154456-97-0

Basic information

• Product Name: Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate
• Synonyms: Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate;2-benzyl 1-(tert-butyl) 4-oxopyrrolidine-1,2-dicarboxylate;(S)-4-Oxopyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester;N-(tert-butyloxycarbonyl)-4-oxoproline benzyl ester;(S)-2-benzyl1-tert-butyl4-oxopyrrolidine-1,2-dicarboxylate(WXC07842)
• CAS NO: 154456-97-0
• Molecular Formula: C₁₇H₂₁NO₅
• Molecular Weight: 319.36
• Mol File: 154456-97-0.mol

Chemical Properties

• Boiling Point: 439.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• PKA: -3.90±0.40(Predicted)
• CAS DataBase Reference: Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate(154456-97-0)
• EPA Substance Registry System: Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate(154456-97-0)

Safety Data

• Hazardous Substances Data: 154456-97-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate is used as a chiral building block for the synthesis of pharmaceuticals and biologically active molecules. Its unique structure and protecting group make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Benzyl (S)-1-Boc-4-oxo-2-pyrrolidinecarboxylate is also used as an intermediate in the synthesis of agrochemical products. Its versatility allows it to be incorporated into the development of various agrochemicals, contributing to advancements in agriculture and pest control.

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 
• 51-35-4 4R-4-hydroxyproline 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 89813-47-8 N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester 
• 100-39-0 benzyl bromide 
• 84348-37-8 N-tert-butoxycarbonyl-4-oxo-L-proline 

Downstream Products

• 84348-37-8 N-tert-butoxycarbonyl-4-oxo-L-proline 
• 249581-21-3 (1R,3R,5R,7S)-3-Benzoyl-8-oxo-6-aza-bicyclo[3.2.1]octane-6,7-dicarboxylic acid 7-benzyl ester 6-tert-butyl ester 
• 474417-78-2 benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate 
• 1283146-43-9 (2S,4S)-1-(tert-butoxycarbonyl)-4-ethylpyrrolidine-2-carboxylic acid 
• 1283147-26-1 (S)-2-benzyl 1-tert-butyl 4-ethylidenepyrrolidine-1,2-dicarboxylate 
• 497103-78-3 1-(tert-butoxycarbonyl)-4-(trifluoromethyl) pyrrolidine-2-carboxylic acid 
• 203866-15-3 1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline 

Relevant articles and documents

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Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

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ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

Practical synthesis of Boc-protected cis-4-trifluoromethyl and cis-4-difluoromethyl-L- prolines

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