19284-81-2

Basic information

• Product Name: 2-AMINO-2'-NITRO DIPHENYL SULFIDE
• Synonyms: 2-AMINOPHENYL 2-NITROPHENYL SULFIDE;2-AMINO-2'-NITRO DIPHENYL SULFIDE;2-AMINO-2'-NITRODIPHENYL THIOETHER;2-(2-NITROPHENYLTHIO)ANILINE;2-AMINO-2''-NITRO DIPHENYL SULFIDE 99%MIN;o-(o-Nitrophenylthio)aniline;2-AMINO-2'-NITRO DIP;2-(2-Nitrophenylthio)aniline 2-Aminophenyl 2-Nitrophenyl Sulfide
• CAS NO: 19284-81-2
• Molecular Formula: C₁₂H₁₀N₂O₂S
• Molecular Weight: 246.29
• Product Categories: Amines
• Mol File: 19284-81-2.mol

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 375.325 °C at 760 mmHg
• Flash Point: 180.79 °C
• Appearance: /
• Density: 1.372 g/cm³
• PKA: 2.67±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-2'-NITRO DIPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2'-NITRO DIPHENYL SULFIDE(19284-81-2)
• EPA Substance Registry System: 2-AMINO-2'-NITRO DIPHENYL SULFIDE(19284-81-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 19284-81-2(Hazardous Substances Data)

Usage

Uses

Used in Dye and Pigment Manufacturing:
2-AMINO-2'-NITRO DIPHENYL SULFIDE is used as a key intermediate in the production of dyes and pigments, contributing to the development of colorants for various applications, such as textiles, plastics, and printing inks.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-AMINO-2'-NITRO DIPHENYL SULFIDE serves as a building block for the synthesis of various medicinal compounds, playing a crucial role in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
2-AMINO-2'-NITRO DIPHENYL SULFIDE is utilized as a versatile reagent in organic synthesis, enabling the formation of a wide range of organic compounds through chemical reactions, which can be further used in various industries.
Used as a Reagent in Chemical Reactions:
2-AMINO-2'-NITRO DIPHENYL SULFIDE is employed as a reagent in various chemical reactions, facilitating the synthesis of target molecules and contributing to the advancement of chemical research and development.

Upstream product

• 4837-33-6 o-nitrobenzenesulfenanilide 
• 88-73-3 2-Chloronitrobenzene 
• 137-07-5 2-amino-benzenethiol 
• 62-53-3 aniline 
• 4837-32-5 S-(2-nitrophenyl)-N-(p-tolyl)thiohydroxylamine 
• 609-73-4 o-nitroiodobenzene 
• 1141-88-4 2-Aminophenyl disulfide 
• 528-29-0 1,2-Dinitrobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 22100-66-9 bis-(2-nitro-phenyl)-sulfide 

Downstream Products

• 33253-01-9 (2-chloro-phenyl)-(2-nitro-phenyl)-sulfane 
• 3426-24-2 (2-iodo-phenyl)-(2-nitro-phenyl)-sulfide 
• 70787-32-5 2-bromophenyl(2-nitrophenyl)sulfane 
• 5873-51-8 2,2'-thiodianiline 
• 107920-28-5 acetic acid-[2-(2-nitro-phenylsulfanyl)-anilide] 
• 33224-08-7 N-methyl-2-(2-nitro-phenylsulfanyl)-aniline 
• 20912-11-2 2-((2-nitrophenyl)thio)phenol 
• 188058-54-0 Pentanedioic acid bis-{[2-(2-nitro-phenylsulfanyl)-phenyl]-amide} 
• 188058-72-2 3-(4-Methyl-piperazin-1-yl)-N-(2-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-propionamide 
• 188058-57-3 Pentanedioic acid bis-{[2-(2-amino-phenylsulfanyl)-phenyl]-amide} 
• 188058-63-1 Pentanedioic acid bis-({2-[2-(3-dimethylamino-propionylamino)-phenylsulfanyl]-phenyl}-amide) 
• 188058-60-8 Pentanedioic acid bis-[(2-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide] 
• 57106-90-8 2-hydroxy-2,4'-'dinitrodiphenyl sulphide 
• 861572-20-5 2-methylthio-2',4'-dinitrodiphenylamine 

Relevant articles and documents

Synthesis and Characterization of Metal Complexes of a New Unsymmetrical Tridentate NNS Schiff Base Ligand: X-ray Crystal Structure Determination of Nickel(II) Complex

A new unsymmetrical tridentate NNS Schiff base ligand, 2-(2-nitrophenylthio)-N-((pyridine-2-yl)methylene)benzenamine (L), and its Mn(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized. These compounds were characterized by different physicochemica

Synthesis and characterization of metal complexes with NOS unsymmetrical tridentate Schiff base ligand. X-ray crystal structures determination of nickel(II) and copper(II) complexes

A unsymmetrical tridentate NOS Schiff base ligand, 2-((2-(2-nitrophenylthio)phenylimino)methyl)phenol (HL) and its Mn(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes have been synthesized. These compounds have been characterized by different physico-chem

Metal complexes with thioether containing unsymmetrical N2S donor Schiff base ligand: Crystal and molecular structure of nickel(II) complex

A thioether unsymmetrical N2S donor Schiff base ligand, N-2-((2-nitrophenyl)thio)phenyl)-1-(pyrrole-2-yl)methanimine (HL) and its five complexes [NiL2], [CuL2], [ZnHL(H2O)2(OAc)2], [CdHL(H

Aluminum Metal-Organic Framework-Ligated Single-Site Nickel(II)-Hydride for Heterogeneous Chemoselective Catalysis

The development of chemoselective and heterogeneous earth-abundant metal catalysts is essential for environmentally friendly chemical synthesis. We report a highly efficient, chemoselective, and reusable single-site nickel(II) hydride catalyst based on robust and porous aluminum metal-organic frameworks (MOFs) (DUT-5) for hydrogenation of nitro and nitrile compounds to the corresponding amines and hydrogenolysis of aryl ethers under mild conditions. The nickel-hydride catalyst was prepared by the metalation of aluminum hydroxide secondary building units (SBUs) of DUT-5 having the formula of Al(μ2-OH)(bpdc) (bpdc = 4,4′-biphenyldicarboxylate) with NiBr2 followed by a reaction with NaEt3BH. DUT-5-NiH has a broad substrate scope with excellent functional group tolerance in the hydrogenation of aromatic and aliphatic nitro and nitrile compounds under 1 bar H2 and could be recycled and reused at least 10 times. By changing the reaction conditions of the hydrogenation of nitriles, symmetric or unsymmetric secondary amines were also afforded selectively. The experimental and computational studies suggested reversible nitrile coordination to nickel followed by 1,2-insertion of coordinated nitrile into the nickel-hydride bond occurring in the turnover-limiting step. In addition, DUT-5-NiH is also an active catalyst for chemoselective hydrogenolysis of carbon-oxygen bonds in aryl ethers to afford hydrocarbons under atmospheric hydrogen in the absence of any base, which is important for the generation of fuels from biomass. This work highlights the potential of MOF-based single-site earth-abundant metal catalysts for practical and eco-friendly production of chemical feedstocks and biofuels.

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.

Ascorbate mediated copper catalyzed reductive cross-coupling of disulfides with aryl iodides

The concept of using ascorbic acid as a mediator/ reducing agent in a Cu(i) catalyzed process is introduced and further demonstrated on a cross-coupling reaction of aryl iodides with disulfides.

New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series

From a screening assay, 2-aminodiphenylsulfides were selected as leads for trypanothione reductase (TR) inhibition and studied by molecular modelling in the catalytic site of the enzyme. A series of analogues, monomers or bis-derivatives, were synthesized to improve binding energy and therefore inhibiting potency. These compounds appeared to be mixed competitive TR inhibitors and their inhibition profile could be explained when their aggregation in solution was taken into consideration. A bis-aminodiphenylsulfide with an IC50 of 0.55 μM was revealed to be the best TR inhibitor described so far.