150712-57-5

Basic information

• Product Name: 6-Hydroxy-2-methoxynaphthalene
• Synonyms: 6-Hydroxy-2-methoxynaphthalene
• CAS NO: 150712-57-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.1959
• Mol File: 150712-57-5.mol

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 185-186 °C(Press: 8 Torr)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• PKA: 9.43±0.40(Predicted)
• CAS DataBase Reference: 6-Hydroxy-2-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-2-methoxynaphthalene(150712-57-5)
• EPA Substance Registry System: 6-Hydroxy-2-methoxynaphthalene(150712-57-5)

Safety Data

• Hazardous Substances Data: 150712-57-5(Hazardous Substances Data)

Upstream product

• 575-44-0 1,6-dihydroxynaphthalene 
• 67-56-1 methanol 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 53473-35-1 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl acetate 
• 32940-15-1 5-methoxy-2-tetralone 
• 3900-49-0 1,6-dimethoxynaphthalene 

Downstream Products

• 1552320-92-9 2-[4-[[2-(5-methoxy-2-naphthyl)-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]amino]phenyl]acetic acid 
• 1552321-21-7 C₂₈H₂₇N₃O₅S 
• 105467-67-2 4-hydroxydibenzacridine 

Relevant articles and documents

Synthesis of β-nitro ketones from geminal bromonitroalkanes and silyl enol ethers by visible light photoredox catalysis

Various β-nitro ketones, including those bearing a β-tertiary carbon, were prepared from geminal bromonitroalkanes and trimethylsilyl enol ethers of a broad range of ketones by visible light photoredox catalysis, which were then easily converted into β-amino ketones, 1,3-amino alcohols, α,β-unsaturated ketones, β-cyano ketones and γ-nitro ketones.

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

Ene reductases (EREDs) have great potential as oxidation biocatalysts, as demonstrated by their efficient conversion of a number of tetralones to the corresponding naphthols. Of 96 enzymes tested, 57 were able to produce 2-naphthol in this way. Further tests with substituted tetralones revealed typically high conversions up to >99%. The reactions were performed under mild conditions in aqueous buffer with only co-solvent, biocatalyst and oxidation substrate required for conversion. Production of a methoxy-substituted naphthol was also successfully performed on a gram scale, with 91% yield. This methodology provides a new avenue to produce substituted naphthols as valuable building blocks, with the possibility to extend the approach to the production of phenols also being demonstrated.

Deleterious effect of 7-methyl group on glycosylation of 2-naphthols

C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (1). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-napht

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is W is a six-membered heterocyclic ring system having 1-2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring system having up to two nitrogen atoms within either or both rings, provided that no nitrogen is at a bridge of the bicyclic-six-six-fused-ring system, and further having 1-2 substitutents independently selected from R3. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat diseases or conditions in which α7 is known to be involved.

Regioselective Monomethylation of Unsymmetrical Naphthalenediols with Methanolic HCl

Treatment of naphthalene-1,3-diol and naphthalene-1,7-diol with methanol containing dry hydrogen chloride at room temperature gives exclusively 3-methoxy-1-naphthol and 7-methoxy-1-naphthol, respectively.Of the other two unsymmetrical naphthalenediols, the 1,2-isomer was unreactive and the 1,6-isomer gave a mixture of regioisomers under the same conditions.Two symmetrical diols (the 1,5- and 2,7-isomers) examined by the same procedure gave the monomethyl ethers in 60-70percent yields.