Welcome to LookChem.com Sign In|Join Free

CAS

  • or
N-Succinimidyl-N-methylcarbamate is an organic compound that serves as a reagent in the synthesis of various pharmaceutical compounds. It is known for its role in the production of chemotherapeutic agents and other bioactive molecules.

18342-66-0 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 18342-66-0 Structure
  • Basic information

    1. Product Name: N-Succinimidyl-N-methylcarbamate
    2. Synonyms: 2,5-PYRROLIDINEDIONE, 1-[[(METHYLAMINO)CARBONYL]OXY]-;N-SUCCINIMDYL-N-METHYLCARBAMATE;N-SUCCINIMIDYL-N-METHYLCARBAMATE;N-Succinimidyl-N-methylcarbama;methyl isocyanate substitute;Methyl isocyanate substitute, MIC substitute;2,5-dioxopyrrolidin-1-yl MethylcarbaMate;SuO-NM
    3. CAS NO:18342-66-0
    4. Molecular Formula: C6H8N2O4
    5. Molecular Weight: 172.14
    6. EINECS: N/A
    7. Product Categories: Medical Intermediates;Norbornene Derivatives
    8. Mol File: 18342-66-0.mol
  • Chemical Properties

    1. Melting Point: 148-153 °C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /Solid
    5. Density: 1.416 g/cm3
    6. Refractive Index: 1.527
    7. Storage Temp.: 2-8°C
    8. Solubility: Dichloromethane (Slightly), DMSO (Slightly)
    9. PKA: 11.00±0.46(Predicted)
    10. Water Solubility: Slightly soluble in water.
    11. Sensitive: Moisture Sensitive
    12. BRN: 1531863
    13. CAS DataBase Reference: N-Succinimidyl-N-methylcarbamate(CAS DataBase Reference)
    14. NIST Chemistry Reference: N-Succinimidyl-N-methylcarbamate(18342-66-0)
    15. EPA Substance Registry System: N-Succinimidyl-N-methylcarbamate(18342-66-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. F: 10-21
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 18342-66-0(Hazardous Substances Data)

18342-66-0 Usage

Uses

Used in Pharmaceutical Synthesis:
N-Succinimidyl-N-methylcarbamate is used as a reagent for the synthesis of Argifin, a natural product chitinase inhibitor with chemotherapeutic potential. It plays a crucial role in the development of this compound, which may have applications in cancer treatment.
Used in the Preparation of A616300:
N-Succinimidyl-N-methylcarbamate is also used as a reagent in the preparation of 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide (A616300), a metabolite of Temozolomide (T017775). Temozolomide is an imidazotetrazine alkylating agent and antineoplastic, which means it has cancer-fighting properties. The use of N-Succinimidyl-N-methylcarbamate in the synthesis of A616300 contributes to the development of this potent chemotherapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 18342-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,4 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18342-66:
(7*1)+(6*8)+(5*3)+(4*4)+(3*2)+(2*6)+(1*6)=110
110 % 10 = 0
So 18342-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O4/c1-7-6(11)12-8-4(9)2-3-5(8)10/h2-3H2,1H3,(H,7,11)

18342-66-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H63566)  N-Succinimidyl N-methylcarbamate, 97%   

  • 18342-66-0

  • 1g

  • 276.0CNY

  • Detail
  • Alfa Aesar

  • (H63566)  N-Succinimidyl N-methylcarbamate, 97%   

  • 18342-66-0

  • 5g

  • 728.0CNY

  • Detail
  • Alfa Aesar

  • (H63566)  N-Succinimidyl N-methylcarbamate, 97%   

  • 18342-66-0

  • 25g

  • 2594.0CNY

  • Detail
  • Aldrich

  • (66181)  N-SuccinimidylN-methylcarbamate  ≥97.0% (N)

  • 18342-66-0

  • 66181-5G

  • 1,064.70CNY

  • Detail
  • Aldrich

  • (66181)  N-SuccinimidylN-methylcarbamate  ≥97.0% (N)

  • 18342-66-0

  • 66181-25G

  • 3,495.96CNY

  • Detail

18342-66-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,5-dioxopyrrolidin-1-yl) N-methylcarbamate

1.2 Other means of identification

Product number -
Other names O-succinimidyl N-methylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18342-66-0 SDS

18342-66-0Relevant articles and documents

Synthesis and in vitro antitumor activity of novel 2-alkyl-5- methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives

Mori, Ryota,Kato, Asako,Komenoi, Kousuke,Kurasaki, Haruaki,Iijima, Touru,Kawagoshi, Masashi,Kiran,Takeda, Sho,Sakai, Norio,Konakahara, Takeo

, p. 16 - 35 (2014/06/09)

Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.

Preparation and screening against acetylcholinesterase of a non-peptide "indexed" combinatorial library

Pirrung, Michael C.,Chen, Jrlung

, p. 1240 - 1245 (2007/10/02)

A combinatorial library composed from nine alcohols and six isocyanates to formally generate 54 carbamates has been designed prepared, and screened against acetylcholinesterase from the electric eel. In order to deduce the most active member of the library, it was prepared as 15 sublibraries in which one of the reacting components was fixed and the other reactants were used as an equimolar mixture. The product mixtures were tested and their activities used as "indices" to the rows or columns of a two-dimensional matrix reflecting the activities of individual carbamates. A number of carbamates in the most active row and column were synthesized and assayed, demonstrating that the most active cell in the matrix could be identified by the sublibrary synthesis procedure. Other methods for generating large libraries of molecules for biological screening that have recently been developed have relied on a covalent attachment between library members and a label to identify the active components. Indexed libraries otter the advantage that they can be prepared from any class of compounds composed from multiple subunits and that any type of assay (binding, enzyme inhibition, agonism/antagonism, cell-based, or even whole organism assays for biological activity) can be used because all compounds are generated in a free form.

A convenient method for the synthesis of activated N-methylcarbamates

Konakahara,Ozaki,Sato,Gold

, p. 103 - 106 (2007/10/02)

An investigation of methods to efficiently prepare activated N-methylcarbamates is reported. N-(Methylcarbamoyloxy)succinimide (3a), aryl N-methylcarbamates 3b-d and 2,2,2-trifluoro-1-(trifluoromethyl)ethyl N-methylcarbamate (3e) have been prepared in 70-80% yields from the corresponding chloroformates 5a-e, which were prepared as crystalline solids by the condensation of trichloromethylchloroformate (1) or bis(trichloromethyl)carbonate (2) with hydroxy compounds 4a-e in high yields.

Convenient Methods for Syntheses of Active Carbamates, Ureas and Nitrosoureas Using N,N'-disuccinimido Carbonate (DSC)

Takeda, Kazuyoshi,Akagi, Yoshie,Saiki, Atsuko,Tsukahara, Toshiko,Ogura, Haruo

, p. 4569 - 4572 (2007/10/02)

The reaction of DSC and amino compounds afforded the corresponding carbamates which were able to be converted into ureas and nitrosoureas.

Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas

Martinez, Jean,Oiry, Joel,Imbach, Jean Louis,Winternitz, Francois

, p. 178 - 182 (2007/10/02)

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.

Dicarboximido-N-phenylsubstituted carbamates and derivatives

-

, (2008/06/13)

The Dicarboximido-N-Monosubstituted Carbamates of this invention are pesticidally active and particularly useful as herbicides.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 18342-66-0