19396-72-6

Basic information

• Product Name: 1-phenyloctan-2-ol
• Synonyms: Benzeneethanol, .alpha.-hexyl-
• CAS NO: 19396-72-6
• Molecular Formula: C₁₄H₂₂O
• Molecular Weight: 206.3239
• Mol File: 19396-72-6.mol

Chemical Properties

• Boiling Point: 248.8°C at 760 mmHg
• Flash Point: 108.8°C
• Density: 0.941g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 1-phenyloctan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyloctan-2-ol(19396-72-6)
• EPA Substance Registry System: 1-phenyloctan-2-ol(19396-72-6)

Safety Data

• Hazardous Substances Data: 19396-72-6(Hazardous Substances Data)

Usage

Properties

Molecular formula, C14H20O

Class

Secondary alcohol

Organic compound

1-Phenylactan-2-ol is an organic compound, which means it is primarily composed of carbon, hydrogen, and oxygen atoms.

Secondary alcohol

1-Phenylactan-2-ol is classified as a secondary alcohol, meaning the hydroxyl (OH) group is attached to a carbon atom that is bonded to two other carbon atoms.

Fragrance ingredient

This chemical is commonly used as a fragrance ingredient in various perfumes and personal care products due to its pleasant floral and fruity scent.

Popular in the cosmetic industry

The appealing aroma of 1-phenyloctan-2-ol makes it a popular choice in the cosmetic industry for use in products such as perfumes, lotions, and other scented items.

Potential pharmaceutical applications

1-Phenylactan-2-ol may have potential applications in the pharmaceutical industry, although further research is needed to determine its specific uses.

Use as a flavoring agent

The chemical may also be used as a flavoring agent in food and beverage products, given its pleasant scent and taste properties.

Flammability

1-Phenylactan-2-ol is flammable, so it is important to handle it with care and avoid exposure to open flames or high temperatures.

Health hazards

This chemical can pose potential health hazards if ingested or inhaled, so proper safety precautions should be taken when handling, using, or storing 1-phenyloctan-2-ol.

Upstream product

• 111-71-7 heptanal 
• 6921-34-2 benzylmagnesium chloride 
• 96-09-3 styrene oxide 
• 592-41-6 1-hexene 
• 111-25-1 1-bromo-hexane 
• 1151549-62-0 2,2'‐(2‐phenylethane‐1,1‐diyl)bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane) 
• 100-42-5 styrene 
• 108-86-1 bromobenzene 
• 111-66-0 oct-1-ene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 2984-50-1 1,2-Epoxyoctane 
• 98-80-6 phenylboronic acid 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 768-32-1 trimethylphenylsilane 

Downstream Products

• 6683-96-1 2-Octanone, 1-phenyl- 
• 111-71-7 heptanal 

Relevant articles and documents

Zirconium-Catalyzed Atom-Economical Synthesis of 1,1-Diborylalkanes from Terminal and Internal Alkenes

A general and atom-economical synthesis of 1,1-diborylalkanes from alkenes and a borane without the need for an additional H2 acceptor is reported for the first time. The key to our success is the use of an earth-abundant zirconium-based catalyst, which allows a balance of self-contradictory reactivities (dehydrogenative boration and hydroboration) to be achieved. Our method avoids using an excess amount of another alkene as an H2 acceptor, which was required in other reported systems. Furthermore, substrates such as simple long-chain aliphatic alkenes that did not react before also underwent 1,1-diboration in our system. Significantly, the unprecedented 1,1-diboration of internal alkenes enabled the preparation of 1,1-diborylalkanes.

Method for preparing alcohol through reaction of Suzuki no exogenous alkali (by machine translation)

The method for synthesizing the alcohol compound by. using the method disclosed by the invention for preparing .the alcohol compound by adopting the method Suzuki disclosed by the invention has the advantages that the reaction system, is convenient and convenient, to prepare, and the reaction system is convenient to prepare . Suzuki. (by machine translation)

Nickel-Catalyzed Stereoselective Arylboration of Unactivated Alkenes

A Ni-catalyzed method for arylboration is disclosed. The method allows for highly stereoselective arylboration of unactivated alkenes. The reactions utilize a simple Ni-catalyst and work with a broad range of alkenes and aryl bromides. The products represent useful intermediates for chemical synthesis due to the versatility of the C-B bond. Preliminary mechanistic details of the method are also disclosed.

Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran e and Other Targets of Interest

A hydroxyl functional group positioned β to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to control the reaction site in multiply borylated substrates and can activate boronates for reaction that would otherwise be unreactive.

Cu-Catalyzed cross-coupling reactions of epoxides with organoboron compounds

A copper-catalyzed cross-coupling reaction of epoxides with arylboronates is described. This reaction is not limited to aromatic epoxides, because aliphatic epoxides are also suitable substrates. In addition, N-sulfonyl aziridines can be successfully converted into the products. This reaction provides convenient access to β-phenethyl alcohols, which are valuable synthetic intermediates.

Nickel-catalyzed regiodivergent opening of epoxides with aryl halides: Co-catalysis controls regioselectivity

Epoxides are versatile intermediates in organic synthesis, but have rarely been employed in cross-coupling reactions. We report that bipyridine-ligated nickel can mediate the addition of functionalized aryl halides, a vinyl halide, and a vinyl triflate to epoxides under reducing conditions. For terminal epoxides, the regioselectivity of the reaction depends upon the cocatalyst employed. Iodide cocatalysis results in opening at the less hindered position via an iodohydrin intermediate. Titanocene cocatalysis results in opening at the more hindered position, presumably via TiIII-mediated radical generation. 1,2-Disubstituted epoxides are opened under both conditions to form predominantly the trans product.

A simple and inexpensive procedure for low valent copper mediated benzylation of aldehydes in wet medium

An operationally simple, inexpensive and efficient procedure for benzylation of aldehydes in wet medium has been developed that was mediated with low valent copper, prepared in situ through spontaneous reduction of CuCl 2-2H2O with magnesium in situ. Notably, copper mediated benzylation of 3h took place with good syn selectivity that was opposite to that for the corresponding Grignard addition. Finally, homobenzyl alcohol 5a was elegantly transformed into a known protease inhibitor synthon I. ARKAT USA, Inc.

Arylsilanes: Application to gold-catalyzed oxyarylation of alkenes

Arylsilanes are efficient reagents for the gold-catalyzed oxyarylation of alkenes (21 examples, up to 85% isolated yield). Using commercially available Ph3PAuCl and readily prepared, benign arylsilanes, these two- and three-component reactions

Gold-catalyzed three-component coupling: Oxidative oxyarylation of alkenes

The three-component coupling of terminal alkenes with arylboronic acids and oxygen nucleophiles is described. The reaction employs a binuclear gold(I) bromide as a catalyst and Selectfluor reagent as the stoichiometric oxidant. Alcohols, carboxylic acids, and water can be employed as oxygen nucleophiles, thus providing an efficient entry into β-aryl ethers, esters, and alcohols from alkenes.

Cadmium-mediated carbonyl benzylation in tap water

Zn/CdCl2 has been developed as a mediator in the benzylation of various aldehydes in tap water affording the corresponding alcohols in moderate to good yields. The addition of a catalytic amount of InCl3 increases the yield of benzylation product significantly. It can selectively mediate the benzylation of aldehydes in the presence of ketones. A mechanism involving the formation of a cation π-complex is proposed based on the experimental facts. Georg Thieme Verlag Stuttgart.