1965-09-9Relevant articles and documents
Investigations into the structure-activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker
Vereshchagin, Anatoly N.,Frolov, Nikita A.,Konyuhova, Valeria Yu,Kapelistaya, Ekaterina A.,Hansford, Karl A.,Egorov, Mikhail P.
, p. 3429 - 3438 (2021)
Eighteen novel gemini quaternary ammonium compounds were synthesized to examine the effect of linker nature, aliphatic chain length and their relative position on antibacterial and antifungal activity. The synthesized compounds showed strong bacteriostatic activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and two fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics, such as benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHG) and octenidine dihydrochloride (OCT).
Aryl phenol compound as well as synthesis method and application thereof
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Paragraph 0201-0204, (2021/05/12)
The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.
Preparation method of 4, 4 '-dihydroxy diphenyl ether
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Paragraph 0007; 0015-0019, (2020/06/20)
The invention discloses a preparation method of 4, 4 '-dihydroxy diphenyl ether. The process is as follows. The preparation method comprises the following steps: reacting 4, 4 '-dibromo diphenyl etherwith an alkaline aqueous solution, dimethyl sulfoxide, a catalytic amount of an inorganic catalyst containing copper ions and a ligand compound A to generate sodium phenolate; precipitating, separating and removing the catalyst, then introducing carbon dioxide gas to replace 4, 4 '-dihydroxy diphenyl ether, and recrystallizing the 4, 4'-dihydroxy diphenyl ether crude product by using an organic solvent to obtain a 4, 4 '-dihydroxy diphenyl ether finished product with the purity of 99% or above. The invention provides a preparation method of 2, 3, 5-tetramethylpiperidine. High purity and simple process, the preparation method is low in pollution and low in production cost; according to the method, the problems of high-temperature and high-pressure hydrolysis, high energy consumption, low safety factor, low yield and the like in the prior art are solved by applying a catalytic amount of copper ion-containing inorganic catalyst and ligand, carbon dioxide is used for acidolysis, ions limited by electronic-grade products are prevented from being introduced, and meanwhile, the method is suitable for industrial production in the aspects of cost and operation.
Industrial preparation method of 4, 4 '-dibromo diphenyl ether and 4, 4'-dihydroxy diphenyl ether
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Paragraph 0059-0062, (2020/08/29)
The invention relates to an industrial preparation method of 4, 4 '-dibromo diphenyl ether and 4, 4'-dihydroxy diphenyl ether, and belongs to the technical field of organic synthesis. The method comprises the following steps: heating diphenyl ether and a catalyst in a reaction kettle to 20-100 DEG C, stirring, dropwise adding bromine, and controlling the temperature to be gradually increased alongwith the adding amount of the bromine so as to obtain a 4, 4 '-dibromo diphenyl ether crude product; absorbing hydrogen bromide gas generated in the reaction process by III grade water to prepare hydrobromic acid, wherein the reaction is carried out under a micro-negative pressure condition; recrystallizing the obtained 4, 4 '-dibromo diphenyl ether crude product by adopting an organic solvent toobtain the 4, 4'-dibromo diphenyl ether; and further adding sodium hydroxide, a catalyst and deionized water, carrying out a hydrolysis reaction, and carrying out post-treatment to prepare the 4, 4 '-dihydroxy diphenyl ether. Energy and raw material consumption can be effectively reduced, and the effects of high product efficiency, good quality and low cost are achieved. Effective environmental protection measures are taken in the production process, and a tail gas absorption device and sewage treatment facilities are arranged to effectively control and treat three wastes, so that the three wastes meet the emission standard.
Two-Dimensional Layered Zinc Silicate Nanosheets with Excellent Photocatalytic Performance for Organic Pollutant Degradation and CO2 Conversion
Wang, Lan,Bahnemann, Detlef W.,Bian, Liang,Dong, Guohui,Zhao, Jie,Wang, Chuanyi
supporting information, p. 8103 - 8108 (2019/05/22)
Two-dimensional (2D) photocatalysts are highly attractive for their great potential in environmental remediation and energy conversion. Herein, we report a novel layered zinc silicate (LZS) photocatalyst synthesized by a liquid-phase epitaxial growth route using silica derived from vermiculite, a layered silicate clay mineral, as both the lattice-matched substrate and Si source. The epitaxial growth of LZS is limited in the 2D directions, thus generating the vermiculite-type crystal structure and ultrathin nanosheet morphology with thicknesses of 8–15 nm and a lateral size of about 200 nm. Experimental observations and DFT calculations indicated that LZS has a superior band alignment for the degradation of organic pollutants and reduction of CO2 to CO. The material exhibited efficient photocatalytic performance for 4-chlorophenol (4-CP) degradation and CO2 conversion into CO and is the first example of a claylike 2D photocatalyst with strong photooxidation and photoreduction capabilities.
Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid
Assoah, Benedicta,Veiros, Luis F.,Afonso, Carlos A. M.,Candeias, Nuno R.
, p. 3856 - 3861 (2016/08/16)
A biomass-based route to the preparation of hydroquinone starting from the renewable starting material quinic acid is described. Amberlyst-15 in the dry form promoted the one-step formation of hydroquinone from quinic acid in toluene without any oxidants or metal catalysts in 72 % yield. Several acidic polymer-based resins and organic acids as promoters as well as a variety of reaction conditions were screened including temperature, concentration and low- and high-boiling-point solvents. A 1:4 (w/w) ratio of quinic acid/Amberlyst-15 was determined to be optimal to promote hydroquinone formation with only traces of a dimeric side-product. A mechanism has been proposed based on the decarbonylation of protonated quino-1,5-lactone that is supported by experimental and computational calculation data.
METHOD FOR PRODUCING PHENOLS
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Paragraph 0016; 0018; 0019; 0021; 0023, (2018/12/12)
PROBLEM TO BE SOLVED: To provide a rational and simple method which improves the yield of phenols by avoiding and suppressing the reaction of formed phenols with a diazonium salt that is an intermediate. SOLUTION: In a method for producing phenols, an aromatic amine compound is diazotized in a diluted sulfuric acid aqueous solution, then the obtained diazonium salt is supplied into a mixed aqueous solution composed of sulfuric acid and an organic compound, that is phase-separated from sulfuric acid, and the phenol formed by hydrolysis is recovered from an organic phase. COPYRIGHT: (C)2015,JPOandINPIT
Synthesis, experimental and theoretical investigation of molecular structure, IR, Raman spectra and 1H NMR analyses of 4,4′-dihydroxydiphenyl ether and 4,4′-oxybis(1-methoxybenzene)
Liu, Fu,Wei, Zhongbo,Wang, Liansheng,Wang, Zunyao
, p. 285 - 294 (2013/03/28)
4,4′-Dihydroxydiphenyl ether and 4,4′-oxybis(1-methoxybenzene) are synthesized. Experimental and theoretical studies on molecular structure, infrared spectra (IR), Raman spectra and nuclear magnetic resonance ( 1H NMR) chemical shifts of the two synthesized compounds have been worked out. All the theoretical results, which are obtained with B3LYP/6-311G(d,p) method by using the Gaussian 09 program, have been applied to simulate molecular structure, infrared, Raman and NMR spectra of the compounds. The compared results reveal that the calculated geometric parameters match well with experimental values; the scaled theoretical vibrational frequencies are in good accordance with observed spectra; and computational chemical shifts are consistent with the experimental values in most part, except for some minor deviations. These great coincidences prove that the computational method B3LYP/6-311G(d,p) can be used to predict the properties of other similar materials where it is difficult to arrive at experimental results.
MEDICAL DEVICE USING SULFONATED NEUTRALIZED POLYMERS WITH REDUCED ADHESION OF BIOLOGICAL FLUIDS
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, (2010/05/13)
A medical article having neutralized sulfonic acid groups on its surface, is disclosed. The article has reduced interaction with biological fluids such as insulin, human growth hormone and human serum albumin.
Synergy between microwave irradiation and heterogeneous catalysis in an environmentally friendly self-condensation of hydroxybenzene derivatives
Gomez, M. Victoria,Moreno, Andres,Vazquez, Ester,De La Hoz, Antonio,Aranda, Ana I.,Diaz-Ortiz, Angel
experimental part, p. 264 - 273 (2010/08/20)
Self-condensation of 1,3,5-trihydroxybenzene and 3,5-dimethoxyphenol using solid acid catalysts and microwave irradiation produces polyhydroxy-substituted biphenyl derivatives in moderate to good yields. Condensation of 1,3,5-trihydroxybenzene with p-benzoquinone gives 2,2'-dihydroxybiphenyl derivatives in good yields. On using classical heating these reactions do not occur or afford only traces of the desired products.
