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CAS

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1303607-07-9

MI-773 is a pharmaceutical compound that functions as an inhibitor of the MDM2-p53 protein-protein interaction, which is a crucial regulatory mechanism in the cell cycle and tumor suppression. It is designed to target and disrupt the interaction between the MDM2 and p53 proteins, thereby stabilizing the p53 protein and enhancing its tumor-suppressive activity.

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  • (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

    Cas No: 1303607-07-9

  • USD $ 1.9-2.9 / Gram

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  • 1303607-07-9 Structure

  • Basic information

    1. Product Name: MI-773
    2. Synonyms: MI-773;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neop
    3. CAS NO:1303607-07-9
    4. Molecular Formula: C29H34Cl2FN3O3
    5. Molecular Weight: 562.5029632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1303607-07-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 732.1±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.36±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 12.03±0.70(Predicted)
    10. CAS DataBase Reference: MI-773(CAS DataBase Reference)
    11. NIST Chemistry Reference: MI-773(1303607-07-9)
    12. EPA Substance Registry System: MI-773(1303607-07-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1303607-07-9(Hazardous Substances Data)

1303607-07-9 Usage

Uses

Used in Pharmaceutical Industry:
MI-773 is used as an anticancer agent for its potential to treat various types of cancer by inhibiting the MDM2-p53 interaction. This action leads to the stabilization of the p53 protein, which in turn activates its tumor-suppressive functions and can result in the inhibition of tumor growth and progression.
Additionally, MI-773 is being investigated in clinical trials to further explore its efficacy and safety in cancer treatment. MI-773's ability to modulate the MDM2-p53 interaction may offer a promising therapeutic strategy for patients with cancer, particularly those with p53-dependent tumors.

Check Digit Verification of cas no

The CAS Registry Mumber 1303607-07-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,3,6,0 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1303607-07:
(9*1)+(8*3)+(7*0)+(6*3)+(5*6)+(4*0)+(3*7)+(2*0)+(1*7)=109
109 % 10 = 9
So 1303607-07-9 is a valid CAS Registry Number.

1303607-07-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

1.2 Other means of identification

Product number -
Other names MI-773

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1303607-07-9 SDS

1303607-07-9Relevant articles and documents

SPIRO-OXINDOLE MDM2 ANTAGONISTS

-

, (2011/05/16)

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

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