16027-16-0

Basic information

• Product Name: 7-Methoxy-isoquinolin-1(2H)-one
• Synonyms: 7-Methoxy-isoquinolin-1(2H)-one;7-Methoxy-2H-isoquinolin-1-one;7-METHOXY-1-ISOQUINOLINOL;7-methoxy-1(2H)-Isoquinolinone
• CAS NO: 16027-16-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.19
• EINECS: -0
• Mol File: 16027-16-0.mol

Chemical Properties

• Melting Point: 207-207.5 °C
• Boiling Point: 424.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.199±0.06 g/cm3(Predicted)
• PKA: 12.79±0.20(Predicted)
• CAS DataBase Reference: 7-Methoxy-isoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-isoquinolin-1(2H)-one(16027-16-0)
• EPA Substance Registry System: 7-Methoxy-isoquinolin-1(2H)-one(16027-16-0)

Safety Data

• Hazardous Substances Data: 16027-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
7-Methoxy-isoquinolin-1(2H)-one is used as a building block for the synthesis of various pharmaceuticals and organic compounds, leveraging its versatile chemical properties to create a range of therapeutic agents.
Used in Anti-inflammatory Applications:
In the medical field, 7-Methoxy-isoquinolin-1(2H)-one is used as an anti-inflammatory agent, helping to reduce inflammation which is a common factor in many diseases and conditions.
Used in Analgesic Applications:
7-Methoxy-isoquinolin-1(2H)-one is utilized as an analgesic agent, providing pain relief which is essential in the management of various types of pain.
Used in Neurodegenerative Disease Treatment:
7-Methoxy-isoquinolin-1(2H)-one is being investigated for its potential use in the treatment of neurodegenerative diseases, where its properties may help slow the progression of these conditions or alleviate associated symptoms.
Used in Antioxidant Applications:
As an antioxidant, 7-Methoxy-isoquinolin-1(2H)-one is used to protect cells from damage caused by free radicals, which can contribute to aging and various diseases.
Used in Research and Development:
7-Methoxy-isoquinolin-1(2H)-one is a subject of ongoing research in the fields of medicine and pharmaceutical development, where its potential applications and mechanisms of action are being explored to expand its use in therapeutic interventions.

Upstream product

• 108-05-4 vinyl acetate 
• 39989-39-4 7-methoxyisoquinoline 
• 146607-34-3 7-methoxyisoquinoline 2-oxide 
• 1711-05-3 m-anisoyl chloride 
• 586-38-9 3-Methoxybenzoic acid 
• 1414350-91-6 3-methoxy-N-(pivaloyloxy)benzamide 
• 99848-43-8 2-bromo-5-methoxybenzamide 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 34014-47-6 7-methoxy-1-oxo-1H-isochromene-4-carboxylic acid 
• 131002-08-9 2-ethenyl-5-methoxybenzamide 
• 101033-24-3 4-methoxycinnamyl isocyanate 
• 412339-47-0 2-(4-methoxy-2-methoxycarbonyl-phenyl)-3-oxo-propionic acid methyl ester 
• 34014-48-7 methyl 7-methoxy-1-oxo-1H-isochromene-4-carboxylate 

Downstream Products

• 1432725-86-4 (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)methanone 
• 952569-54-9 1-iodo-7-methoxyisoquinoline 
• 1432725-84-2 (2-bromo-4,5-dimethoxyphenyl)(7-methoxyisoquinolin-1-yl)methanone 
• 1432725-83-1 (2-bromophenyl)(7-methoxyisoquinolin-1-yl)methanone 
• 1432725-69-3 (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile 
• 1432725-67-1 (2-bromo-4,5-dimethoxyphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile 
• 1432725-66-0 (2-bromophenyl)(7-methoxyisoquinolin-1-yl)acetonitrile 
• 53533-54-3 1-chloro-7-methoxy-isoquinoline 
• 110192-19-3 7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 444898-45-7 C₃₆H₂₉NO₉ 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 

Relevant articles and documents

Ruthenium(II)-Catalyzed C?H Activation/Annulation of Aromatic Hydroxamic Acid Esters with Enamides Leading to Aminal Motifs

Hydroxamic acid ester directed C(sp2)?H activation/annulation strategy has been reported employing electron-rich enamides under Ru(II)-catalysis to access aminal frameworks. Both N-vinyl acetamide and N-vinyl formamide delivered aminals bearing

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.

Quinazolinone and isoquinolinone derivative

The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent

The behavior of electron-rich alkenes in rhodium-catalyzed C-H activation/annulation reactions is investigated. Vinyl acetate emerges as a convenient acetylene equivalent, facilitating the synthesis of sixteen 3,4-unsubstituted isoquinolones, as well as select heteroaryl-fused pyridones. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

Palladium-catalyzed Synthesis of Isocoumarin and 1-Isoquinolinone Derivatives

In the presence of copper(I) chloride, the palladium catalyzed oxidation of methyl 2-ethenylbenzoates and 2-ethenylbenzamides have been studied.This reaction was used to form isocoumarins and 1-isoquinolinones.

The Preparation and Oxidative Dimerisation of 2-Acetyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline. A New Approach to Tetrahydroisoquinoline Synthesis

The title compound has been prepared from 1,2,3,4-tetrahydroisoquinoline via successive nitration, acetylation, reduction and diazotisation.Earlier conflicting reports on the nitration of tetrahydroisoquinoline have been clarified.A better synthetic route