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Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)(9CI) is a chemical compound characterized by the molecular formula C7H13NO2. It is an ethyl ester derivative of 2-amino-cyclopentanecarboxylic acid, existing in the cis isomer form. Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)(9CI) is notable for its potential applications in the synthesis of pharmaceuticals, agrochemicals, and organic chemistry, as well as its possible biological activities, making it a subject of interest for research and development in the pharmaceutical and medical sectors.

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  • 197916-36-2 Structure
  • Basic information

    1. Product Name: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)
    2. Synonyms: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI);Ethyl (1R,2S)-2-AMinocyclopentanecarboxylate
    3. CAS NO:197916-36-2
    4. Molecular Formula: C8H15NO2
    5. Molecular Weight: 157.2102
    6. EINECS: N/A
    7. Product Categories: CARBOXYLICESTER
    8. Mol File: 197916-36-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 213.4±33.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.045±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    8. Solubility: N/A
    9. PKA: 10.10±0.40(Predicted)
    10. CAS DataBase Reference: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)(197916-36-2)
    12. EPA Substance Registry System: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)(197916-36-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 197916-36-2(Hazardous Substances Data)

197916-36-2 Usage

Uses

Used in Pharmaceutical Synthesis:
Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)(9CI) is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the creation of new drugs, contributing to the development of novel therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, this compound serves as a precursor in the production of various agrochemicals. Its role in this sector highlights its versatility and potential to contribute to the development of effective agricultural products.
Used in Organic Chemistry Research:
Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)(9CI) is also used in the field of organic chemistry for research purposes. Its unique properties make it a valuable tool for exploring new chemical reactions and mechanisms, potentially leading to advancements in organic synthesis.
Used in Biological Research and Development:
Due to its potential biological activities, Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)(9CI) is of interest for further research and development in pharmaceutical and medical fields. Its exploration could lead to new insights into biological processes and the discovery of new therapeutic targets.

Check Digit Verification of cas no

The CAS Registry Mumber 197916-36-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,9,1 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 197916-36:
(8*1)+(7*9)+(6*7)+(5*9)+(4*1)+(3*6)+(2*3)+(1*6)=192
192 % 10 = 2
So 197916-36-2 is a valid CAS Registry Number.

197916-36-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl (1R,2S)-2-aminocyclopentanecarboxylate

1.2 Other means of identification

Product number -
Other names cis-ethyl-2-aminocyclopentane carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:197916-36-2 SDS

197916-36-2Relevant articles and documents

Expanding dynamic kinetic protocols: Transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Cuetos, Anibal,Lavandera, Ivan,Gotor, Vicente

supporting information, p. 10688 - 10690 (2013/11/06)

Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.

AMINO QUINOLINE DERIVATIVES INHIBITORS OF HCV

-

Page/Page column 67; 68, (2013/07/05)

A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents are defined herein, and methods of treating HCV infection in a patient are disclosed.

Intramolecular ester enolate-imine cyclization reactions for the asymmetric synthesis of polycyclic β-lactams and cyclic β-amino acid derivatives

Evans, Caroline D.,Mahon, Mary F.,Andrews, Philip C.,Muir, James,Bull, Steven D.

, p. 6276 - 6279 (2012/02/01)

Enolates of chiral N-(α-methyl-p-methoxybenzyl)-ω-imino-esters undergo intramolecular cyclization reactions to afford (syn)-aza-anions of β-amino esters in high dr that cyclize to afford N-(α-methyl-p- methoxybenzyl)-β-lactams that can be readily deprotec

5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS

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Page/Page column 151-152, (2008/12/06)

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

The first direct enzymatic hydrolysis of alicyclic β-amino esters: A route to enantiopure cis and trans β-amino acids

Forro, Eniko,Fueloep, Ferenc

, p. 6397 - 6401 (2008/02/13)

The first direct enzymatic method is reported for the synthesis of cis and trans βamino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic β esters in organic media. High enantioselectivities (E usually > 001) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iP iPr2O at 5°C. The resolved products, obtained in good yields (≥42%), could be easily separated.

Approach to highly enantiopure β-amino acid esters by using lipase catalysis in organic media

Kanerva, Liisa T.,Csomos, Peter,Sundholm, Oskari,Bernath, Gabor,Fueloep, Ferenc

, p. 1705 - 1716 (2007/10/03)

Ethyl esters of ten alicyclic β-aminocarboxylic acids were resolved by lipase catalysis in organic solvents. The resolution was based on acylation of the amino group at the R-stereogenic centre with various 2,2,2- trifluoroethyl esters. An increase in the hydrophobic nature of the acyl donor enhanced the enantioselectivity and reactivity in the case of lipase SP 526 from Candida antarctica, while the opposite effect was observed with lipase PS from Pseudomonas cepacia. An unexceptional enantioselectivity enhancement was observed when 2,2,2-trifluoroethyl chloroacetate was used in the case of lipase PS catalysis.

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