197916-36-2Relevant articles and documents
Expanding dynamic kinetic protocols: Transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives
Cuetos, Anibal,Lavandera, Ivan,Gotor, Vicente
supporting information, p. 10688 - 10690 (2013/11/06)
Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.
AMINO QUINOLINE DERIVATIVES INHIBITORS OF HCV
-
Page/Page column 67; 68, (2013/07/05)
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents are defined herein, and methods of treating HCV infection in a patient are disclosed.
Intramolecular ester enolate-imine cyclization reactions for the asymmetric synthesis of polycyclic β-lactams and cyclic β-amino acid derivatives
Evans, Caroline D.,Mahon, Mary F.,Andrews, Philip C.,Muir, James,Bull, Steven D.
, p. 6276 - 6279 (2012/02/01)
Enolates of chiral N-(α-methyl-p-methoxybenzyl)-ω-imino-esters undergo intramolecular cyclization reactions to afford (syn)-aza-anions of β-amino esters in high dr that cyclize to afford N-(α-methyl-p- methoxybenzyl)-β-lactams that can be readily deprotec
5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
-
Page/Page column 151-152, (2008/12/06)
The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
The first direct enzymatic hydrolysis of alicyclic β-amino esters: A route to enantiopure cis and trans β-amino acids
Forro, Eniko,Fueloep, Ferenc
, p. 6397 - 6401 (2008/02/13)
The first direct enzymatic method is reported for the synthesis of cis and trans βamino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic β esters in organic media. High enantioselectivities (E usually > 001) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iP iPr2O at 5°C. The resolved products, obtained in good yields (≥42%), could be easily separated.
Approach to highly enantiopure β-amino acid esters by using lipase catalysis in organic media
Kanerva, Liisa T.,Csomos, Peter,Sundholm, Oskari,Bernath, Gabor,Fueloep, Ferenc
, p. 1705 - 1716 (2007/10/03)
Ethyl esters of ten alicyclic β-aminocarboxylic acids were resolved by lipase catalysis in organic solvents. The resolution was based on acylation of the amino group at the R-stereogenic centre with various 2,2,2- trifluoroethyl esters. An increase in the hydrophobic nature of the acyl donor enhanced the enantioselectivity and reactivity in the case of lipase SP 526 from Candida antarctica, while the opposite effect was observed with lipase PS from Pseudomonas cepacia. An unexceptional enantioselectivity enhancement was observed when 2,2,2-trifluoroethyl chloroacetate was used in the case of lipase PS catalysis.