207981-50-8

Basic information

• Product Name: 2,6-DIFLUOROMANDELIC ACID
• Synonyms: 2-(2,6-difluorophenyl)-2-hydroxyacetic acid;2,6-Difluoromandelicacid90%;(2,6-Difluorophenyl)(hydroxy)acetic acid;2,6-DIFLUOROMANDELIC ACID;alpha-Hydroxy-2,6-difluorophenylacetic acid;2,6-Difluoromandelic acid, tech.;à-hydroxy-2,6-difluorophenylacetic acid;2,6-Difluoromandelicacid,tech.90%
• CAS NO: 207981-50-8
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.13
• EINECS: -0
• Product Categories: Miscellaneous
• Mol File: 207981-50-8.mol

Chemical Properties

• Melting Point: 142-145°C
• Boiling Point: 299.258 °C at 760 mmHg
• Flash Point: 134.787 °C
• Appearance: /
• Density: 1.523 g/cm³
• Vapor Pressure: 0.000539mmHg at 25°C
• Refractive Index: 1.542
• PKA: 3.24±0.10(Predicted)
• CAS DataBase Reference: 2,6-DIFLUOROMANDELIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUOROMANDELIC ACID(207981-50-8)
• EPA Substance Registry System: 2,6-DIFLUOROMANDELIC ACID(207981-50-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 207981-50-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluoromandelic Acid is used as a key intermediate in the synthesis of pharmaceuticals for its unique properties and reactivity. Its incorporation in drug development allows for the creation of novel compounds with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2,6-Difluoromandelic Acid serves as a valuable building block for the design and synthesis of new drug candidates. Its fluorinated nature and chirality contribute to the exploration of structure-activity relationships and the optimization of drug efficacy and selectivity.
Used in Drug Synthesis:
2,6-Difluoromandelic Acid is employed as a reactant in the synthesis of various drugs, particularly those targeting specific biological pathways or receptors. Its presence in the molecular structure of these drugs can influence their pharmacokinetic and pharmacodynamic properties, potentially leading to improved therapeutic outcomes.

InChI:InChI=1/C8H6F2O3/c9-4-2-1-3-5(10)6(4)7(11)8(12)13/h1-3,7,11H,(H,12,13)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 437-81-0 2,6-difluorobenzaldehyde 
• 653-37-2 perfluorobenzaldehyde 
• 60611-24-7 2-fluoro-6-(trifluoromethyl)benzaldehyde 
• 90176-80-0 2-(trifluoromethyl)-4-fluorobenzaldehyde 
• 1897-52-5 2,6 difluorobenzonitrile 

Downstream Products

• 1055904-85-2 2-(2,6-difluorophenyl)-2-methoxyacetic acid 
• 1358061-74-1 3-(2,6-difluorophenyl)-5-hydroxy-5-methyl-4-phenyl-2(5H)-furanone 
• 1358061-78-5 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-2H-pyridazine-3-one 

Relevant articles and documents

METHOD OF PRODUCING BENZENE COMPOUND

PROBLEM TO BE SOLVED: To provide a new production method for the benzene compound represented by formula (2). SOLUTION: The present invention provides a production method for the benzene compound represented by formula (2), the method including mixing of a compound represented by formula (1) and dimethyl sulfoxide (where R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a fluorinated alkyl group, a hydroxyl group, an alkoxy group, an aryl group or a nitro group). COPYRIGHT: (C)2016,JPOandINPIT

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.