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TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE is a carbamate derivative with the molecular formula C13H19N3O3. It is a chemical compound that serves as a pharmaceutical intermediate and is utilized in the synthesis of organic compounds. Characterized by a tert-butyl group, a pyridyl group, and a methoxy group, this compound plays a significant role in the development of new medications and pesticides. Its potential biological activities also make it a promising candidate in the fields of medicinal and agricultural chemistry.

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  • 183741-80-2 Structure
  • Basic information

    1. Product Name: TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE
    2. Synonyms: TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE;(6-Methoxy-3-pyridinyl)-carbamic acid 1,1-dimethylethyl ester;tert-Butyl N-(6-methoxypyridin-3-yl)carbamate;(6-Methoxy-pyridin-3-yl)-carbaMic acid tert-butyl ester;tert-butyl 6-Methoxypyridin-3-ylcarbaMate;3-(Boc-amino)-6-methoxypyridine;tert-Butyl (6-methoxypyridin-3-yl)
    3. CAS NO:183741-80-2
    4. Molecular Formula: C11H16N2O3
    5. Molecular Weight: 224.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 183741-80-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 278.6℃
    3. Flash Point: 122.3℃
    4. Appearance: /
    5. Density: 1.146
    6. Vapor Pressure: 0.00422mmHg at 25°C
    7. Refractive Index: 1.534
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE(183741-80-2)
    12. EPA Substance Registry System: TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE(183741-80-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 183741-80-2(Hazardous Substances Data)

183741-80-2 Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE is used as a pharmaceutical intermediate for the manufacturing of various drugs. Its unique structure, including the tert-butyl, pyridyl, and methoxy groups, contributes to the development of novel medications with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE is employed in the synthesis of pesticides. Its chemical properties allow for the creation of effective pest control agents, enhancing crop protection and contributing to increased agricultural productivity.
Used in Medicinal Chemistry Research:
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE is utilized as a key compound in medicinal chemistry research. Its potential biological activities and structural features make it a valuable tool for exploring new drug targets and developing innovative therapeutic agents.
Used in Agricultural Chemistry Research:
This chemical compound also finds application in agricultural chemistry research. Its properties can be harnessed to design and develop new pesticides with enhanced efficacy and selectivity, improving crop protection strategies and contributing to sustainable agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 183741-80-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,7,4 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 183741-80:
(8*1)+(7*8)+(6*3)+(5*7)+(4*4)+(3*1)+(2*8)+(1*0)=152
152 % 10 = 2
So 183741-80-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O3/c1-11(2,3)16-10(14)13-8-5-6-9(15-4)12-7-8/h5-7H,1-4H3,(H,13,14)

183741-80-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(6-methoxypyridin-3-yl)carbamate

1.2 Other means of identification

Product number -
Other names tert-Butyl-N-(6-methoxy-3-pyridyl)carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:183741-80-2 SDS

183741-80-2Relevant articles and documents

ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF

-

Paragraph 0613, (2019/03/17)

Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Gazzard, Lewis,Williams, Karen,Chen, Huifen,Axford, Lorraine,Blackwood, Elizabeth,Burton, Brenda,Chapman, Kerry,Crackett, Peter,Drobnick, Joy,Ellwood, Charles,Epler, Jennifer,Flagella, Michael,Gancia, Emanuela,Gill, Matthew,Goodacre, Simon,Halladay, Jason,Hewitt, Joanne,Hunt, Hazel,Kintz, Samuel,Lyssikatos, Joseph,Macleod, Calum,Major, Sarah,Médard, Guillaume,Narukulla, Raman,Ramiscal, Judi,Schmidt, Stephen,Seward, Eileen,Wiesmann, Christian,Wu, Ping,Yee, Sharon,Yen, Ivana,Malek, Shiva

, p. 5053 - 5074 (2015/07/02)

Checkpoint kinase 1 (ChK1) plays a key role in the DNA damage response, facilitating cell-cycle arrest to provide sufficient time for lesion repair. This leads to the hypothesis that inhibition of ChK1 might enhance the effectiveness of DNA-damaging therapies in the treatment of cancer. Lead compound 1 (GNE-783), the prototype of the 1,7-diazacarbazole class of ChK1 inhibitors, was found to be a highly potent inhibitor of acetylcholine esterase (AChE) and unsuitable for development. A campaign of analogue synthesis established SAR delineating ChK1 and AChE activities and allowing identification of new leads with improved profiles. In silico docking using a model of AChE permitted rationalization of the observed SAR. Compounds 19 (GNE-900) and 30 (GNE-145) were identified as selective, orally bioavailable ChK1 inhibitors offering excellent in vitro potency with significantly reduced AChE activity. In combination with gemcitabine, these compounds demonstrate an in vivo pharmacodynamic effect and are efficacious in a mouse p53 mutant xenograft model.

Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors

Han, Fangbin,Lin, Songwen,Liu, Peng,Liu, Xiujie,Tao, Jing,Deng, Xiaobing,Yi, Chongqin,Xu, Heng

supporting information, p. 434 - 438 (2015/04/27)

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway provides a promising new approach for cancer therapy. Through a rational design, a novel series of thienopyrimidine was discovered as highly pote

TRPV4 ANTAGONISTS

-

Page/Page column 78-79, (2013/03/26)

The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.

AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME

-

Page/Page column 46, (2011/08/04)

The invention relates to novel azacarbonlines having formula (I), wherein: R3, R4 represent independently H; hal; CF3; substituted oxy, optionally substituted alkoxy; optionally substituted amino; substituted carbonyl; optionally substituted carboxyl; optionally substituted amide; sulphur, such as optionally substituted sulphones, sulphoxides or sulphides; linear, branched or cyclic C1-C10 alkyl optionally comprising an optionally substituted heteroatom; optionally substituted linear, branched or cyclic C2-C7 alkenyl; optionally substituted linear or branched C2-C6 alkynyl; optionally substituted aryl or heteroaryl; of which may be optionally substituted; in the form of a base or an acid addition salt. The invention also relates to the use of same in therapeutics for the treatment of cancer and to synthesis methods.

Preparation of azaindolines and benzoyl substituted azaindolines: Precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

Badland, Matthew,Devillers, Ingrid,Durand, Corinne,Fasquelle, Véronique,Gaudillire, Bernard,Jacobelli, Henry,Manage, Ajith C.,Pevet, Isabelle,Puaud, Jocelyne,Shorter, Anthony J.,Wrigglesworth, Roger

supporting information; experimental part, p. 5292 - 5296 (2011/10/30)

The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors.

ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES

-

Page/Page column 73-74, (2009/03/07)

Azaindoles and diazaindoles having aromatic substituents on the 5-membered ring are agonists or partial agonists of the PPAR receptor and are useful in the treatment and control of type 2 diabetes and of symptoms of diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Azabenzodiazepines as pde4 inhibitors

-

Page/Page column 8, (2010/02/11)

Compounds of formula (I): characterized in that:R1 represents a group selected from hydrogen atom, methyl, methoxy, hydroxy, amino, dimethylamino, acetamido, pyrrolidin-1-yl, and hydroxymethyl;R2 represent a group selected from phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, indolyl, pyrolyl, [1,2,3]-triazolyl, benzo[c]isoxazolyl, thienyl, pyrazolyl, isothiazolyl, imidazolyl, benzofuranyl, pyrazolo[5,1-c][1,2,4]triazyl each of these groups being optionally substituted from 1 to 3 groups, identical or different independently of each other, selected from halogen, trifluoromethyl, (C1-C4)alkyl, (C1-C4)alkoxy, hydroxy, amino, acetamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acetylmethoxy, cyclopentyloxy; optionally, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as active ingredient in pharmaceutical composition useful for treating diseases involving therapy by inhibition of PDE4.

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Rewcastle, Gordon W.,Denny, William A.,Winters, R. Thomas,Colbry, Norman L.,Showalter, H. D. Hollis

, p. 2221 - 2226 (2007/10/03)

Directed lithiation of Boc or pivaloyl derivatives of 2-substituted 5-aminopyridines with BuLi-TMEDA in diethyl ether at -10°C gave 4-lithio derivatives which were quenched with CO2 to give the analogous C-4 carboxylic acids. Hydrolysis of the protecting groups with either TFA or aqueous KOH gave 2-substituted 5-aminopyridine-4-carboxylic acids which were converted to 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones by reaction with formamide or, more optimally, formamidine acetate. Boc protected aminopyridines provided the best overall results, with synthesis of these derivatives best achieved by direct reaction of the aminopyridine with di-tert-butyl dicarbonate in the absence of added base.

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