15970-74-8

Basic information

• Product Name: 2-(4-METHOXYBENZOYL)FURAN
• Synonyms: 2-(4-METHOXYBENZOYL)FURAN;CHEMBRDG-BB 6597831;2-FURYL(4-METHOXYPHENYL)METHANONE;2-furyl(4-methoxyphenyl)methanone(SALTDATA: FREE)
• CAS NO: 15970-74-8
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol File: 15970-74-8.mol

Chemical Properties

• Boiling Point: 336.9°C at 760 mmHg
• Flash Point: 157.5°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 0.000109mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-(4-METHOXYBENZOYL)FURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYBENZOYL)FURAN(15970-74-8)
• EPA Substance Registry System: 2-(4-METHOXYBENZOYL)FURAN(15970-74-8)

Safety Data

• Hazardous Substances Data: 15970-74-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Methoxybenzoyl)furan is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(4-Methoxybenzoyl)furan is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Antioxidant Applications:
2-(4-Methoxybenzoyl)furan is employed as an antioxidant, leveraging its potential to combat oxidative stress and protect cells from damage, which is crucial in various health and industrial settings.
Used in Anti-Inflammatory Applications:
2-(4-METHOXYBENZOYL)FURAN is also used as an anti-inflammatory agent, capitalizing on its ability to reduce inflammation and related symptoms, beneficial in the treatment of various conditions in the medical field.
Used in Organic Compound Production:
2-(4-Methoxybenzoyl)furan serves as a vital intermediate in the production of other organic compounds, highlighting its importance in organic chemistry and the synthesis of a wide range of chemical products.

InChI:InChI=1/C12H10O3/c1-14-10-6-4-9(5-7-10)12(13)11-3-2-8-15-11/h2-8H,1H3

Upstream product

• 527-69-5 2-furancarbonyl chloride 
• 100-66-3 methoxybenzene 
• 4682-94-4 furan-2-yl(4-hydroxyphenyl)methanone 
• 77-78-1 dimethyl sulfate 
• 201230-82-2 carbon monoxide 
• 733-53-9 p-methoxyphenyl(phenyl)iodonium tetrafluoroborate 
• 118486-94-5 2-(tributylstannyl)furan 
• 110-00-9 furan 
• 100-07-2 4-methoxy-benzoyl chloride 
• 615-08-7 2-furoic anhydride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-09-4 4-methoxybenzoic acid 
• 93-99-2 benzoic acid phenyl ester 
• 108-95-2 phenol 

Downstream Products

• 36726-85-9 2-(4-methoxyphenyl)pyridin-3-ol 
• 15970-75-9 (4-Methoxyphenyl) 2-furyl ketoxime 
• 100518-86-3 (furan-2-yl)-(4-methoxyphenyl)-methanol 
• 111609-58-6 1-(4-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine 
• 136912-36-2 2-((4-methoxyphenyl)thiocarbonyl)furan 
• 860183-19-3 4-hydroxy-7-(4-methoxy-phenyl)-benzofuran-6-carboxylic acid 
• 1982-65-6 N-(4-methoxyphenyl)-2-furylamide 
• 1244620-40-3 N'-(furan-2-yl(4-methoxyphenyl)methylene)-4-methylbenzenesulfonohydrazide 
• 4682-94-4 furan-2-yl(4-hydroxyphenyl)methanone 

Relevant articles and documents

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An Electrophilic Approach to the Palladium-Catalyzed Carbonylative C-H Functionalization of Heterocycles

A palladium-catalyzed approach to intermolecular carbonylative C-H functionalization is described. This transformation is mediated by PtBu3-coordinated palladium catalyst and allows the derivatization of a diverse range of heterocycles, including pyrroles, indoles, imidazoles, benzoxazoles, and furans. Preliminary studies suggest that this reaction may proceed via the catalytic formation of highly electrophilic intermediates. Overall, this provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones using stable reagents (aryl iodides and CO) and without the typical need to exploit pre-metalated heterocycles in carbonylative coupling chemistry.

Synthesis and biological activities of new halophenols

A series of new halophenols were synthesized, and their structures were established on the basis of 1H, 13C NMR and mass spectral data. All of the prepared compounds were screened for their in vitro protein tyrosine kinase (PTK) and vascular smooth muscle cell (VSMC) proliferation inhibitory activity. Twelve halophenols showed significant PTK inhibitory activity, most of them exhibited stronger activities than that of genistein, a positive reference compound. Several halophenols also displayed moderate VSMC proliferation inhibitory activity, compound 8c showed higher activity than that of tetrandrine, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and discussed. The results provided a foundation for the action mechanism study and further structure optimization of the halophenols.

Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

Synthesis of arylketones by ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acids

The first ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acids is reported. Various aliphatic and aromatic aldehydes are transformed to the corresponding arylketones. A total of 31 examples with moderate to excellent yields are presented, together with the results of an initial mechanistic investigation.

Ligand-free Pd-catalyzed carbonylative cross-coupling reactions under atmospheric pressure of carbon monoxide: Synthesis of aryl ketones and heteroaromatic ketones

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