146368-11-8

Basic information

• Product Name: Cy5
• Synonyms: Cy 5 acid;2-[5-[1-(5-Carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadienyl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium inner salt;2-(5-(1-(5-Carboxypentyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate;Sulfo Cy5 Carboxylic acids(ethyl);Sulfo-Cy5-acid;Cy5-COOH
• CAS NO: 146368-11-8
• Molecular Formula: C₃₃H₄₀N₂O₈S₂
• Molecular Weight: 937.0428
• Mol File: 146368-11-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Cy5(CAS DataBase Reference)
• NIST Chemistry Reference: Cy5(146368-11-8)
• EPA Substance Registry System: Cy5(146368-11-8)

Safety Data

• Hazardous Substances Data: 146368-11-8(Hazardous Substances Data)

Usage

Uses

Used in Fluorescent Labeling Applications:
3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt is used as a fluorescent labeling agent for various biological and chemical applications. Its unique structure allows for specific binding and detection of target molecules, making it a valuable tool in research and diagnostics.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt can be used as a building block or intermediate for the synthesis of more complex molecules. Its versatile functional groups enable it to be further modified or incorporated into larger structures, potentially leading to new compounds with novel properties and applications.
Used in Pharmaceutical Research:
3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt may also have potential applications in the pharmaceutical industry. Its unique chemical structure could be exploited to develop new drugs or drug candidates, particularly for targeting specific biological pathways or receptors.
Used in Analytical Chemistry:
In analytical chemistry, 3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt can be employed as a reagent or probe for the detection and analysis of various compounds. Its fluorescent properties may be particularly useful in techniques such as fluorescence spectroscopy or microscopy.
Used in Material Science:
3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt may also find applications in the field of material science. Its unique structure and properties could be utilized in the development of new materials with specific characteristics, such as improved optical, electronic, or mechanical properties.
Used in Environmental Applications:
In environmental science, 3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt could be used for the detection and monitoring of pollutants or contaminants in various environmental samples. Its fluorescent properties may enable the development of sensitive and selective detection methods for a wide range of target analytes.
Used in Biomedical Research:
3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-

InChI:InChI=1/C45H52N4O14S2/c1-44(2)32-28-30(64(56,57)58)18-20-34(32)46(26-12-6-10-16-42(54)62-48-38(50)22-23-39(48)51)36(44)14-8-5-9-15-37-45(3,4)33-29-31(65(59,60)61)19-21-35(33)47(37)27-13-7-11-17-43(55)63-49-40(52)24-25-41(49)53/h5,8-9,14-15,18-21,28-29H,6-7,10-13,16-17,22-27H2,1-4H3,(H-,56,57,58,59,60,61)

Upstream product

• 146368-08-3 1-(5-carboxypentyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 146368-07-2 1-Ethyl-2,3,3-Trimethylindolenineninium 5-Sulfone 
• 4224-70-8 6-bromohexanoic acid 
• 51143-32-9 malonaldehyde bis(phenylimine) monohydrochloride 
• 146397-21-9 C₂₄H₂₆N₂O₄S 
• 98-71-5 4-hydrazino-benzenesulfonic acid 
• 563-80-4 3-methyl-butan-2-one 
• 132557-72-3 2,3,3-trimethylindole-5-sulfonic acid 

Downstream Products

• 917979-27-2 C₃₇H₄₃N₃O₁₀S₂ 
• 1246943-82-7 Cy₅-NHS 
• 1246943-82-7 Cy 5 
• 917979-27-2 3H-indolium-2-[(1E,3E,5E)-5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadienyl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt, succinimidyl ester 

Relevant articles and documents

FLUORESCENCE COMPOUNDS AND PREPARATION METHOD THEREOF

Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.

Cyanine compound for labeling biomolecule and preparation method thereof

Disclosed are a novel cyanine compound, represented by the following Formula 1, for labeling biomolecules, and a method for preparing the same. wherein R1, R2, R3, R4, B, m and n are defined as above.

Synthesis of PEG derivatives bearing aminophenyl and their application for liquid-phase synthesis of water-soluble unsymmetrical cyanine dyes

The synthesis and NMR characterization of soluble PEG-supported polymers were described, and their subsequent application for liquid-phase synthesis of water-soluble cyanine dyes was also studied. Nucleophilic substitution of tosylation of PEG 16 with 1,3-bis(4-nitrophenoxy)-2-propanol 15 under basic conditions, followed by nitro group reduction, gave PEG-bound aminophenyl 18. Another PEG-bound aminophenyl 28 was prepared by condensation reaction of PEG-bound pentaerythritol 25 and 4-aminobenzoic acid followed by the cleavage of BOC group. Subsequent loading and activation of sulfoindoleninium to PEG derivatives 18 or 28 were achieved via simple strategies. Cyanine dyes were released by the attack of heterocyclic carbon nucleophile and the cleavage of PEG-bound hemicyanine without the chromatographic separation. The efficient, facile, and practical approaches appear to be robust and versatile strategies to deliver not only indocyanine dyes but also benzoindocyanine dyes.

An efficient approach to the synthesis of water-soluble cyanine dyes using poly(ethylene glycol) as a soluble support

An efficient synthesis approach to unsymmetrical water-soluble cyanine dyes has been established. Loading and activation of sulfoindolenium to poly(ethylene glycol) (PEG) have been achieved via a simple strategy. Cyanine dyes are released by the attack of heterocyclic carbon nucleophile and the cleavage of PEG-bound hemicyanine. The efficient approach delivers cyanine dyes in high purity without the nontrivial chromatographic separation.

PH sensitive cyanine dyes as reactive fluorescent reagents

The present invention provides pH sensitive cyanine dyes having the structure (I) wherein X and Y are independently selected from >C(C1 - C4alkyl)2, sulfur and oxygen; R1 and R2 are independently selected from H, CH2NH2, SO3-, phosphate, phosphonate, quaternary ammonium, (CH2)qCOOH, NCS, CH2NH-COR7, where R7 is C1 - C20 straight or branched alkyl and (CH2)qCOOH where q is an integer from 0 - 10; R3 is H or -L-P where L is selected from C1 - C20 straight or branched alkyl optionally containing 0, 1 or 2 unsaturated groups selected from alkenyl and alkynyl, and P is selected from a reactive group, H, C1 - C20 straight or branched alkyl, SO3-, NH2, quaternary ammonium, CH2NH-COR8, where R8 is C1 - C20 straight or branched alkyl, -(CH2)mCOOH, NHR9 where R9 is C1 - C20 straight or branched alkyl; n is an integer from 0 - 3; p and r are independently 0, 1, 2, 3 or 4 and where p and/or r is greater than 1, each R1 and each R2 may be different, and m is an integer from 1 - 10; and salts and protonated derivatives thereof and methods of using same as fluorescent reagents.