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Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate), also known as ethylene glycol monomethyl ether sulfate, is a chemical compound that serves as a surfactant in a variety of industrial and household applications. It is characterized by its clear, colorless appearance and a slightly sweet odor. Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate) is considered relatively safe for use in products such as detergents, cleaners, and personal care items when handled with proper care, exhibiting low volatility and low toxicity potential.

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  • 118591-58-5 Structure
  • Basic information

    1. Product Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
    2. Synonyms: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate);2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate;Tos-PEG2-alcohol;Tos-PEG2-OH
    3. CAS NO:118591-58-5
    4. Molecular Formula: C11H16O5S
    5. Molecular Weight: 260.30674
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 118591-58-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 427.4±30.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.256±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 14.32±0.10(Predicted)
    10. CAS DataBase Reference: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)(118591-58-5)
    12. EPA Substance Registry System: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)(118591-58-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 118591-58-5(Hazardous Substances Data)

118591-58-5 Usage

Uses

Used in Detergent Industry:
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate) is used as a surfactant for its ability to reduce the surface tension of water, enhancing the cleaning power of detergents and making them more effective at removing dirt and stains.
Used in Cleaning Products:
In the cleaning products industry, this chemical compound is utilized as a surfactant to improve the solubility of other ingredients and to facilitate the removal of grease and grime from various surfaces.
Used in Personal Care Industry:
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate) is used as a component in personal care products to help stabilize emulsions and suspensions, ensuring the even distribution of active ingredients throughout the product for optimal performance and safety.
It is crucial to adhere to proper handling and safety protocols when working with this chemical to minimize any potential health risks, despite its relatively safe profile in designated applications.

Check Digit Verification of cas no

The CAS Registry Mumber 118591-58-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,5,9 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 118591-58:
(8*1)+(7*1)+(6*8)+(5*5)+(4*9)+(3*1)+(2*5)+(1*8)=145
145 % 10 = 5
So 118591-58-5 is a valid CAS Registry Number.

118591-58-5Relevant articles and documents

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors

Sadrerafi, Keivan,Mason, Emilia O.,Lee, Mark W.

, p. 987 - 995 (2018)

Purpose: Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4′-(trans-3″-(3′″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt)

Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes

Song, Rita,Kim, Yeong-Sang,Lee, Chong Ock,Sohn, Youn Soo

, p. 1537 - 1540 (2003)

A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line.

Gold nanoparticles coated with semi-fluorinated oligo(ethylene glycol) produce sub-100 nm nanoparticle vesicles without templates

Niikura, Kenichi,Iyo, Naoki,Higuchi, Takeshi,Nishio, Takashi,Jinnai, Hiroshi,Fujitani, Naoki,Ijiro, Kuniharu

, p. 7632 - 7635 (2012)

Gold nanoparticles (NPs) with diameters of 5, 10, and 20 nm coated with semifluorinated oligo(ethylene glycol) ligands were formed into sub-100 nm hollow NP assemblies (NP vesicles) in THF without the use of a template. The NP vesicles maintained their st

Stable pillar[5]arene-based pseudo[1]rotaxanes formed in polar solution

Wu, Xuan,Gao, Lei,Sun, Junzhao,Hu, Xiao-Yu,Wang, Leyong

, p. 1655 - 1660 (2016)

Mono-alkyl-functionalized pillar[5]arenes P1, P2, and P3 were synthesized by click reaction, which exhibited different self-assembly behavior in polar solvent DMSO. Stable pseudo[1]rotaxane was formed by the self-complexation from P1 or P2, whereas, concentration-dependent pseudorotaxane structures were generated by P3 which bearing more flexible side chain. Interestingly, the obtained pseudo[1]rotaxanes exhibited a dynamic fast assembly process upon adding NaBF4, resulting in the formation of Na+-induced pseudorotaxanes.

Synthesis of optically active 1,1′-binaphthyl-phthalocyanines linked via a crown ether unit

Liu, Hong-Wei,Chen, Chuan-Fu,Ai, Min,Gong, Ai-Jun,Jiang, Jing,Xi, Fu

, p. 4915 - 4922 (2000)

Novel optically active metal and metal-free phthalocyanines, substituted with 1,1′-binaphthyl crown ether units, have been synthesized and characterized.

Pegylated triarylmethanes: Synthesis, antimicrobial activity, anti-proliferative behavior and in silico studies

Abdmouleh, Fatma,Ali, Mamdouh Ben,Arbi, Mehdi El,Ferroud, Clotilde,Goya-Jorge, Elizabeth,Guenineche, Léna,Lagarde, Nathalie,Liagre, Bertrand,Martin, Frédérique,Ricco, Christophe,Riccobono, Charlotte,Veitía, Maité Sylla-Iyarreta

, (2020)

We describe herein the synthesis, characterization and biological studies of novel PEGylated triarylmethanes. Non-symmetrical and symmetrical triarylmethanes series have been synthesized by Friedel-Crafts hydroxyalkylation or directly from bisacodyl respectively followed by a functionalization with PEG fragments in order to increase bioavailability and biological effectiveness. The antimicrobial activity was investigated against Gram-positive and Gram-negative foodborne pathogens and against Candida albicans, an opportunistic pathogenic yeast. The anti-biocidal activity was also studied using Staphylococcus aureus as a reference bacterium. Almost all PEGylated molecules displayed an antifungal activity comparable with fusidic acid with MIC values ranging from 6.25 to 50 μg/mL. Compounds also revealed a promising antibiofilm activity with biofilm eradication percentages values above 80% for the best molecules (compounds 4d and 7). Compounds 7 and 8b showed a modest antiproliferative activity against human colorectal cancer cell lines HT-29. Finally, in silico molecular docking studies revealed DHFR and DNA gyrase B as potential anti-bacterial targets and in silico predictions of ADME suggested adequate drug-likeness profiles for the synthetized triarylmethanes.

Closing the Loop: Triazolylpyridine Coordination Drives the Self-Assembly of Metallomacrocycles with Tunable Topologies for Small-Molecule and Guanine-Quadruplex Recognition

Miron, Caitlin E.,Colden Leung, Madelaine R.,Kennedy, Emily I.,Fleischel, Olivier,Khorasani, Mona Ashraf,Wu, Nan,Mergny, Jean-Louis,Petitjean, Anne

, p. 18718 - 18734 (2018)

The 2-(1,2,3-triazol-4-yl)pyridine motif, with its facile “click” synthesis and remarkable coordinative properties, is an attractive chelate for applications in the metal-directed self-assembly of intricate three-dimensional structures. Organic ligands th

Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide

Zhang, Fangqing,Wu, Zhenwei,Chen, Pan,Zhang, Jian,Wang, Tao,Zhou, Jinpei,Zhang, Huibin

, (2020)

BRD4 has emerged as an attractive target for anticancer therapy. However, BRD4 inhibitors treatment leads to BRD4 protein accumulation, together with the reversible nature of inhibitors binding to BRD4, which may limit the efficacy of BRD4 inhibitors. To address these problems, a protein degradation strategy based on the proteolysis targeting chimera (PROTAC) technology has been developed to target BRD4 recently. Herein, we present our design, synthesis and biological evaluation of a new class of PROTAC BRD4 degraders, which were based on a potent dihydroquinazolinone-based BRD4 inhibitor compound 6 and lenalidomide/pomalidomide as ligand for E3 ligase cereblon. Gratifyingly, several compounds showed excellent inhibitory activity against BRD4, and high anti-proliferative potency against human monocyte lymphoma cell line THP-1. Especially, compound 21 (BRD4 BD1, IC50 = 41.8 nM) achieved a submicromolar IC50 value of 0.81 μM in inhibiting the growth of THP-1 cell line, and was 4 times more potent than compound 6. Moreover, the mechanism study established that 21 could effectively induce the degradation of BRD4 protein and suppression of c-Myc. All of these results suggested that 21 was an efficacious BRD4 degrader for further investigation.

SYNTHESIS OF 2-(2-AMINOETHOXY) ETHANOL

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Paragraph 0055-0057, (2021/02/12)

A method for synthesizing 2-(2-aminoethoxy) ethanol, including the steps of producing 2-(2-phthalimidoethoxy) ethanol by reacting 5-tosyloxy-3-oxapentanol with potassium phthalate and converting the 2-(2-phthalimidoethoxy) ethanol to the 2-(2-aminoethoxy) ethanol by reacting the 2-(2-phthalimidoethoxy) ethanol with hydrazine monohydrate. Reacting the 2-(2-phthalimidoethoxy) ethanol with the hydrazine monohydrate may include forming a final mixture by adding the hydrazine monohydrate to a solution of 2-(2-phthalimidoethoxy) ethanol, refluxing the final mixture in a nitrogen atmosphere, extracting a second organic phase containing the 2-(2-aminoethoxy) ethanol from the final mixture using a second portion of chloroform, and purifying the 2-(2-aminoethoxy) ethanol from the second organic phase.

Fluorescent Columnar Liquid-Crystalline Polymers: Synthesis, Mesomorphic Behaviors and Tunable Emission Wavelengths?

Hao, Xiangnan,Mu, Bin,Tian, Wei,Zhang, Zhelin,Zhao, Yu

supporting information, p. 2009 - 2015 (2021/06/08)

Fluorescent columnar liquid-crystalline polymers have attracted intensive attention due to their unique features that can be applied in many fields. However, the utilization of molecular engineering to achieve efficient fluorescence tuning has rarely been

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