120926-96-7

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate
• Synonyms: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate
• CAS NO: 120926-96-7
• Molecular Weight: 302.414
• Mol File: 120926-96-7.mol

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate(120926-96-7)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate(120926-96-7)

Safety Data

• Hazardous Substances Data: 120926-96-7(Hazardous Substances Data)

Upstream product

• 2216-51-5 (-)-menthol 
• 5524-56-1 ethyl 2-p-tolyl-2-oxoacetate 
• 108-88-3 toluene 
• 197660-65-4 (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl (4-methylphenyl)acetate 
• 622-47-9 4-tolylacetic acid 

Downstream Products

• 56031-84-6 (R)-(-)-p-methyl atrolactic acid 
• 4166-98-7 4-methyl-benzilic acid 
• 1257420-16-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methylphenyl)butanoate 
• 1452815-96-1 C₂₇H₃₅NO₅ 
• 1452815-97-2 C₁₈H₁₉NO₅ 
• 1452815-90-5 C₂₂H₂₂N₂O₅ 
• 1452815-91-6 C₂₂H₂₄N₂O₃ 
• 1452815-92-7 C₂₂H₂₃NO₃ 
• 1452815-87-0 (R)-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1452815-93-8 C₂₂H₂₂INO₃ 
• 1452815-94-9 C₂₂H₂₂BrNO₃ 
• 1452816-01-1 (R)-6-ethyl-2-iodo-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1452816-02-2 (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1258305-05-3 α-ethyl-α-hydroxy-4-methylbenzeneacetic acid 

Relevant articles and documents

Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters

Electrochemical oxygen reduction reaction (ORR) is a powerful tool for introducing oxygen functional groups in synthetic chemistry. However, compared with the well-developed one-electron oxygen reduction process, the applications of two-electron oxygen re

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

We developed a novel and convenient stereoselective path for the preparation of pyrrolo-1,5-benzoxazepinones (PBOs). This innovative route envisaged the employment of (-)-menthol as convenient chiral auxiliary and a key SNAr for the stereoselective preparation of a tertiary aryl-alkyl ether. As a further advancement, we exploited this newly conceived synthetic route for the preparation of 2-substituted PBO analogues to either undergo biological evaluation themselves or give access to a variety of further functionalization options.

The stereoselective synthesis of 2-aryl-2-hydroxybutanoic acid via menthyl chiral auxiliaries

In the presence of titanium(IV) tetraethoxide ((EtO)4Ti), menthyl arylglyoxylates are prepared by transesterification of ethyl arylglyoxylates and natural (-)-(1R,2S,5R)-menthol. Using menthyl as a chiral auxiliary, the corresponding novel (R)-menthyl 2-aryl-2-hydroxybutanoates are synthesized by the addition of Et2Zn with menthyl arylglyoxylates. The structures of the products are characterized by IR and 1H- and 13C-NMR spectroscopy, mass spectrometry, and elemental analysis. The diastereoselectivities are analyzed by HPLC. The addition reactions are completed with good yields and high diastereoisomeric excess (de up to 95%), and, after hydrolysis, the (R)-2-aryl-2-hydroxybutanoic acids are obtained with high optical purities.