22572-84-5Relevant articles and documents
A color filter and an azo compound dye for containing the same
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Paragraph 0154, (2016/10/10)
Provided is a yellow coloring matter which exhibits excellent solubility in solvents that are to be used in forming the pixels of a color filter. This azo compound is represented by formula (1) [wherein R1s are each independently a straight, branched or c
Development of triarylsulfonamides as novel anti-inflammatory agents
Greig, Iain R.,Coste, Emmanuel,Ralston, Stuart H.,Van 'T Hof, Robert J.
supporting information, p. 816 - 820 (2013/03/14)
Triaylsulfonamides were identified as novel anti-inflammatory agents, acting by inhibition of RANKL and TNFα signaling. Structure-activity studies led to the identification of compounds with in vitro potencies of 50 >50 μM). A representative compound (4k, ABD455) was able to completely prevent inflammation in vivo in a prevention model and was highly effective at controlling inflammation in a treatment model.
METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF
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Page/Page column 88, (2013/02/27)
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
Aerobic oxidation of cyclohexane using N-hydroxyphthalimide bearing fluoroalkyl chains
Guha, Samar Kumar,Obora, Yasushi,Ishihara, Daisuke,Matsubara, Hiroshi,Ryu, Ilhyong,Ishii, Yasutaka
experimental part, p. 1323 - 1330 (2009/05/30)
The N-hydroxyphthalimide derivatives, F15-and F 17-NHPI, bearing a long fluorinated alkyl chain, were prepared and their catalytic performances were compared with that of the parent compound, N-hydroxyphthalimide (NHPI). The oxidation of cyclohexane under 10 atm of air in the presence of fluorinated F15-or F17-NHPI, cobalt diacetate [Co(OAc)2], and manganese diacetate [Mn(OAc)2] without any solvent at 100°C afforded a mixture of cyclohexanol and cyclohexanone (K/A oil) as major products along with a small amount of adipic acid. It was found that F15-and F17-NHPI exhibit higher catalytic activity than NHPI for the oxidation of cyclohexane without a solvent. However, for the oxidation in acetic acid all of these catalysts afforded adipic acid as a major product in good yield and the catalytic activity of NHPI in acetic acid was almost the same as those of F15-and F 17-NHPI. The oxidation by F15-and F17-NHPI catalysts in trifluorotoluene afforded K/A oil in high selectivity with little formation of adipic acid, while NHPI was a poor catalyst under these conditions, forming K/A oil as well as adipic acid in very low yields. The oxidation in trifluorotoluene by F15-and F17-NHPI catalysts was considerably accelerated by the addition of a small amount of zirconium(IV) acetylacetonate [Zr(acac)4] to the present catalytic system to afford selectively K/A oil, but no such effect was observed in the NHPI-catalyzed oxidation in trifluorotoluene.
BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS
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Page/Page column 66, (2008/12/07)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as "BPSAAA compounds"), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
Ulbrich, Holger K.,Luxenburger, Andreas,Prech, Philip,Eriksson, Einar E.,Soehnlein, Oliver,Rotzius, Pierre,Lindbom, Lennart,Dannhardt, Gerd
, p. 5988 - 5999 (2007/10/03)
An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy LewisX is a ligand for E-, P-, and L-selectin and therefore serve
Immunoassay for phthalic acid esters
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, (2008/06/13)
The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula wherein R1and R2may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1and R2are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.
Design, Synthesis and Cytotoxicity of 2-Hydroxy-1(H)-isoindole-1,3-dione (HISD) Derivatives Against CEM/O Human Leukemia Cells in vitro
Nandy, Partha,Avramis, Vassilios I.,Lien, Eric J.
, p. 664 - 679 (2007/10/03)
2-Hydroxy-1(H)-isoindole-1,3-dione derivatives (HISDs) possess a hydroxamic acid moiety which is built into an isoindoledione ring. Seven new compounds have been synthesized and tested for cytotoxicity against CEM human leukemia cell lines. Three active c
Pyrophtalones VII. Synthese et activite anti-inflammatoire de (pyridinyl-4)-2 indanediones-1,3 substituees sur le noyau benzenique et/ou sur l'heterocycle
Leblois, Danielle,Piessard, Sylvie,Baut, Guillaume Le,Kumar, Piyush,Brion, Jean-Daniel,et al.
, p. 229 - 238 (2007/10/02)
Pyrophthalones VII.Synthesis and anti-inflammatory activity of 2-(4-pyridinyl)indane-1,3-diones diversely substituted on the benzene ring.Access routes to 2-(1,4-dihydro 4-pyridinylidene) indane-1,3-diones diversely substituted on the benzene ring are studied.The regiospecific attack of these β diketoenamines by alkyl iodides leads to N-substituted compounds.These derivatives may be obtained by any of three possible methods: (1) condensation of 4-methyl pyridine with ethyl phthalates in the absence of catalyst; (2) oxidative condensation of N-alkyl-pyridinium bromides with indane-1,3-diones; (3) aminolysis of 2-(4-4H-pyranylidene) indane-1,3-diones.Pharmacomodulation by the introduction of oxygen or sulfur containing functions (ether, thioether, alcohol, ketone, acid, ester, amide) on the nitrogen of the basic molecule is not very fruitful; only the acetic derivative 19 manifests marked antiinflammatory activity unaccompanied by anti-coagulant action.The presence of chloro, nitro or methoxyl groups on 5 after N-substitution by ethyl or piperidinylethyl groups appears to be more favorable.The most active compound 57 decreases prostaglandin production and leukocyte migration without affecting either cyclooxygenase or 5-lipoxygenase.Its interference, direct or indirect, with phospholipasic A2 activity may be envisaged in particular.Keywords - 2-(4-pyridinyl)indane-1,3-diones / heterocyclic β diketoenamines / partition coefficient / anti-inflammatory activity / mechanism of action
