149686-06-6

Basic information

• Product Name: 2-METHOXY-5-NITROFORMANILIDE
• Synonyms: 2-METHOXY-5-NITROFORMANILIDE;N-(2-Methoxy-5-nitrophenyl)forMaMide;NSC 99632
• CAS NO: 149686-06-6
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16012
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 149686-06-6.mol

Chemical Properties

• Appearance: /
• Solubility: DMSO, Ethanol, Ethyl Acetate, Methanol
• CAS DataBase Reference: 2-METHOXY-5-NITROFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-NITROFORMANILIDE(149686-06-6)
• EPA Substance Registry System: 2-METHOXY-5-NITROFORMANILIDE(149686-06-6)

Safety Data

• Hazardous Substances Data: 149686-06-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-METHOXY-5-NITROFORMANILIDE is used as an intermediate in the synthesis of various organic compounds for [application reason]. Its chemical structure allows it to participate in a range of reactions, making it a valuable component in the creation of diverse molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-METHOXY-5-NITROFORMANILIDE is used as a building block for the development of new drugs. Its unique properties enable it to be incorporated into the molecular structures of potential therapeutic agents, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
2-METHOXY-5-NITROFORMANILIDE is also employed in chemical research as a model compound to study various reaction mechanisms and to understand the behavior of similar compounds. This helps researchers in the development of new synthetic methods and the optimization of existing ones.
Used in Dye Industry:
In the dye industry, 2-METHOXY-5-NITROFORMANILIDE is used as a precursor for the synthesis of various dyes and pigments. Its yellow color and chemical reactivity make it a suitable candidate for the production of a range of colored compounds.
Used in Material Science:
2-METHOXY-5-NITROFORMANILIDE is utilized in material science for the development of novel materials with specific properties. Its incorporation into polymers and other materials can lead to the creation of materials with enhanced characteristics, such as improved stability or specific optical properties.

Upstream product

• 64-18-6 formic acid 
• 99-59-2 3-amino-4-methoxynitrobenzene 

Downstream Products

• 133706-80-6 5-Methoxy-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 107575-60-0 6-amino-5-methoxy-2-ethoxycarbonylindole 
• 119825-27-3 6-(Formylamino)-5-methoxyindol-2-carbonsaeure-ethylester 
• 107575-59-7 ethyl pyruvate 3-formamido-4-methoxyphenyl-hydrazone 
• 72909-34-3 pyrroloquinoline quinone 
• 80721-47-7 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 19871-39-7 N-methyl-2-methoxy-5-nitroaniline 
• 119825-21-7 3-Formylamino-4-methoxy-benzenediazonium; chloride 
• 78939-34-1 N-(5-amino-2-methoxylphenyl)formamide 
• 15999-35-6 5-Nitro-2-methoxy-phenyl-isocyaniddichlorid 

Relevant articles and documents

Pyrroloquinoline quinone synthetic method

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.

PYRROLOQUINOLINE QUINONE DISODIUM SALT CRYSTAL

Provided are pyrroloquinoline quinone disodium salt crystalline Forms A and B, and their preparation methods and uses. These crystalline forms have low moisture absorption and high stability, as well as excellent use and storage performances.

An eco-benign and highly efficient procedure for N-acylation catalyzed by heteropolyanion-based ionic liquids using carboxylic acid under solvent-free conditions

An eco-benign and highly efficient route for N-acylation of amines has been developed by treating amines with corresponding carboxylic acids in the presence of 2 mol % of heteropolyanion-based ionic liquids as catalysts under solvent-free conditions. This practical reaction could tolerate a wide range of substrates. Thus, various N-acylation products including N-acyl α-amino acid derivatives were obtained in moderate to excellent yields at 70 C to 120 C. Moreover, recycling studies revealed that heteropolyanion-based ionic liquids were easily reusable for this N-acylation. This method provides a green and much improved protocol over the existing methods.

SYNTHESIS OF PYRROLOQUINOLINE QUINONE (PQQ)

The invention relates to a novel nine step process for synthesizing PQQ (methoxatin). This process is efficient and reliably provides PQQ in excellent purity and high yield.

Preparation of PQQ in the kg Scale

The improvement of the PQQ synthesis according to the method of Corey and Tramontano allows the preparation of the triester of this cofactor in the kg scale with an overall yield of 13percent (average 78percent per step), without a bottleneck in the sequence and with crystalline, analytically pure intermediates.The new purification of free PQQ from conc.H2SO4 is remarkable with respect to the application as well as to the stability of this natural product.