195136-62-0

Basic information

• Product Name: 2,4-DIMETHOXY-5-FLUORONITROBENZENE
• Synonyms: 2,4-DIMETHOXY-5-FLUORONITROBENZENE;1-Fluoro-2,4-diMethoxy-5-nitrobenzene
• CAS NO: 195136-62-0
• Molecular Formula: C₈H₈FNO₄
• Molecular Weight: 201.15
• Mol File: 195136-62-0.mol

Chemical Properties

• Melting Point: 151-153°C
• Boiling Point: 321.6 °C at 760 mmHg
• Flash Point: 148.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• CAS DataBase Reference: 2,4-DIMETHOXY-5-FLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXY-5-FLUORONITROBENZENE(195136-62-0)
• EPA Substance Registry System: 2,4-DIMETHOXY-5-FLUORONITROBENZENE(195136-62-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT, CORROSIVE
• Hazardous Substances Data: 195136-62-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-DIMETHOXY-5-FLUORONITROBENZENE is used as a key intermediate in organic synthesis for the development of a range of chemical compounds. Its unique structure allows for versatile reactions and modifications, making it a valuable component in the creation of new molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-DIMETHOXY-5-FLUORONITROBENZENE is used as a building block for the synthesis of various drugs. Its presence in the molecular structure can impart specific properties to the final product, such as increased potency or selectivity towards certain biological targets.
Used in Agrochemical Industry:
2,4-DIMETHOXY-5-FLUORONITROBENZENE is utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used in Dye Industry:
In the dye industry, 2,4-DIMETHOXY-5-FLUORONITROBENZENE is used as a precursor for the synthesis of various dyes. Its chemical properties contribute to the color and stability of the resulting dyes, making it an essential component in the production of a wide range of colorants for textiles, plastics, and other applications.

Upstream product

• 67-56-1 methanol 
• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 4920-84-7 2,4-dimethoxynitrobenzene 
• 107264-06-2 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate 
• 124-41-4 sodium methylate 

Downstream Products

• 879288-15-0 1-fluoro-5-iodo-2,4-dimethoxybenzene 
• 879288-18-3 4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid methyl ester 
• 879288-14-9 4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid 
• 952053-74-6 1-{[4-(2,7-difluoro-6-hydroxy-3-oxo-xanthen-9-yl)-3-methylbenzoyl]oxy}pyrrolidine-2,5-dione 
• 879288-21-8 N-[4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide 
• 879288-16-1 bis(5-fluoro-2,4-dimethoxyphenyl)methanone 
• 430459-44-2 5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone 
• 913689-08-4 2-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid 
• 103068-41-3 4-fluororesorcinol 
• 17715-70-7 1,3-dimethoxy-4-fluorobenzene 
• 195136-65-3 1-Amino-2,4-dimethoxy-5-fluorobenzene 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

The Pennsylvania Green fluorophore: A hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes

Fluorescent small molecules are powerful tools for exploring cellular biology. As a more hydrophobic, photostable, and less pH-sensitive alternative to fluorescein, we synthesized Pennsylvania Green, a bright, monoanionic fluorophore related to Oregon Gre

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

Fluorinated xanthene derivatives

The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

Synthesis of fluorinated fluoresceins

Several novel fluorinated fluoresceins (Oregon Green dyes) were prepared by the reaction of fluororesorcinols with phthalic anhydride and its derivatives. A novel regiospecific synthesis of fluororesorcinols was key to the successful synthesis of these new fluorophores. (Polyfluoro)- nitrobenzenes were reacted with 2 equiv of sodium methoxide followed by reduction, hydrodediazoniation, and demethylation, giving the first straightforward synthesis of 2-fluororesorcinol, 4-fluororesorcinol, 2,4- difluororesorcinol, and 2,4,5-trifluororesorcinol. These fluorinated fluoresceins have higher photostability and ionize at a lower pH (pK(a) = 3.3-6.1) than fluorescein (pK(a) = 6.5). Some of the fluorinated fluoresceins have very high quantum yields (0.85-0.97), which, in combination with their lower pK(a)s and high photostability, makes them superior fluorescent dyes for use as reporter molecules in biological systems.