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124598-28-3

4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 124598-28-3 Structure

  • Basic information

    1. Product Name: 4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE
    2. Synonyms: OTAVA-BB BB7020240325;4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE
    3. CAS NO:124598-28-3
    4. Molecular Formula: C12H8ClN3S
    5. Molecular Weight: 261.73
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 124598-28-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE(124598-28-3)
    11. EPA Substance Registry System: 4-CHLORO-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE(124598-28-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 124598-28-3(Hazardous Substances Data)

124598-28-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 124598-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,5,9 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 124598-28:
(8*1)+(7*2)+(6*4)+(5*5)+(4*9)+(3*8)+(2*2)+(1*8)=143
143 % 10 = 3
So 124598-28-3 is a valid CAS Registry Number.

124598-28-3Relevant articles and documents

Metalation of diazines X: First halogen migration during metalation of pyrimidines unusual halogen-lithium exchange with LTMP new synthesis of Leshmaniacides

Ple,Turck,Couture,Queguiner

, p. 10299 - 10308 (1994)

An halogen migration of iodine during the metalation of pyrimidines has been highlighted and a mechanism is proposed. An unusual halogen-lithium exchange with LTMP has been observed. A new synthetic route to Leshmaniacides using metalation and cross coupl

Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores

Farghaly, Ahmed M.,AboulWafa, Omaima M.,Elshaier, Yaseen A. M.,Badawi, Waleed A.,Haridy, Haridy H.,Mubarak, Heba A. E.

, p. 360 - 379 (2019/02/03)

A new series of achiral pyrimidine derivatives based on nifedipine-like structure was designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones, acetohydrazide, differently substituted benzylidene functionalities, benzosulfohyd

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids

Kaur, Hardeep,Balzarini, Jan,De Kock, Carmen,Smith, Peter J.,Chibale, Kelly,Singh, Kamaljit

, p. 52 - 62 (2015/06/30)

Abstract A series of hybrids comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of py

Palladium-catalyzed cross-coupling reaction of 2- and/or 5-substituted 4,6-dichloropyrimidines with arylboronic acids

Tumkevicius,Dodonova,Baskirova,Voitechovicius

experimental part, p. 960 - 964 (2009/12/06)

(Chemical Equation Presented) The Suzuki-Miyaura reaction of some 4,6-dichloropyrimidines bearing methylthio-, methyl-, amino-, cyano-, formyl-, and nitro groups in positions 2 and/or 5 of the pyrimidine ring with arylboronic acids has been investigated. Influence of palladium catalyst, ligand, base, and solvent on the reaction outcome was studied. The reaction was found to give the corresponding 4,6-diarylpyrimidines in reasonable yields using Pd(OAc) 2/PPh3/K3PO4 or Pd(PPh 3)2Cl2/K3PO4 as catalyst systems.

REACTIONS WITH 2-METHYLTHIOPYRIMIDINES, SYNTHESIS OF SOME NEW FUSED PYRIMIDINES

El-Reedy, A. M.,Hussain, S. M.,Ali, A. S.,Abdel-Motty, F.

, p. 231 - 236 (2007/10/02)

4-Chloro-2-methylthio -6-phenylpirimidine-5-carbonitrile (II) reacts with hydrazine hydrate to yield the 2,4-dihydrazino derivative (IIId).Compound IIId reacts with nitrous acid to give ditetrazolopyrimidine (VI) and with carbon disulphide to form pyrazolo-s-triazolopyrimidine (VII).The reaction of II with phenylhydrazine affords directly the pyrazolo-pyrimidinederivative (IV).Also, compound II reacts with anthranilic acid to form 2-methylthio-4-phenyl-6-(o-carboxyphenylamino)pyrimidine-5-carbonitrile IIIe) which can bee cyclised into 1-methylthio-10-oxo-3-phenyl-10-pyrimidoquinazoline-4-carbonitrile (IX) by heating with acetic anhydride.Key words: Methylthiopyrimidine; chloropyrimidine; hydrazinopyrimidine; pyrimidoquinazolinone.

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