207395-03-7Relevant articles and documents
Diclofenac derivatives with insulin-sensitizing activity
Wang, Jian Ta,Wang, Ying,Zhang, Ji Quan,Cui, Xing,Zhang, Yi,Zhu, Gao Feng,Tang, Lei
, p. 409 - 412 (2012/01/06)
A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone.
Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac
Kenny, Jane R.,Maggs, James L.,Meng, Xiaoli,Sinnott, Deborah,Clarke, Stephen E.,Park, B. Kevin,Stachulski, Andrew V.
, p. 2816 - 2825 (2007/10/03)
In humans, metabolism of the commonly used nonsteroidal antiinflammatory drug diclofenac 1 yields principally the 4′-hydroxy 2, 5-hydroxy 3, and acyl glucuronide 4 metabolites. All three metabolites have been implicated in rare idiosyncratic adverse react