155377-05-2

Basic information

• Product Name: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester
• Synonyms: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester ;methyl 6-(trifluoromethyl)picolinate;Methyl 2-(trifluoromethyl)-6-pyridinecarboxylate;Methyl 6-(trifluoroMethyl)pyridine-2-carboxylate;Methyl 6-trifluoroMethyl-2-pyridinecarboxylate;Enasidenib Intermediate 3
• CAS NO: 155377-05-2
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.14
• Mol File: 155377-05-2.mol

Chemical Properties

• Boiling Point: 232.6 °C at 760 mmHg
• Flash Point: 94.5 °C
• Appearance: /
• Density: 1.331 g/cm³
• Vapor Pressure: 0.0584mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.97±0.10(Predicted)
• CAS DataBase Reference: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester(155377-05-2)
• EPA Substance Registry System: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester(155377-05-2)

Safety Data

• Hazardous Substances Data: 155377-05-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester is used as a key intermediate compound in the synthesis of a series of substituted pyridines for the treatment of depression. Its unique chemical structure allows for the development of novel therapeutic agents that can potentially target specific neurotransmitter receptors or pathways involved in depression, offering new treatment options for patients suffering from this mental health condition.

InChI:InChI=1/C8H6F3NO2/c1-14-7(13)5-3-2-4-6(12-5)8(9,10)11/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 26218-75-7 methyl 6-Bromopicolinate 
• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 
• 849830-15-5 methyl 6-iodopyridine-2-carboxylate 
• 887583-52-0 6-(trifluoromethyl)pyridine-2-carbonitrile 

Downstream Products

• 476472-37-4 2-(4-fluoro-phenyl)-3-oxo-3-(6-trifluoromethyl-pyridin-2-yl)-propionitrile 
• 476472-46-5 2-(4-fluoro-phenyl)-1-(6-trifluoromethyl-pyridin-2-yl)-ethanone 
• 476473-39-9 1-[2-(4-Fluoro-phenyl)-1-(6-trifluoromethyl-pyridin-2-yl)-eth-(E)-ylideneamino]-pyrrolidin-2-one 
• 1192356-23-2 2-(6-trifluoromethyl-pyridin-2-yl)-propan-2-ol 
• 1446507-40-9 2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine 
• 1446507-38-5 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4-(1H,3H)-dione 
• 1446502-11-9 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol 
• 1446507-68-1 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine 
• 1338372-54-5 (4-fluorophenyl)(3-(6-(trifluoromethyl)pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone 
• 883037-22-7 6-(trifluoromethyl)pyridine-2-carbohydrazide 
• 1192356-25-4 1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamine 
• 1192356-27-6 1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamine hydrochloride 
• 1192355-99-9 (+/-)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-1-(4-difluoromethoxy-phenyl)-5-(2-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one 
• 1192356-26-5 1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamine 4-methylbenzenesulfonate 

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