138116-34-4

Basic information

• Product Name: (4-AMINO-PYRIDIN-3-YL)-METHANOL
• Synonyms: RARECHEM AL BD 1386;4-AMINO-3-HYDROXYMETHYLPYRIDINE;4-AMINO-3-PYRIDINE METHANOL;(4-AMINO-PYRIDIN-3-YL)-METHANOL;4-AMINOPYRIDINE-3-METHANOL;3-Pyridinemethanol,4-amino-(9CI);3-AMINO-4-PYRIDINE METHANOL;4-Aminopyridine-3-methanol ,97%
• CAS NO: 138116-34-4
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 207-987-9
• Product Categories: PYRIDINE;pharmacetical;Pyridine series;Hydroxymethyl's;Pyridines
• Mol File: 138116-34-4.mol

Chemical Properties

• Melting Point: 167-169℃
• Boiling Point: 367.19 °C at 760 mmHg
• Flash Point: 175.871 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.54±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• Stability: Air Sensitive
• CAS DataBase Reference: (4-AMINO-PYRIDIN-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINO-PYRIDIN-3-YL)-METHANOL(138116-34-4)
• EPA Substance Registry System: (4-AMINO-PYRIDIN-3-YL)-METHANOL(138116-34-4)

Safety Data

• Hazard Codes: Xi,T+
• Statements: 28-36/37/38
• Safety Statements: 26-36/37/39-45-37
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: US1750000
• HazardClass: IRRITANT
• Hazardous Substances Data: 138116-34-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(4-AMINO-PYRIDIN-3-YL)-METHANOL is used as an organic chemical synthesis intermediate for the production of various chemical compounds. Its unique structure allows it to be a versatile building block in the creation of a wide range of molecules with diverse applications across different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-AMINO-PYRIDIN-3-YL)-METHANOL is used as a key intermediate in the synthesis of drugs with potential therapeutic applications. Its ability to form various molecular structures makes it a valuable component in the development of new medications.
Used in Research and Development:
(4-AMINO-PYRIDIN-3-YL)-METHANOL is also utilized in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its versatility as a chemical intermediate enables scientists to investigate its potential in creating new materials and substances with unique properties.
Used in Material Science:
In the field of material science, (4-AMINO-PYRIDIN-3-YL)-METHANOL can be employed as a component in the development of advanced materials with specific properties. Its role as a chemical intermediate allows for the creation of materials with tailored characteristics, such as improved strength, conductivity, or chemical resistance.

InChI:InChI=1/C6H8N2O/c7-6-1-2-8-3-5(6)4-9/h1-3,9H,4H2,(H2,7,8)

Upstream product

• 16135-36-7 methyl 4-aminonicotinate 
• 1003-73-2 3-picoline-N-oxide 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1078-05-3 4-nitro-3-carboxypyridine 1-oxide 
• 7418-65-7 4-aminonicotinic acid 
• 42373-30-8 4-aminonicotinaldehyde 
• 504-24-5 4-aminopyridine 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 86847-71-4 N-(3-formylpyridin-4-yl)-2,2-dimethylpropanamide 

Downstream Products

• 1026039-69-9 3-chloromethyl-pyridin-4-ylamine hydrochloride 
• 1421473-35-9 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-amine 
• 1421473-36-0 phenyl 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-ylcarbamate 
• 1421473-37-1 1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yl)-3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)urea 
• 1421473-31-5 1-(3-(hydroxymethyl)pyridin-4-yl)-3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)urea 
• 407623-72-7 tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate 
• 42373-30-8 4-aminonicotinaldehyde 
• 1330531-71-9 {4-[2-(2-fluoro-5-trifluoromethyl-phenyl)-[1,8]naphthyridin-4-ylamino]-pyridin-3-yl}-methanol 
• 177592-15-3 4-hydroxy-3-hydroxymethylpyridine 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heterocyclic Aza Compounds

Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.

Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines

Dioxaphosphorino[m,n-x]pyridines compounds have been prepared by condensation of methyl dichlorophosphate with new ortho-hydroxymethylpyridinols.