117873-72-0

Basic information

• Product Name: 2,6-Dibromo-4-methoxypyridine
• Synonyms: 2,6-Dibromo-4-methoxypyridine;Pyridine,2,6-dibromo-4-methoxy-
• CAS NO: 117873-72-0
• Molecular Formula: C₆H₅Br₂NO
• Molecular Weight: 266.92
• Mol File: 117873-72-0.mol

Chemical Properties

• Melting Point: 136 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 283°Cat760mmHg
• Flash Point: 124.9°C
• Appearance: /
• Density: 1.919g/cm³
• Vapor Pressure: 0.00556mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.35±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dibromo-4-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dibromo-4-methoxypyridine(117873-72-0)
• EPA Substance Registry System: 2,6-Dibromo-4-methoxypyridine(117873-72-0)

Safety Data

• Hazardous Substances Data: 117873-72-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dibromo-4-methoxypyridine is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
2,6-Dibromo-4-methoxypyridine is used as a valuable reactant for the preparation of a wide range of organic compounds, including pyridine-pyridone alternate oligomers and cyclic adenosine monophosphate (cAMP). These compounds have diverse applications in various fields, such as biochemistry, molecular biology, and medicinal chemistry.

InChI:InChI=1/C6H5Br2NO/c1-10-4-2-5(7)9-6(8)3-4/h2-3H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 175422-04-5 2,6-dibromo-4-nitropyridine 
• 2408-70-0 2,4,6-tribromopyridine 
• 67-56-1 methanol 

Downstream Products

• 117873-75-3 6,6'-Diacetyl-4,4'-dimethoxy-2,2'-bipyridin 
• 192447-50-0 2-bromo-4-methoxy-6-[3-(trifluoromethyl)phenoxy] pyridine 
• 193074-41-8 2-bromo-4-methoxy-6-{3-(trifluoromethoxy)phenoxy} pyridine 
• 1158786-59-4 6-bromo-4-methoxypyridin-2-amine 
• 205052-93-3 6-bromo-4-methoxy-2,2'-bipyridine 

Relevant articles and documents

ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituants are as defined in the claims.

N-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides

N-(substituted or unsubstituted)-4-substituted-6-(substituted or unsubstituted) phenoxy-2-pyridine carboxamide or thiocarboxamide represented by the general formula (I) and a process for producing the compound. A herbicide containing as an effective ingredient N-(substituted or unsubstituted)-4-substituted-6-(substituted or unsubstituted) phenoxy-2-pyridine carboxamide or thiocarboxamide represented by the general formula (I).

Process for producing pyridinecarboxamides or thiocarboxamides

A process for producing N-substituted pyridine carboxamide or thiocarboxamide, comprising reacting a substituted or unsubstituted pyridine metal compound with substituted isocyanate or isothiocyanate to obtain an addition reaction product thereof, and then substituting the metal of said addition reaction product with a proton. The process according to the present invention can be applied even to compounds having an oxidation-susceptible substituent group and, therefore, industrially useful.

2-(unsubstituted or substituted) (benzyloxy or phenoxy)-4-substituted-6-(meta-substituted phenoxy)pyridine, process for producing the same, and herbicidal composition

A 2-(unsubstituted or substituted) (benzyloxy or phenoxy)-4-substituted-6-(meta-substituted phenoxy)pyridine represented by the formula (I): STR1 wherein R represents C1 -C4 alkoxy or cyano; each X, which may be identical or different if n is greater than 1, represents a halogen, C1 -C4 alkoxy, C1 -C4 alkyl, C1 -C4 haloalkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkythio, C3 -C5 alkenyloxy, or C3 -C5 alkynyloxy; Y represents trifluoromethyl, difluoromethoxy, trifluoromethoxy, or trifluoromethylthio; m represents an integer of 0 or 1; and n represents an integer of 0 to 5, which is useful as a herbicide.

7. Lanthanide Complexes of Polyacid Ligands Derived from 2,6-Bis(pyrazol-1-yl)pyridine, Pyrazine, and 6,6′-Bis(pyrazol-1-yl)-2,2′-bipyridine: Synthesis and Luminescence Properties

The synthesis of three novel pyrazole-containing complexing acids, N,N,N′,N′-{2,6-bis[3-(aminomethyl)pyrazol-1-yl]-4-methoxypyridine} tetrakis(acetic acid) (1), N,N,N′, N′-{2,6-bis[3-(aminomethyl)pyrazol-1-yl]pyrazine}tetrakis(acetic acid) (2), and N,N,N′,N′-{6,6′-bist[3-(aminomethyl)pyrazol-1-yl]-2,2′- bipyridine}tetrakis(acetic acid) (3) is described. Ligands 1-3 formed stable complexes with EuIII, TbIII, SmIII and DyIII in H2O whose relative luminescence yields, triplet-state energies, and emission decay lifetimes were measured. The number of H2O molecules in the first coordination sphere of the lanthanide ion were also determined. Comparison of data from the EuIII and TbIII complexes of 1-3 and those of the parent trisheterocycle N,N,N′,N′-{2,6-bis[3-(aminomethyl)pyrazol-1-yl]pyridine} tetrakis(acetic acid) showed that the modification of the pyridine ring for pyrazine or 2,2′-bipyridine strongly modify the luminescence properties of the complexes. MeO Substitution at C(4) of 1 maintain the excellent properties described for the parent compound and give an additional functional group that will serve for attaching the label to biomolecules in bioaffinity applications.