118689-07-9

Basic information

• Product Name: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
• Synonyms: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol;2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propane-1,2-diol;Fluconazole Diol IMpurity;Fluconazole EP Impurity F;Fluconazole impurity F (EP)
• CAS NO: 118689-07-9
• Molecular Formula: C₁₁H₁₁F₂N₃O₂
• Molecular Weight: 255.223
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 118689-07-9.mol

Chemical Properties

• Boiling Point: 490.042 °C at 760 mmHg
• Flash Point: 250.168 °C
• Appearance: /
• Density: 1.42
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(118689-07-9)
• EPA Substance Registry System: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(118689-07-9)

Safety Data

• Hazardous Substances Data: 118689-07-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol is used as a diol impurity in the production of the antifungal agent Fluconazole (F421000). Its presence is significant for the development and formulation of Fluconazole, which is widely used to treat various fungal infections.
Used in Quality Control and Regulatory Compliance:
In the pharmaceutical sector, 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol, also known as Fluconazole EP Impurity F, is utilized for quality control purposes. It helps ensure that the final product meets the required standards and regulatory guidelines, contributing to the safety and efficacy of the antifungal medication.
While the provided materials do not explicitly mention other applications for 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol, its chemical structure and properties may suggest potential uses in various chemical or pharmaceutical processes. However, without further information, it is not possible to list additional applications with certainty.

InChI:InChI=1/C11H11F2N3O2/c12-8-1-2-9(10(13)3-8)11(18,5-17)4-16-7-14-6-15-16/h1-3,6-7,17-18H,4-5H2

Upstream product

• 159553-75-0 Acetic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 149809-36-9 Toluene-4-sulfonic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 288-88-0 1,2,4-Triazole 
• 219923-95-2 3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol 
• 584-08-7 potassium carbonate 
• 156570-15-9 1-(2-(2,4-difluorophenyl)allyl)-1H-1,2,4-triazole 
• 86386-77-8 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 
• 149882-16-6 (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 141113-42-0 (S)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 847952-06-1 2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propionic acid 

Downstream Products

• 159553-75-0 Acetic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 219923-96-3 (2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole 
• 219923-97-4 (2S)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole 
• 137234-63-0 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 137234-62-9 voriconazole 
• 219923-85-0 (2S-cis)-1-{4-[4-(4-{[4-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-2-yl]methoxy}phenyl)-piperazin-1-yl]phenyl}-3-(1-methylethyl)-2-imidazolidinone 
• 219923-85-0 1-[4-(4-{4-[(2R,4S)-4-(2,4-Difluoro-phenyl)-4-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-2-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-3-isopropyl-imidazolidin-2-one 
• 141113-41-9 (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol 

Relevant articles and documents

Triazole aromatic alcohol heterocyclic ether derivative and preparing method and application thereof

The invention relates to a triazole aromatic alcohol heterocyclic ether derivative and the preparing method and application thereof, and particularly provides the general structure, crystal form, pharmaceutically acceptable inorganic acid salt or organic acid salt, aquo-complex, and solvate or prodrug of the triazole aromatic alcohol heterocyclic ether derivative. In-vitro and in-vivo bacteriostasis experiments prove that the compound has remarkable activity in inhibiting human body pathomycete candida albicans, candida parapsilosis, cryptococcus neoformans, candida glabrata, aspergillus fumigates, gypseous microsporum and trichophyton rubrum, and the activity is higher than that of fluconazole. Furthermore, the compound has the advantages of being low in toxicity, wide in antifungal spectrum and the like, and therefore the compound can be used for preparing antifungal drugs.

Palladium-catalyzed direct oxidation of alkenes with molecular oxygen: General and practical methods for the preparation of 1, 2-diols, aldehydes, and ketones

(Figure Presented) 1, 2-Diols, aldehydes, and ketones are important intermediates in chemical synthesis, and alkenes are possible precursors for 1, 2-diols, aldehydes, and ketones. Herein, novel and environmentally benign methods for palladium-catalyzed dihydroxylation and oxidative cleavage of olefins with oxygen as sole oxidant are presented. The cleavage reactions were performed with acid as additive in aqueous solution, whereas 1, 2-diols were formed in the presence of base. A broad substrate scope has been demonstrated allowing monosubstituted aromatic and aliphatic terminal alkenes, 1, 2-disubstituted, and 1, 1-disubstituted olefins. The cleavage reactions of dioxo-PdII complexes implicate 1, 2-diol might act as a key intermediate of olefin cleavage.

Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology

In search for new compounds with potential for clinical use as antifungal agents in dermatology, a series of 12 azole compounds were synthesized stereospecifically and investigated specifically for their activity against dermatophyte fungal infections in

2,4,4-trisubstituted-1,3-dioxolane antifungals

The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or 3; X is N or CH; each R1independently is halo, ni

Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof

A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: STR1

PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012

Porcine pancreatic lipase (PPL) catalysis has been used to establish both stereocenters of the cis-(tetrahydrofuranylmethyl) tosylate 4. In addition to the enzymatic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of 2, successful enzymatic resolution of the racemic diol 10 provided an alternate route to the important precursor 1.

2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds

Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula STR1 wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo