1176316-99-6Relevant articles and documents
Melatonin compounds and preparation method and applications thereof
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Paragraph 0017, (2018/01/03)
The invention relates to melatonin compounds and clinical applications thereof. The structure of the melatonin compounds is represented by the formula (I). The invention also provides hydrates, solvates, eutectic, and pharmaceutically acceptable salts of the melatonin compounds represented by the formula (I), and a preparation method thereof. The invention also provides a medical application of the melatonin compounds, in particular, treatment on depression or periventricular leukomalacia.
NEW CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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Paragraph 0043 - 0045, (2014/02/15)
The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.
CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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Paragraph 0074, (2014/02/15)
The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.
MIXED CRYSTAL AGOMELATINE (FORM-VIII), PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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Paragraph 0045 - 0049, (2014/02/15)
The present invention provides a mixed crystalline form VIII of agomelatine, its method of preparation, application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests, it has been found to be superior to the crystalline form VI in terms of stability. As a result, the crystalline form VIII of the present invention possesses advantages in pharmaceutical preparation.
AGOMELATINE HYDROCHLORIDE HYDRATE AND PREPARATION THEREOF
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Page/Page column 2, (2013/02/28)
The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.
PROCESS FOR THE PREPARATION OF N-[2- (7-METHOXY-L-NAPHTHYL) ETHYL] ACETAMIDE AND ITS NOVEL CRYSTALLINE FORMS
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, (2012/04/23)
The present invention relates to a process for the preparation of N-[2-(7-methoxy-l-naphthyl)ethyl]acetamide compound of formula-1 and novel crystalline forms of its intermediates as well as the final compound.
AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF
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Page/Page column 4, (2012/03/08)
The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.
AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF
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Page/Page column 2, (2012/01/13)
The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.
AGOMELATINE HYDROCHLORIDE HYDRATE AND PREPARATION THEREOF
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Page/Page column 3, (2011/10/10)
An agomelatine hydrochloride hydrate of formula (I), preparation, use, and pharmaceutical composition thereof are provided. Said hydrate obtained through the present method has significant increased solubi1ity than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. Using the present method, high purity can be obtained through a simple process, free of any complicated steps. Wherein X is Cl.
