Welcome to LookChem.com Sign In|Join Free

CAS

  • or
METHYL 1-METHYL-3-INDAZOLECARBOXYLATE, with the molecular formula C11H11NO2, is a chemical compound derived from indazolecarboxylic acid and features a methyl ester functional group. It is recognized for its role as a reagent in various chemical reactions and serves as a valuable building block in the synthesis of complex organic molecules, particularly in the production of pharmaceuticals and agrochemicals. Its potential extends to the development of new materials and biochemical research.

109216-60-6

Post Buying Request

109216-60-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

109216-60-6 Usage

Uses

Used in Pharmaceutical Industry:
METHYL 1-METHYL-3-INDAZOLECARBOXYLATE is used as an intermediate in organic synthesis for the production of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 1-METHYL-3-INDAZOLECARBOXYLATE is utilized as a precursor in the synthesis of agrochemicals, aiding in the creation of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Material Science:
METHYL 1-METHYL-3-INDAZOLECARBOXYLATE is employed in the development of new materials, leveraging its chemical properties to engineer innovative substances with potential applications in various industries.
Used in Biochemical Research:
METHYL 1-METHYL-3-INDAZOLECARBOXYLATE is also used as a reagent in biochemical research, facilitating experiments and studies aimed at understanding complex biological processes and the development of novel bioactive molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 109216-60-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,2,1 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 109216-60:
(8*1)+(7*0)+(6*9)+(5*2)+(4*1)+(3*6)+(2*6)+(1*0)=106
106 % 10 = 6
So 109216-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O2/c1-12-8-6-4-3-5-7(8)9(11-12)10(13)14-2/h3-6H,1-2H3

109216-60-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 1-methylindazole-3-carboxylate

1.2 Other means of identification

Product number -
Other names Methyl-1-methylindazole-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109216-60-6 SDS

109216-60-6Relevant articles and documents

Base-Catalyzed Transesterification of Thionoesters

Newton, Josiah J.,Britton, Robert,Friesen, Chadron M.

, p. 12784 - 12792 (2018/10/20)

Here we report a convenient synthesis of thionoesters by base-catalyzed transesterification. Benzyl and alkyl thionobenzoates and thionoheterobenzoates were efficiently prepared using various alcohols catalyzed by the corresponding sodium alkoxide. This methodology features a broad substrate scope, good to excellent yields, short reaction times, while simultaneously driving the reaction toward completion through the removal of the methanol byproduct. We also report the conversion of a small collection of thionobenzoates into the corresponding α,α-difluorobenzyl ethers to demonstrate the conversion of alcohols into difluorobenzyl or difluoroheterobenzyl ethers, a process that could prove useful for lead optimization in medicinal chemistry.

Sulfocoumarin-, Coumarin-, 4-Sulfamoylphenyl-Bearing Indazole-3-carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor-Associated Carbonic Anhydrase Isozymes IX and XII

Angapelly, Srinivas,Sri Ramya,Angeli, Andrea,Supuran, Claudiu T.,Arifuddin, Mohammed

, p. 1578 - 1584 (2017/10/16)

A series of sulfocoumarin-, coumarin-, and 4-sulfamoylphenyl-bearing indazole-3-carboxamide hybrids were synthesized and investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms I and II (cytosolic isozymes), as well as hCA IX and XII (transmembrane, tumor-associated enzymes). Compounds 6 a–g (amide derivatives) and 7 a–h (triazoles) act as “prodrugs”, and their hydrolysis products are the de facto CA inhibitors. These compounds displayed sub-micromolar to high-nanomolar inhibitory activity against hCA isoforms IX and XII, which were recently validated as antitumor drug targets. Moreover, no inhibition of the off-target hCA I and II isoforms was observed. Compounds 8 a–f (another set of triazoles) exhibited nanomolar inhibition against hCA isoforms I, II, IX and XII, among which compounds 8 c, 8 d, and 8 f were found to inhibit the tumor-associated hypoxia-induced hCA isoform IX with Ki values of 1.8, 2.3, and 2.0 nm respectively. Further exploration of these compounds could be useful for the development of novel antitumor agents with selective mechanisms of CA inhibitory action.

Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity

Ali, Nasir Ali Shafakat,Zakir, Shaikh,Patel, Muqtadir,Farooqui, Mazahar

experimental part, p. 39 - 43 (2012/07/02)

We are reporting herein for the first time the synthesis of α-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it h

Efficient syntheses of exo-granisetron hydrochloride and other potential impurities present in granisetron hydrochloride, an anti-emetic drug

Vishnu, Eda V.R.,Joseph, Suju,Srinivasana, Abayee K.,Gania, Ramesh S.,Reddy, Govindabur R.,Rao, Patakokila V.,Dahanukara, Vilas H.,Ramanatham, Josyula,Devanna, Nayakanti

experimental part, p. 722 - 727 (2012/05/04)

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

Fab I inhibitors

-

Page column 18, (2010/02/06)

Compounds of formula (I) and (II) are disclosed wherein, R1, R2, R3, R4, X, A, B, D and Q are as disclosed in the specification, and the compounds are FabI inhibitors useful in the treatment of bacterial infecti

DERIVATIVES OF AMIDE ANALOGS OF CERTAIN METHANO BRIDGED QUINOLIZINES

-

, (2008/06/13)

This invention relates to novel amide derivatives of certain 2, 6-methano-2H-quinolizine-type compounds, to the intermediates and processes for their preparation, to their ability to antagonize the effects of serotonin at the 5HT 3 receptors, and to their end-use application in the treatment of chemotherapeutically-induced nausea and vomiting, as anti-anxiety agents, in the symptomatic treatment of pain associated with migraine, as anti-arrhythmic agents, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses of the type manifested in patients suffering from schizophrenia, and mania, in the treatment of glaucoma, for stimulating gastric motility, to combat drug abuse, to treat sleep apnea and to treat irritable bowel syndrome.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 109216-60-6