105224-04-2

Basic information

• Product Name: Ethanone, 1-(3-methyl-1H-pyrazol-4-yl)- (9CI)
• Synonyms: Ethanone, 1-(3-methyl-1H-pyrazol-4-yl)- (9CI);1-(3-Methyl-1H-pyrazol-4-yl)-ethanone
• CAS NO: 105224-04-2
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14052
• Product Categories: ACETYLGROUP
• Mol File: 105224-04-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(3-methyl-1H-pyrazol-4-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-methyl-1H-pyrazol-4-yl)- (9CI)(105224-04-2)
• EPA Substance Registry System: Ethanone, 1-(3-methyl-1H-pyrazol-4-yl)- (9CI)(105224-04-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 105224-04-2(Hazardous Substances Data)

Upstream product

• 33884-41-2 ethoxylideneacetylacetone 
• 613-94-5 benzoic acid hydrazide 
• 153136-98-2 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole 
• 66373-26-0 1-(4-methyl-2-methylsulfanylpyrimidin-5-yl)ethanone 
• 71043-35-1 3-methoxymethylenepentane-2,4-dione 
• 7732-18-5 water 
• 7803-57-8 hydrazine hydrate 
• 87150-12-7 ethyl 4-acetyl-3-methyl-1H-pyrazole-1-carboxylate 
• 100-63-0 phenylhydrazine 
• 93583-97-2 1-amidino-3-methyl-4-pyrazolyl methylketone amidinohydrazone dihydrochloride 
• 563-41-7 semicarbazide hydrochloride 

Downstream Products

• 52773-23-6 1-(1,3-dimethyl-1H-pyrazol-4-yl)ethan-1-one 
• 21686-05-5 1-(1,5-dimethyl-1H-pyrazol-4-yl)ethan-1-one 
• 5078-59-1 1-β-Hydroxyethyl-4-acetyl-5-methylpyrazol 
• 5078-55-7 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone 

Relevant articles and documents

Use of activated enol ethers in the synthesis of pyrazoles: Reactions with hydrazine and a study of pyrazole tautomerism

Activated enol ethers derived from esters or the dinitrile of malonic acid, or from pentane-2,4-dione were treated with hydrazine hydrate. The structures of the obtained products - pyrazoles 5 - were studied with a focus on tautomerism and supramolecular structure. A reverse addition of the reagents led to the isolation of two novel products, namely bis-enehydrazines 6 with an unsymmetrical arrangement of the formally equivalent subunits.

Reaction of 3-Benzylidene-2,4-pentanedione and 3-Methoxymethylene-2,4-pentanedione with Aroylhydrazines

Aroylhydrazines 2 reacted with 3-benzylidene-2,4-pentanedione (1) to give 1-aroyl-3,5-dimethyl-1H-pyrazoles 5 and benzaldehyde aroylhydrazones 6. From the reaction of 3-methoxymethylene-2,4-pentanedione (7) with aroylhydrazines 2 the unknown N-aroyl-4-acetyl-1H-pyrazoles 9 were exclusively isolated in good yields.