125035-34-9

Basic information

• Product Name: 2-CHLORO-3-(2-THENOYL)PYRIDINE
• Synonyms: 2-CHLORO-3-(2-THENOYL)PYRIDINE
• CAS NO: 125035-34-9
• Molecular Formula: C₁₀H₆ClNOS
• Molecular Weight: 223.68
• Mol File: 125035-34-9.mol

Chemical Properties

• Boiling Point: 373.1°C at 760 mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 9.19E-06mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 2-CHLORO-3-(2-THENOYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-(2-THENOYL)PYRIDINE(125035-34-9)
• EPA Substance Registry System: 2-CHLORO-3-(2-THENOYL)PYRIDINE(125035-34-9)

Safety Data

• Hazardous Substances Data: 125035-34-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H6ClNOS/c11-10-7(3-1-5-12-10)9(13)8-4-2-6-14-8/h1-6H

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 
• 7646-78-8 tin(IV) chloride 
• 109-09-1 2-chloropyridine 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 332134-11-9 (2-methoxypyridin-3-yl)(thiophen-2-yl)methanone 
• 129182-81-6 2-(6-dimethylaminohexyloxy)-3-(2-thenoyl)pyridine 

Relevant articles and documents

Synthesis of 3-arylthieno[2,3-b]-, -[2,3-c]- or -[3,2-c]pyridines utilizing an interrupted pummerer reaction

An efficient procedure for the synthesis of three types of thienopyridines has been developed. Thus, 3-(1-arylethenyl)-2-(ethylsulfinyl)pyridines, 4-(1-arylethenyl)-3-(ethylsulfinyl)pyridines, and 3-(1-arylethenyl)-4- (ethylsulfinyl)pyridines, which can be easily prepared from the respective aryl chloropyridinyl ketones in a three-step sequence, undergo an interrupted Pummerer reaction on treatment with excess acetic anhydride at temperatures ranging from 100 to 130 C to give 3-arylthieno[2,3-b]pyridines, 3-aryl-thieno[2,3-c]pyridines, and 3-arylthieno[3,2-c]pyridines, respectively. Georg Thieme Verlag Stuttgart - New York.

Quinuclidine compounds and drugs containing the same as the active ingredient

The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In which R1 represents (1) hydrogen atom or (2) hydroxyl group; HAr represents an aromatic heterocycle which may be substituted with 1 to 3 groups; Ar represents an optionally substituted aromatic ring; W represents a chain represented by (1) —CH2—CH2— which may be substituted, (2) —CH=CH— which may be substituted, (3) —C≡C—, (4) —NH—CO—, (5) —CO—NH—, (6) —NH—CH2—, (7) —CH2—NH—, (8) —CH2—CO—, (9) —CO—CH2—, (10) —NH—S(O)l—, (11) —S(O)l—NH—, (12) —CH2—S(O)— or (13) —S(O)l—CH2— (l denotes 0, 1 or 2); and X represents a chain represented by (1) a single bond, (2) an optionally substituted C1-6 alkylene chain, (3) an optionally substituted C2-6 alkenylene chain, (4) an optionally substituted C2-6 alkynylene chain, (5) a formula —Q— (wherein Q represents oxygen atom, sulfur atom, CO or N(R2) (wherein R2 represents a C1-6 alkyl group or a C1-6 alkoxy group)), (6) —NH—CO—, (7) —CO—NH—, (8) —NH—CH2—, (9) —CH2—NH—, (10) —CH2—CO—, (11) —CO—CH2—, (12) —NH—S(O)m—, (13) —S(O)m—NH—, (14) —CH2—S(O)m—, (15) —S(O)m—CH2— (wherein m denotes 0, 1 or 2) or (16) —(CH2)n—O— (wherein n denotes an integer from 1 to 6).

Pyrido[2,3-D]pyrimidine derivatives and pharmaceutical compositions thereof

PCT No. PCT/JP96/03389 Sec. 371 Date Apr. 30, 1998 Sec. 102(e) Date Apr. 30, 1998 PCT Filed Nov. 20, 1996 PCT Pub. No. WO97/19078 PCT Pub. Date May 29, 1997This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a func

Pyridine compounds and pharmaceutical use thereof

A novel pyridine compound of the formula STR1 wherein each symbol is as defined in the specification, or a salt thereof which exhibit inhibitory activity or prolylendopeptidase and a pharmaceutical use thereof are disclosed.