18362-30-6

Basic information

• Product Name: 2-CHLORO-6-HYDROXYBENZALDEHYDE
• Synonyms: 2-chloro-6-hydroxy-benzaldehyd;6-CHLOROSALICYLALDEHYDE;2-CHLORO-6-HYDROXYBENZALDEHYDE;6-chloro salicyaldehyde;6-chloro salicyaldehyde 2-chloro-6-hydroxybenzaldehyde;6-Chlorosalicylaldehyde, 3-Chloro-2-formylphenol;Benzaldehyde, 2-chloro-6-hydroxy-
• CAS NO: 18362-30-6
• Molecular Formula: C₇H₅ClO₂
• Molecular Weight: 156.57
• Mol File: 18362-30-6.mol

Chemical Properties

• Melting Point: 51-55℃
• Boiling Point: 223.1 °C at 760 mmHg
• Flash Point: 107℃
• Appearance: /
• Density: 1.404 g/cm³
• Vapor Pressure: 0.0657mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: 2-8°C
• PKA: 7.21±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-HYDROXYBENZALDEHYDE(18362-30-6)
• EPA Substance Registry System: 2-CHLORO-6-HYDROXYBENZALDEHYDE(18362-30-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 18362-30-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-CHLORO-6-HYDROXYBENZALDEHYDE is used as a precursor or intermediate for the synthesis of more complex molecules. Its reactivity and structural features make it a valuable component in the creation of advanced organic compounds.
Used in Research and Development:
2-CHLORO-6-HYDROXYBENZALDEHYDE is used as a research compound for studying its properties and potential applications. Its slight solubility in water and ability to form crystals are of particular interest in scientific investigations.
Used in Pharmaceutical Industry:
2-CHLORO-6-HYDROXYBENZALDEHYDE is used as a building block in the development of pharmaceuticals. Its reactivity allows for the creation of new drug candidates with potential therapeutic applications.
Used in Chemical Industry:
2-CHLORO-6-HYDROXYBENZALDEHYDE is used as a chemical intermediate in the production of various industrial chemicals. Its versatility in chemical reactions contributes to its utility in this sector.

InChI:InChI=1/C7H5ClO2/c8-6-2-1-3-7(10)5(6)4-9/h1-4,10H

Upstream product

• 29866-54-4 2-chloro-6-methoxybenzaldehyde 
• 53600-33-2 6-methoxyanthranilic acid 
• 54166-96-0 methyl 2-amino-6-methoxybenzoate 
• 1038726-89-4 2-chloro-6-methoxyphenylmethanol 
• 936479-46-8 methyl 6-chloro-2-methoxybenzoate 
• 89-98-5 2-chloro-benzaldehyde 
• 50-00-0 formaldehyd 
• 108-43-0 3-monochlorophenol 
• 67-66-3 chloroform 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 3260-87-5 3-chloro-o-cresol 

Downstream Products

• 70384-83-7 5-chloro-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester 
• 221349-12-8 C₂₃H₂₅ClO₄ 
• 1267362-26-4 (E)-ethyl 3-(2-hydroxy-6-chlorophenyl)acrylate 
• 1235716-59-2 4-chlorobenzoic acid [1-(2-chloro-6-hydroxyphenyl)-methylidene]-hydrazide 
• 1616385-26-2 C₂₆H₃₄Cl₂N₂O₂ 
• 1154740-80-3 6-chloro-2H-chromene-3(4H)-one 
• 1352639-30-5 (S)-2-(8-chloro-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-3-cyclohexyl-N-thiazol-2-yl-propionamide 
• 1352639-25-8 (S)-2-(8-chloro-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-3-cyclohexyl-N-pyridin-2-ylpropionamide 
• 1352639-29-2 (S)-2-(8-chloro-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-3-cyclohexyl-propionic acid 
• 1352639-28-1 2-(8-chloro-3-oxo-3,3a-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-(3S)-3-cyclohexyl-propionic acid methyl ester 
• 1352639-27-0 5-chloro-3-[((S)-2-cyclohexyl-1-methoxycarbonyl-ethylamino)-methyl]-2H-chromene-2-carboxylic acid ethyl ester 
• 38226-05-0 2-chloro-6-hydroxy-3-nitro-benzaldehyde 
• 38225-98-8 6-Chlor-3-nitrosalicylaldehyd 
• 159194-03-3 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(3-chloro-2-formyl-phenoxy)-tetrahydro-pyran-3-yl ester 

Relevant articles and documents

Resolution of 2,3-dihydro-benzofuran-3-ols

A new method for the preparation of enantiopure 2,2-disubstituted 2,3-dihydro-benzofuran-3-ols is described. A short synthesis is designed for obtaining various 2,2-disubstitued benzofuran-3-ols as racemic mixtures of the two possible syn and anti diastereoisomers, which can be separated after silylation. The major racemic anti isomers were transesterified using (R) -pentolactone, allowing separation of the pure enantiomers. Indian Academy of Sciences.

METHOD FOR PREPARING 3-SUBSTITUTED 2-VINYLPHENYL SULFONATES

The present invention relates to a method for preparing 3-substituted 2-vinylphenyl sulfonates.

A Strategy toward Icetexane Natural Products

Icetexane diterpenoids are richly complex polycyclic natural products that have been described with a variety of biological activities. We report here a general synthetic approach toward the 6-7-6 tricyclic core structure of these interesting synthetic ta

PROCESS FOR PREPARING 3-CHLORO-2-VINYLPHENYLSULFONATES

The present invention relates to a new process for preparing 3-chloro-2-vinylphenylsulfonate derivatives.

Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group

The direct Pd-catalyzed ortho C-H hydroxylation of benzaldehydes was achieved using 4-chloroanthranilic acid as the transient directing group, 1-fluoro-2,4,6-trimethylpyridnium triflate as the bystanding oxidant, and p-toluenesulfonic acid as the putative oxygen nucleophile. The unusual C-H chlorination and polyfluoroalkoxylation reactions signaled the importance of external nucleophiles to the outcome of Pd(IV) reductive eliminations.

Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE

The present invention relates to a compound of formula (I), and to pharmaceutical compositions containing said compound and to the use of said compound in therapy, for instance in treating cognitive disorders, as well as to intermediates useful in the preparation thereof.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.