cas 207981-50-8, 2,6-DIFLUOROMANDELIC ACID | Articles data ｜lookchem

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207981-50-8

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METHOD OF PRODUCING BENZENE COMPOUND
PROBLEM TO BE SOLVED: To provide a new production method for the benzene compound represented by formula (2). SOLUTION: The present invention provides a production method for the benzene compound represented by formula (2), the method including mixing of a compound represented by formula (1) and dimethyl sulfoxide (where R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a fluorinated alkyl group, a hydroxyl group, an alkoxy group, an aryl group or a nitro group). COPYRIGHT: (C)2016,JPOandINPIT
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(2016/12/01)

Anti-viral compounds
The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.
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(2008/06/13)

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Chemical Properties

Melting Point: 142-145°C
Boiling Point: 299.258 °C at 760 mmHg
Flash Point:134.787 °C
Density: 1.523 g/cm³
Vapor Pressure: 0.000539mmHg at 25°C
Refractive Index: 1.542
PKA: 3.24±0.10(Predicted)
PSA: 57.53000
LogP: 1.08280

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