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3-[(1H-Pyrrole-2-carbonyl)-amino]propionic acid is a synthetic amino acid derivative characterized by the molecular formula C8H10N2O3. It features a pyrrole-2-carbonyl group attached to the nitrogen atom of the amino acid, endowing it with unique structural and chemical properties. 3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID is not found naturally but can be created in the laboratory, making it a versatile component in the synthesis of peptides and other bioactive molecules.

129053-84-5

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129053-84-5 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
3-[(1H-Pyrrole-2-carbonyl)-amino]propionic acid serves as a valuable building block in the synthesis of peptides and other bioactive molecules, contributing to the advancement of pharmaceutical research and drug development. Its distinctive structure and properties may offer novel therapeutic avenues and enhance the efficacy of existing treatments.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-[(1H-Pyrrole-2-carbonyl)-amino]propionic acid is utilized as a key component for creating complex organic compounds and pharmaceutical agents. Its unique pyrrole-2-carbonyl group allows for the development of innovative synthetic pathways and the production of new chemical entities with potential applications in various industries.
Further research and studies are essential to fully explore the potential uses and effects of 3-[(1H-Pyrrole-2-carbonyl)-amino]propionic acid, as its unique structure and properties may lead to breakthroughs in various scientific and medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 129053-84-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,0,5 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 129053-84:
(8*1)+(7*2)+(6*9)+(5*0)+(4*5)+(3*3)+(2*8)+(1*4)=125
125 % 10 = 5
So 129053-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O3/c11-7(12)3-5-10-8(13)6-2-1-4-9-6/h1-2,4,9H,3,5H2,(H,10,13)(H,11,12)

129053-84-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1H-pyrrole-2-carbonylamino)propanoic acid

1.2 Other means of identification

Product number -
Other names 3-<(1H-pyrrole-2-carbonyl)amino>propionic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:129053-84-5 SDS

129053-84-5Relevant articles and documents

Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors

Bhale, Nagesh A.,George, Joel,Godugu, Chandraiah,Kadagathur, Manasa,Kumar Sigalapalli, Dilep,Nagesh, Narayana,Panda, Biswajit,Phanindranath, Regur,Shankaraiah, Nagula,Sujat Shaikh, Arbaz,Tangellamudi, Neelima D.

, (2022/03/02)

A series of 17 indolo/pyrroloazepinone-oxindole conjugates was synthesized and evaluated for their antiproliferative activity against a panel of selected human cancer cell lines including A549 (lung cancer), HCT116 (colon cancer), MCF7 (breast cancer), and SK-MEL-28 (melanoma). Among the synthesized molecules (14a-m and 15a-d), compound 14d displayed remarkable activity against A549, HCT116 and SK-MEL-28 cells with IC50 values 50 value of 2.33 μM) over the normal rat kidney cells (NRK). Further, 14d-mediated apoptosis affected the cellular and nuclear morphology of the cancer cells in a dose-dependent manner. Wound healing and clonogenic assays inferred the inhibition of cell growth and migration. Target-based studies of compound 14d corroborated its DNA-intercalative capability and Topo I inhibitory activity which have been fortified by molecular modeling studies. Finally, the drug-likeness of the potent compound was determined by performing in silico ADME/T prediction studies.

Synthesis and antibacterial evaluation of (E)-1-(1H-indol-3-yl) ethanone O-benzyl oxime derivatives against MRSA and VRSA strains

Akunuri, Ravikumar,Veerareddy, Vaishnavi,Kaul, Grace,Akhir, Abdul,Unnissa, Tanveer,Parupalli, Ramulu,Madhavi,Chopra, Sidharth,Nanduri, Srinivas

supporting information, (2021/08/27)

Infections caused due to multidrug resistant organisms have emerged as a constant menace to human health. Even though numerous antibiotics are currently available for treating infectious diseases, a great number of bacterial strains have acquired resistance to many of them. Among these, infections caused due to Staphylococcus aureus are predominant in adult and paediatric population. Indole is a prominent chemical scaffold found in many pharmacologically active natural products and synthetic drugs. A number of oxime ether containing compounds have attracted attention of researchers owing to their interesting biological properties. Current work details the synthesis of indole containing oxime ether derivatives and their evaluation for antimicrobial activity against a panel of bacterial and mycobacterial strains. Synthesized compounds demonstrated good to moderate activity against drug-resistant S. aureus including resistant to vancomycin. Among all, compound 5h was found to possess potent activity against susceptible as well as MRSA and VRSA strains of S. aureus with MIC of 1 μg/mL and 2–4 μg/mL respectively. In addition, compound 5h was found to be non-toxic to Vero cells and exhibited good selectivity index of >40. Further, 5h, E-9a and E-9b possessed good biofilm inhibition against S. aureus. With these assuring biological properties, synthesized compounds could be potential prospective antimicrobial agents.

Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine

White, Alex W.,Carpenter, Nicholas,Lottin, Jerome R. P.,McClelland, Richard A.,Nicholson, Robert I.

, p. 246 - 253,8 (2012/12/11)

The tetrahydroazepinone pharmacophore is a component of many interesting compounds, including several marine natural products, with anti-cancer properties. The synthesis and biological evaluation of a novel series of pyrroloazepinone and indoloazepinone oximes is reported. These compounds showed promising growth inhibition activity against four human cancer cell lines but did not significantly inhibit the cell cycle regulator cyclin dependent kinase 2. The most active compounds in this series displayed improved anti-proliferative activity over the related synthetic indoloazepine kenpaullone. The structure activity relationships exhibited by the azepinone pharmacophore suggests several novel lead compounds for anti-cancer drug discovery.

Pyrrolo[2,3-c]azepine derivatives: A new class of potent protein tyrosine phosphatase 1B inhibitors

Xie, Jianwei,Tian, Jinying,Su, Li,Huang, Manna,Zhu, Xinhai,Ye, Fei,Wan, Yiqian

supporting information; scheme or table, p. 4306 - 4309 (2011/08/10)

A series of pyrrolo[2,3-c]azepine derivatives was designed, synthesized, and evaluated as a new class of inhibitors against protein tyrosine phosphatase 1B (PTP1B) in vitro. The results demonstrated that compounds bearing a biphenyl moiety were proved to

Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin

Tutino, Federico,Posteri, Helena,Borghi, Daniela,Quartieri, Francesca,Mongelli, Nicola,Papeo, Gianluca

experimental part, p. 2372 - 2376 (2009/07/18)

(Z)-Axinohydantoin and (Z)-debromoaxinohydantoin, two pyrrole-imidazole alkaloids isolated from different marine sponges, possess moderate activities in inhibiting the progress of the cell cycle at different phases. A stereoselective synthesis of both nat

WNT SIGNALING INHIBITORS, AND METHODS FOR MAKING AND USING THEM

-

Page/Page column 34-35, (2009/01/20)

The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell.

A new glycociamidine ring precursor: Syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (±)-endo-2-debromohymenialdisine

Papeo, Gianluca,Posteri, Helena,Borghi, Daniela,Varasi, Mario

, p. 5641 - 5644 (2007/10/03)

(Chemical Equation Presented) The synthesis of the C11H 5 marine sponge alkaloids, (Z)-hymenialdisine and (Z)-2-debromohymenialdisine, is described. A key step was the condensation between aldisine or its monobromo derivative and a n

Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity

Mizuno, Akira,Inomata, Norio,Miya, Mikiko,Kamei, Tomoe,Shibata, Makoto,Tatsuoka, Toshio,Yoshida, Maki,Takiguchi, Chikako,Miyazaki, Tomoko

, p. 246 - 256 (2007/10/03)

A series of 1-aminoalkyl-pyrrolo[2,3-c]azepin-8-one derivatives was synthesized and evaluated as α1 adrenergic and serotonin 2 (5-HT2) receptor antagonists, with the aim of finding a novel antihypertensive agent potently exhibiting b

Synthesis of pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene method

Cho, Hidetsura,Matsuki, Shinsuke,Mizuno, Akira,Annoura, Hirokazu,Tatsuoka, Toshio

, p. 87 - 91 (2007/10/03)

A highly convenient method for the synthesis of 2-substituted pyrrole derivatives 7a-c from pyrrole using phosgene was developed. Successively, 7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 1a and 6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 1b (aldisin) were synthesized by phosphorus pentoxide/methanesulfonate and polyphosphoric acid cyclization.

Total Syntheses of Hymenialdisine and Debromohymenialdisine: Stereospecific Construction of the 2-Amino-4-Oxo-2-Imidazolin-5(Z)-Disubstituted Ylidene Ring System

Annoura, Hirokazu,Tatsuoka, Toshio

, p. 413 - 416 (2007/10/02)

The first total synthesis of hymenialdisine (1a) and debromohymenialdisine (1b) was achieved via a novel stereospecific construction of the 2-amino-4-oxo-2-imidazoline-5(Z)-disubstituted ylidine ring system.

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