-heteroatom bonds.
- Huang, Yubing,Zhou, Peiqi,Wu, Wanqing,Jiang, Huanfeng
-
p. 2460 - 2466
(2018/02/23)
-
- Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents
-
Cross-coupling of (hetero)arylthiols with arylzinc reagents via C-S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg2+ and Li+ ions were demonstrated to facilitate the reaction.
- Yang, Bo,Wang, Zhong-Xia
-
p. 6220 - 6223
(2017/11/24)
-
- NaY Zeolite Functionalized by Sulfamic Acid/Cu(OAc)2 as a Novel and Reusable Heterogeneous Hybrid Catalyst in Efficient Synthesis of Bis, Tris, and Tetrakis(indolyl)methanes, 3,4-Dihydropyrimidin-2(1H)-ones, and 2-Aryl-1H-benzothiazoles
-
An efficient acid-catalyzed synthesis of some bis, tris, and tetrakis(indolyl)methanes, 3,4-dihydropyrimidin-2(1H)-ones, and 2-aryl-1H-benzothiazoles is reported using NaY zeolite functionalized by sulfamic acid/Cu(OAc)2 (NaY zeolite-NHSO3
- Kazemi, Samira,Mobinikhaledi, Akbar,Zendehdel, Mojgan
-
p. 764 - 776
(2017/07/25)
-
- Magnetic Co-doped NiFe2O4 Nanocomposite: A Heterogeneous and Recyclable Catalyst for the One-Pot Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles under Solvent-Free Conditions
-
A simple and efficient procedure for the synthesis of benzimidazoles, benzoxazoles, and benzothiazoles via the condensation of o-phenylenediamine, o-aminophenol, and o-aminothiophenol with various benzaldehydes by using magnetic Co-doped NiFe2O4 nanoparticles has been developed. This nanocatalyst has advantages such as excellent product yields, solvent-free conditions, and very short reaction times. After any experiment, the magnetic nanocatalyst could be easily separated with the aid of an external magnet and reused at least four times without any loss of its catalytic performance.
- Karimian, Azam,Mohammadzadeh Kakhki, Roya,Kargar Beidokhti, Hamideh
-
p. 1316 - 1325
(2017/11/22)
-
- Antidiabetic potential and enzyme kinetics of benzothiazole derivatives and their non-bonded interactions with α-glucosidase and α-amylase
-
Benzothiazole derivatives were synthesized and their antidiabetic potential evaluated using α-glucosidase, α-amylase, non-enzymatic glycosylation of hemoglobin and advanced glycation end product inhibition assays. Compound 3l showed low IC50 va
- Puranik, Ninad V.,Puntambekar, Hemalata M.,Srivastava, Pratibha
-
p. 805 - 816
(2016/03/08)
-
- The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies
-
Benzothiazole and its natural or synthetic derivatives have been used as precursors for several pharmacological agents for neuroprotective, anti-bacterial, and anti-allergic activities. The objecctive of the present study was to evaluate effects of benzot
- Khan, Khalid Mohammed,Mesaik, Mohammad A.,Abdalla, Omer M.,Rahim, Fazal,Soomro, Samreen,Halim, Sobia A.,Mustafa, Ghulam,Ambreen, Nida,Khalid, Ahmad Shukralla,Taha, Muhammad,Perveen, Shahnaz,Alam, Muhammad Tanveer,Hameed, Abdul,Ul-Haq, Zaheer,Ullah, Hayat,Rehman, Zia Ur,Siddiqui, Rafat Ali,Voelter, Wolfgang
-
-
- Synthesis of 2-substituted benzimidazoles and benzothiazoles using Ag2CO3/Celite as an efficient solid catalyst
-
An efficient and simple approach for the synthesis of 2-substituted benzimidazoles and benzothiazoles through a coupling of 1,2-phenylenediamines and 2-aminothiophenols with variety of aryl aldehydes in ethanol at 70 °C using Ag2CO3/Celite as solid catalyst is described. The procedure features short reaction time, excellent yields and simple workup.
- Soleimani, Ebrahim,Khodaei, Mohammad Mehdi,Yazdani, Hossein,Saei, Parisa,Zavar Reza, Javad
-
p. 1281 - 1285
(2015/06/02)
-
- Synthesis, crystal structure, photophysical properties and theoretical study of a new iridium(III) complex containing 2-phenylbenzothiazole ligand
-
A new bis-cyclometalated iridium(III) complex [Ir(dmabt)2 (bipy)[PF6](3) (dmabt = 4-(benzo[d]thiazol-2-yl)-N,N-dimethylaniline, bipy = 2,2′-bipyridine) has been synthesized and fully characterized. The structure of complex 3 has been
- Zeng, Yong-Pi,Gao, Cheng-Wei,Hu, Liang-Jiang,Chen, Hao-Hua,Chen, Guang-Ying,Li, Gao-Nan,Niu, Zhi-Gang
-
p. 917 - 922
(2016/01/20)
-
- Antileishmanial activities of benzothiazole derivatives
-
Benzothiazole derivatives 1-22 were synthesized from 2-aminothiophenol and all synthetic compounds were screened for in vitro antileishmanial activity. These compound showed different types activities against leishmania with IC50 values ranging
- Rahim, Fazal,Samreen,Taha, Muhammad,Saad, Syed Muhammad,Perveen, Shahnaz,Khan, Momin,Alam, Muhammad Tanveer,Khan, Khalid Mohammed,Choudhary, M. Iqbal
-
p. 157 - 161
(2015/05/20)
-
- IMMUNOSUPPRESSIVE COMPOUNDS
-
The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging 50 values 1.9, 5050), respectively.
- -
-
Paragraph 0023
(2015/01/07)
-
- Synthesis, characterization and 11C-radiolabeling of aminophenyl benzothiazoles: Structural effects on the alkylation of amino group
-
Several aminophenyl benzothiazoles were prepared with a view to using them as amyloid binding agents for imaging β-amyloid in Alzheimer's disease. These precursors were radiolabeled with 11C-positron-emitting radioisotope using an automated synthesizer and selected radiolabeled compounds were further purified by HPLC. Our results demonstrate that changes in structure have a major influence on the radioactive yield and the ease with which the radiolabel can be introduced. Aminophenyl benzothiazoles with an attached isopropyl group resisted dialkylation perhaps due to steric hindrance caused by this group. Straight chain attachment of methyl, ethyl, butyl, and crotyl groups in the structure decreased the radiochemical yield. Notably, the o-aminophenyl benzothiazole derivatives were difficult to alkylate despite stringent experimental conditions. This reactivity difference is attributed to the hydrogen bonding characteristics of the o-amino group with the nitrogen atom of the thiazole ring. Copyright
- Venkatachalam,Stimson,Bhalla,Pierens,Reutens
-
p. 566 - 573
(2014/11/07)
-
- Melamine trisulfonic acid: An efficient and recyclable catalyst for the synthesis of 2-substituted benzothiazoles in aqueous media
-
Melamine trisulfonic acid (MTSA) was found to be an efficient and recyclable catalyst for the synthesis of 2-substituted benzothiazoles from aromatic aldehydes and o-aminothiophenol in excellent yields in water. This method provides a simple and efficient
- Sheik Mansoor,Logaiya,Sudhan,Aswin,Nasir Ahmed,Mohamed Hussain
-
-